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HUMAN:FRIH

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FTH1 (synonyms: FTH, FTHL6)
Protein Name(s) Ferritin heavy chain

Ferritin H subunit Cell proliferation-inducing gene 15 protein Ferritin heavy chain, N-terminally processed

External Links
UniProt P02794
EMBL X00318
M11146
M12937
X03487
X03488
M14212
M14211
M97164
L20941
AF088851
AY258285
AB062402
AK054816
DQ496108
CH471076
BC000857
BC001399
BC011359
BC013724
BC015156
BC016009
BC016857
BC063514
BC066961
BC073750
BC104643
BC105802
M15383
CCDS CCDS41655.1
PIR A23517
RefSeq NP_002023.2
UniGene Hs.524910
Hs.645560
PDB 1FHA
2CEI
2CHI
2CIH
2CLU
2CN6
2CN7
2FHA
2IU2
2Z6M
3AJO
3AJP
3AJQ
3ERZ
3ES3
4DYX
4DYY
4DYZ
4DZ0
PDBsum 1FHA
2CEI
2CHI
2CIH
2CLU
2CN6
2CN7
2FHA
2IU2
2Z6M
3AJO
3AJP
3AJQ
3ERZ
3ES3
4DYX
4DYY
4DYZ
4DZ0
ProteinModelPortal P02794
SMR P02794
BioGrid 108773
DIP DIP-38301N
IntAct P02794
MINT MINT-4822446
STRING 9606.ENSP00000273550
DrugBank DB00893
PhosphoSite P02794
DMDM 120516
UCD-2DPAGE P02794
MaxQB P02794
PaxDb P02794
PRIDE P02794
DNASU 2495
Ensembl ENST00000273550
ENST00000620041
GeneID 2495
KEGG hsa:2495
UCSC uc001nsu.3
CTD 2495
GeneCards GC11M061731
H-InvDB HIX0128677
HIX0200367
HGNC HGNC:3976
HPA CAB008623
HPA043650
MIM 134770
615517
neXtProt NX_P02794
Orphanet 247790
PharmGKB PA28392
eggNOG COG1528
GeneTree ENSGT00760000119129
HOVERGEN HBG000410
InParanoid P02794
KO K00522
OMA SASHAYM
PhylomeDB P02794
TreeFam TF313885
Reactome REACT_163699
REACT_19400
REACT_25060
ChiTaRS FTH1
EvolutionaryTrace P02794
GeneWiki FTH1
GenomeRNAi 2495
NextBio 9857
PRO PR:P02794
Proteomes UP000005640
Bgee P02794
CleanEx HS_FTH1
ExpressionAtlas P02794
Genevestigator P02794
GO GO:0005829
GO:0070062
GO:0008043
GO:0005739
GO:0005634
GO:0008199
GO:0004322
GO:0005506
GO:0006879
GO:0006955
GO:0006880
GO:0006826
GO:0061024
GO:0008285
GO:0048147
GO:0006892
GO:0055085
Gene3D 1.20.1260.10
InterPro IPR001519
IPR009040
IPR009078
IPR012347
IPR014034
IPR008331
PANTHER PTHR11431
Pfam PF00210
SUPFAM SSF47240
PROSITE PS00540
PS00204
PS50905

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

involved_in

GO:0048147

negative regulation of fibroblast proliferation

PMID:9924025[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8TD27

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8TD27

P

Seeded From UniProt

complete

involved_in

GO:0006880

intracellular sequestering of iron ion

PMID:9924025[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092
UniProtKB:P02792
WB:WBGene00001500
WB:WBGene00001501

F

Seeded From UniProt

complete

enables

GO:0008199

ferric iron binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092

F

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000153092
UniProtKB:A0A0B4KHF0
UniProtKB:A0A0B4KI27

F

Seeded From UniProt

complete

involved_in

GO:0006880

intracellular sequestering of iron ion

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092
UniProtKB:P02794
UniProtKB:P9WNE5

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000153092
RGD:61813

C

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95588
PANTHER:PTN000153092
UniProtKB:P02792

F

Seeded From UniProt

complete

enables

GO:0004322

ferroxidase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10921
PANTHER:PTN000153092
UniProtKB:P9WNE5

F

Seeded From UniProt

complete

part_of

GO:0044754

autolysosome

PMID:25327288[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006826

iron ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001519

P

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001519
InterPro:IPR008331

P

Seeded From UniProt

complete

enables

GO:0008199

ferric iron binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001519
InterPro:IPR008331

F

Seeded From UniProt

complete

enables

GO:0004322

ferroxidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.16.3.1

F

Seeded From UniProt

complete

part_of

GO:0008043

intracellular ferritin complex

PMID:6589621[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

PMID:6589621[7]
Reactome:R-HSA-917937

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

PMID:3020541[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1904813

ficolin-1-rich granule lumen

Reactome:R-HSA-6800434

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1904724

tertiary granule lumen

Reactome:R-HSA-6798745

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-434362
Reactome:R-HSA-1562626

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6800434
Reactome:R-HSA-6798745

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0409

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  4. ↑ 4.0 4.1 Wu, KJ et al. (1999) Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science 283 676-9 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page
  7. ↑ 7.0 7.1 Boyd, D et al. (1984) Isolation and characterization of a cDNA clone for human ferritin heavy chain. Proc. Natl. Acad. Sci. U.S.A. 81 4751-5 PubMed GONUTS page
  8. ↑ Hentze, MW et al. (1986) Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene. Proc. Natl. Acad. Sci. U.S.A. 83 7226-30 PubMed GONUTS page
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