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HUMAN:FA9

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) F9
Protein Name(s) Coagulation factor IX

Christmas factor Plasma thromboplastin component PTC Coagulation factor IXa light chain Coagulation factor IXa heavy chain

External Links
UniProt P00740
EMBL J00136
J00137
K02053
K02048
K02049
K02051
K02052
K02402
M11309
AL033403
AB186358
AF536327
FR846239
AK292749
CH471150
BC109214
BC109215
S68634
M35672
M19063
S66752
CCDS CCDS14666.1
PIR A00922
RefSeq NP_000124.1
UniGene Hs.522798
PDB 1CFH
1CFI
1EDM
1IXA
1MGX
1NL0
1RFN
2WPH
2WPI
2WPJ
2WPK
2WPL
2WPM
3KCG
3LC3
3LC5
PDBsum 1CFH
1CFI
1EDM
1IXA
1MGX
1NL0
1RFN
2WPH
2WPI
2WPJ
2WPK
2WPL
2WPM
3KCG
3LC3
3LC5
ProteinModelPortal P00740
SMR P00740
BioGrid 108456
DIP DIP-58520N
IntAct P00740
STRING 9606.ENSP00000218099
BindingDB P00740
ChEMBL CHEMBL2016
DrugBank DB00025
DB00170
GuidetoPHARMACOLOGY 2364
Allergome 9616
MEROPS S01.214
PhosphoSite P00740
UniCarbKB P00740
PaxDb P00740
PeptideAtlas P00740
PRIDE P00740
DNASU 2158
Ensembl ENST00000218099
ENST00000394090
GeneID 2158
KEGG hsa:2158
UCSC uc004fas.1
CTD 2158
GeneCards GC0XP138612
GeneReviews F9
HGNC HGNC:3551
MIM 300746
300807
306900
neXtProt NX_P00740
Orphanet 169799
169796
169793
177929
PharmGKB PA27954
eggNOG COG5640
GeneTree ENSGT00760000118890
HOGENOM HOG000251821
HOVERGEN HBG013304
InParanoid P00740
KO K01321
OMA SAECTVF
OrthoDB EOG75B84T
PhylomeDB P00740
TreeFam TF327329
Reactome REACT_1050
REACT_1573
REACT_1906
REACT_326
REACT_733
SABIO-RK P00740
EvolutionaryTrace P00740
GeneWiki Factor_IX
GenomeRNAi 2158
NextBio 8719
PMAP-CutDB P00740
PRO PR:P00740
Proteomes UP000005640
Bgee P00740
CleanEx HS_F9
ExpressionAtlas P00740
Genevestigator P00740
GO GO:0005788
GO:0005576
GO:0070062
GO:0005796
GO:0005886
GO:0005509
GO:0004252
GO:0007596
GO:0007598
GO:0007597
GO:0044267
GO:0017187
GO:0043687
GO:0006508
Gene3D 4.10.740.10
InterPro IPR017857
IPR000742
IPR001881
IPR013032
IPR000152
IPR018097
IPR000294
IPR012224
IPR001254
IPR018114
IPR001314
IPR009003
Pfam PF00008
PF00594
PF00089
PIRSF PIRSF001143
PRINTS PR00722
PR00001
SMART SM00181
SM00179
SM00069
SM00020
SUPFAM SSF50494
SSF57630
PROSITE PS00010
PS00022
PS01186
PS50026
PS01187
PS00011
PS50998
PS50240
PS00134
PS00135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:8632006[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001969)

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:8632006[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:9169594[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:14722079[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

PMID:2592373[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0031638

zymogen activation

PMID:2592373[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

PMID:2592373[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:2592373[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:20121197[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

PMID:20121197[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:20121197[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

PMID:20121197[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

PMID:2472424[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:14718574[9]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031638

zymogen activation

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000667592
UniProtKB:P00740
UniProtKB:P00741

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88384
PANTHER:PTN000667592
RGD:2589
UniProtKB:P00740

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000669108
RGD:3411
RGD:628678
UniProtKB:P00740

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16294
ensembl:ENSMUSP00000033477

F

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16294
ensembl:ENSMUSP00000033477

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16296
ensembl:ENSRNOP00000004559

P

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR012224
InterPro:IPR018114

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000294
InterPro:IPR001881
InterPro:IPR012224
InterPro:IPR018097
InterPro:IPR035972

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000294
InterPro:IPR035972

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012224
InterPro:IPR035694

P

Seeded From UniProt

complete

involved_in

GO:0007597

blood coagulation, intrinsic pathway

Reactome:R-HSA-140837

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006888

endoplasmic reticulum to Golgi vesicle-mediated transport

Reactome:R-HSA-159763

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-5607023
Reactome:R-HSA-158278
Reactome:R-HSA-158164

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005796

Golgi lumen

Reactome:R-HSA-159836
Reactome:R-HSA-159796

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-159836
Reactome:R-HSA-159803

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-5607023
Reactome:R-HSA-158333
Reactome:R-HSA-140823

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0007599

hemostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0356

P

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0094

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
  2. ↑ 2.0 2.1 Larson, PJ et al. (1996) Structural integrity of the gamma-carboxyglutamic acid domain of human blood coagulation factor IXa Is required for its binding to cofactor VIIIa. J. Biol. Chem. 271 3869-76 PubMed GONUTS page
  3. ↑ Wojcik, EG et al. (1997) Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa. Biochem. J. 323 ( Pt 3) 629-36 PubMed GONUTS page
  4. ↑ Huang, M et al. (2004) Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody. J. Biol. Chem. 279 14338-46 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Suehiro, K et al. (1989) Blood clotting factor IX BM Nagoya. Substitution of arginine 180 by tryptophan and its activation by alpha-chymotrypsin and rat mast cell chymase. J. Biol. Chem. 264 21257-65 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Wang, S et al. (2010) Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors. J. Med. Chem. 53 1473-82 PubMed GONUTS page
  7. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  8. ↑ Chen, SH et al. (1989) Three point mutations in the factor IX genes of five hemophilia B patients. Identification strategy using localization by altered epitopes in their hemophilic proteins. J. Clin. Invest. 84 113-8 PubMed GONUTS page
  9. ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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