HUMAN:FA9

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	F9
Protein Name(s)	Coagulation factor IX Christmas factor Plasma thromboplastin component PTC Coagulation factor IXa light chain Coagulation factor IXa heavy chain
External Links
UniProt	P00740
EMBL	J00136 J00137 K02053 K02048 K02049 K02051 K02052 K02402 M11309 AL033403 AB186358 AF536327 FR846239 AK292749 CH471150 BC109214 BC109215 S68634 M35672 M19063 S66752
CCDS	CCDS14666.1
PIR	A00922
RefSeq	NP_000124.1
UniGene	Hs.522798
PDB	1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5
PDBsum	1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5
ProteinModelPortal	P00740
SMR	P00740
BioGrid	108456
DIP	DIP-58520N
IntAct	P00740
STRING	9606.ENSP00000218099
BindingDB	P00740
ChEMBL	CHEMBL2016
DrugBank	DB00025 DB00170
GuidetoPHARMACOLOGY	2364
Allergome	9616
MEROPS	S01.214
PhosphoSite	P00740
UniCarbKB	P00740
PaxDb	P00740
PeptideAtlas	P00740
PRIDE	P00740
DNASU	2158
Ensembl	ENST00000218099 ENST00000394090
GeneID	2158
KEGG	hsa:2158
UCSC	uc004fas.1
CTD	2158
GeneCards	GC0XP138612
GeneReviews	F9
HGNC	HGNC:3551
MIM	300746 300807 306900
neXtProt	NX_P00740
Orphanet	169799 169796 169793 177929
PharmGKB	PA27954
eggNOG	COG5640
GeneTree	ENSGT00760000118890
HOGENOM	HOG000251821
HOVERGEN	HBG013304
InParanoid	P00740
KO	K01321
OMA	SAECTVF
OrthoDB	EOG75B84T
PhylomeDB	P00740
TreeFam	TF327329
Reactome	REACT_1050 REACT_1573 REACT_1906 REACT_326 REACT_733
SABIO-RK	P00740
EvolutionaryTrace	P00740
GeneWiki	Factor_IX
GenomeRNAi	2158
NextBio	8719
PMAP-CutDB	P00740
PRO	PR:P00740
Proteomes	UP000005640
Bgee	P00740
CleanEx	HS_F9
ExpressionAtlas	P00740
Genevestigator	P00740
GO	GO:0005788 GO:0005576 GO:0070062 GO:0005796 GO:0005886 GO:0005509 GO:0004252 GO:0007596 GO:0007598 GO:0007597 GO:0044267 GO:0017187 GO:0043687 GO:0006508
Gene3D	4.10.740.10
InterPro	IPR017857 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR000294 IPR012224 IPR001254 IPR018114 IPR001314 IPR009003
Pfam	PF00008 PF00594 PF00089
PIRSF	PIRSF001143
PRINTS	PR00722 PR00001
SMART	SM00181 SM00179 SM00069 SM00020
SUPFAM	SSF50494 SSF57630
PROSITE	PS00010 PS00022 PS01186 PS50026 PS01187 PS00011 PS50998 PS50240 PS00134 PS00135

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8632006^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001969)	Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:8632006^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:9169594^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:14722079^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:2592373^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031638	zymogen activation	PMID:2592373^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	PMID:2592373^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:2592373^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:20121197^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:20121197^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:20121197^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	PMID:20121197^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	PMID:2472424^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:14718574^[9]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031638	zymogen activation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000667592 UniProtKB:P00740 UniProtKB:P00741	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88384 PANTHER:PTN000667592 RGD:2589 UniProtKB:P00740	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000669108 RGD:3411 RGD:628678 UniProtKB:P00740	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16294 ensembl:ENSMUSP00000033477	F		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16294 ensembl:ENSMUSP00000033477	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16296 ensembl:ENSRNOP00000004559	P		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001254 InterPro:IPR001314 InterPro:IPR012224 InterPro:IPR018114	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000294 InterPro:IPR001881 InterPro:IPR012224 InterPro:IPR018097 InterPro:IPR035972	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000294 InterPro:IPR035972	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001254 InterPro:IPR001314 InterPro:IPR018114	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012224 InterPro:IPR035694	P		Seeded From UniProt	complete
involved_in	GO:0007597	blood coagulation, intrinsic pathway	Reactome:R-HSA-140837	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	Reactome:R-HSA-159763	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5607023 Reactome:R-HSA-158278 Reactome:R-HSA-158164	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-159836 Reactome:R-HSA-159796	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-159836 Reactome:R-HSA-159803	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-5607023 Reactome:R-HSA-158333 Reactome:R-HSA-140823	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0007599	hemostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0356	P		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0094	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ ^2.0 ^2.1 Larson, PJ et al. (1996) Structural integrity of the gamma-carboxyglutamic acid domain of human blood coagulation factor IXa Is required for its binding to cofactor VIIIa. J. Biol. Chem. 271 3869-76 PubMed GONUTS page
↑ Wojcik, EG et al. (1997) Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa. Biochem. J. 323 ( Pt 3) 629-36 PubMed GONUTS page
↑ Huang, M et al. (2004) Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody. J. Biol. Chem. 279 14338-46 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Suehiro, K et al. (1989) Blood clotting factor IX BM Nagoya. Substitution of arginine 180 by tryptophan and its activation by alpha-chymotrypsin and rat mast cell chymase. J. Biol. Chem. 264 21257-65 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Wang, S et al. (2010) Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors. J. Med. Chem. 53 1473-82 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Chen, SH et al. (1989) Three point mutations in the factor IX genes of five hemophilia B patients. Identification strategy using localization by altered epitopes in their hemophilic proteins. J. Clin. Invest. 84 113-8 PubMed GONUTS page
↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25037231-1] 1.0 ^1.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:8632006-2] 2.0 ^2.1 Larson, PJ et al. (1996) Structural integrity of the gamma-carboxyglutamic acid domain of human blood coagulation factor IXa Is required for its binding to cofactor VIIIa. J. Biol. Chem. 271 3869-76 PubMed GONUTS page

[PMID:9169594-3] Wojcik, EG et al. (1997) Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa. Biochem. J. 323 ( Pt 3) 629-36 PubMed GONUTS page

[PMID:14722079-4] Huang, M et al. (2004) Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody. J. Biol. Chem. 279 14338-46 PubMed GONUTS page

[PMID:2592373-5] 5.0 ^5.1 ^5.2 ^5.3 Suehiro, K et al. (1989) Blood clotting factor IX BM Nagoya. Substitution of arginine 180 by tryptophan and its activation by alpha-chymotrypsin and rat mast cell chymase. J. Biol. Chem. 264 21257-65 PubMed GONUTS page

[PMID:20121197-6] 6.0 ^6.1 ^6.2 ^6.3 Wang, S et al. (2010) Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors. J. Med. Chem. 53 1473-82 PubMed GONUTS page

[PMID:23533145-7] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:2472424-8] Chen, SH et al. (1989) Three point mutations in the factor IX genes of five hemophilia B patients. Identification strategy using localization by altered epitopes in their hemophilic proteins. J. Clin. Invest. 84 113-8 PubMed GONUTS page

[PMID:14718574-9] Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

HUMAN:FA9

Contents

Annotations

Notes

References

b

c

e

g

h

m

o

p

s

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools