GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:EST1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CES1 (synonyms: CES2, SES1) | |
| Protein Name(s) | Liver carboxylesterase 1
Acyl-coenzyme A:cholesterol acyltransferase ACAT Brain carboxylesterase hBr1 Carboxylesterase 1 CE-1 hCE-1 Cocaine carboxylesterase Egasyn HMSE Methylumbelliferyl-acetate deacetylase 1 Monocyte/macrophage serine esterase Retinyl ester hydrolase REH Serine esterase 1 Triacylglycerol hydrolase TGH | |
| External Links | ||
| UniProt | P23141 | |
| EMBL | M73499 L07764 L07765 D21088 S73751 AF177775 AY268104 AB119995 AB119996 AB119997 AB119998 AK290623 AK292209 AC147362 BC012418 BC110338 AB025026 M55509 X52973 M65261 | |
| CCDS | CCDS32450.1 CCDS45488.1 CCDS45489.1 | |
| PIR | A41010 | |
| RefSeq | NP_001020365.1 NP_001020366.1 NP_001257.4 | |
| UniGene | Hs.558865 | |
| PDB | 1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR 3K9B 4AB1 | |
| PDBsum | 1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR 3K9B 4AB1 | |
| ProteinModelPortal | P23141 | |
| SMR | P23141 | |
| BioGrid | 107494 | |
| IntAct | P23141 | |
| MINT | MINT-5004142 | |
| BindingDB | P23141 | |
| ChEMBL | CHEMBL2265 | |
| DrugBank | DB01086 DB01101 DB01410 DB00758 DB04838 DB06695 DB00328 DB00762 DB00583 DB00688 DB00198 DB01599 DB06201 DB00675 DB00519 | |
| GuidetoPHARMACOLOGY | 2592 | |
| MEROPS | S09.982 | |
| PhosphoSite | P23141 | |
| DMDM | 119576 | |
| MaxQB | P23141 | |
| PRIDE | P23141 | |
| DNASU | 1066 | |
| Ensembl | ENST00000360526 ENST00000361503 ENST00000422046 ENST00000571922 ENST00000574513 ENST00000576783 | |
| GeneID | 1066 | |
| KEGG | hsa:1066 | |
| UCSC | uc002eil.3 uc002eim.3 | |
| CTD | 1066 | |
| GeneCards | GC16M055836 | |
| HGNC | HGNC:1863 | |
| HPA | HPA012023 HPA046717 | |
| MIM | 114835 | |
| neXtProt | NX_P23141 | |
| PharmGKB | PA107 | |
| GeneTree | ENSGT00760000118946 | |
| HOVERGEN | HBG008839 | |
| InParanoid | P23141 | |
| KO | K01044 | |
| OMA | RENITAF | |
| OrthoDB | EOG75XGKD | |
| PhylomeDB | P23141 | |
| TreeFam | TF315470 | |
| BioCyc | MetaCyc:HS11616-MONOMER | |
| BRENDA | 3.1.1.1 | |
| SABIO-RK | P23141 | |
| ChiTaRS | CES1 | |
| EvolutionaryTrace | P23141 | |
| GeneWiki | Carboxylesterase_1 | |
| GenomeRNAi | 1066 | |
| NextBio | 4450 | |
| PRO | PR:P23141 | |
| Proteomes | UP000005640 UP000005640 | |
| Bgee | P23141 | |
| CleanEx | HS_CES1 HS_CES2 | |
| ExpressionAtlas | P23141 | |
| Genevestigator | P23141 | |
| GO | GO:0005788 GO:0052689 GO:0047374 GO:0030855 GO:0008152 GO:0009636 | |
| Gene3D | 3.40.50.1820 | |
| InterPro | IPR029058 IPR002018 IPR019826 IPR019819 | |
| Pfam | PF00135 | |
| SUPFAM | SSF53474 | |
| PROSITE | PS00122 PS00941 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016787 |
hydrolase activity |
ECO:0000314 |
F |
This paper looks at and tests the functions of liver carboxylesterase 1 which includes necessary information for the annotation |
complete | |||||
|
enables |
GO:0004771 |
sterol esterase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006695 |
cholesterol biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051791 |
medium-chain fatty acid metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030855 |
epithelial cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
results_in_acquisition_of_features_of:(CL:1000334) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000592 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2148202 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95420 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004806 |
triglyceride lipase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2148202 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004771 |
sterol esterase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2148202 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0090122 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0080030 |
methyl indole-3-acetate esterase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047374 |
methylumbelliferyl-acetate deacetylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090122 |
cholesterol ester hydrolysis involved in cholesterol transport |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009636 |
response to toxic substance |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006805 |
xenobiotic metabolic process |
Reactome:R-HSA-211945 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-9619024 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0002003 |
angiotensin maturation |
Reactome:R-HSA-2022377 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Boonyuen, U et al. (2015) Efficient in vitro refolding and functional characterization of recombinant human liver carboxylesterase (CES1) expressed in E. coli. Protein Expr. Purif. 107 68-75 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Ghosh, S (2000) Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA. Physiol. Genomics 2 1-8 PubMed GONUTS page
- ↑ Buhrke, T et al. (2011) Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Dev. Growth Differ. 53 411-26 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Kroetz, DL et al. (1993) Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms. Biochemistry 32 11606-17 PubMed GONUTS page
- ↑ Munger, JS et al. (1991) A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases. J. Biol. Chem. 266 18832-8 PubMed GONUTS page
c
e
m
p
