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HUMAN:EPHB4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) EPHB4 (synonyms: HTK, MYK1, TYRO11)
Protein Name(s) Ephrin type-B receptor 4

Hepatoma transmembrane kinase Tyrosine-protein kinase TYRO11

External Links
UniProt P54760
EMBL U07695
AF312032
EU826608
EU826609
EU826610
BC004264
BC052804
CCDS CCDS5706.1
PIR A54092
RefSeq NP_004435.3
UniGene Hs.437008
PDB 2BBA
2E7H
2HLE
2QKQ
2VWU
2VWV
2VWW
2VWX
2VWY
2VWZ
2VX0
2VX1
2X9F
2XVD
2YN8
3ZEW
4AW5
4BB4
PDBsum 2BBA
2E7H
2HLE
2QKQ
2VWU
2VWV
2VWW
2VWX
2VWY
2VWZ
2VX0
2VX1
2X9F
2XVD
2YN8
3ZEW
4AW5
4BB4
ProteinModelPortal P54760
SMR P54760
BioGrid 108364
IntAct P54760
STRING 9606.ENSP00000350896
BindingDB P54760
ChEMBL CHEMBL5147
GuidetoPHARMACOLOGY 1833
PhosphoSite P54760
DMDM 19860819
DOSAC-COBS-2DPAGE P54760
MaxQB P54760
PaxDb P54760
PRIDE P54760
DNASU 2050
Ensembl ENST00000358173
ENST00000616502
GeneID 2050
KEGG hsa:2050
UCSC uc003uwm.1
CTD 2050
GeneCards GC07M100402
H-InvDB HIX0025312
HGNC HGNC:3395
HPA CAB013537
MIM 600011
neXtProt NX_P54760
PharmGKB PA27827
eggNOG COG0515
GeneTree ENSGT00760000118975
HOGENOM HOG000233856
HOVERGEN HBG062180
InParanoid P54760
KO K05113
OMA TVFYFES
PhylomeDB P54760
TreeFam TF315608
BRENDA 2.7.10.1
Reactome REACT_228085
REACT_228170
REACT_228189
REACT_228226
SignaLink P54760
ChiTaRS EPHB4
EvolutionaryTrace P54760
GeneWiki EPH_receptor_B4
GenomeRNAi 2050
NextBio 35477787
PRO PR:P54760
Proteomes UP000005640
Bgee P54760
CleanEx HS_EPHB4
ExpressionAtlas P54760
Genevestigator P54760
GO GO:0070062
GO:0005887
GO:0005524
GO:0005003
GO:0004714
GO:0001525
GO:0007155
GO:0002042
GO:0048013
GO:0003007
GO:0018108
GO:0046777
Gene3D 1.10.150.50
2.60.120.260
2.60.40.10
InterPro IPR027936
IPR001090
IPR003961
IPR008979
IPR009030
IPR013783
IPR011009
IPR000719
IPR017441
IPR001660
IPR013761
IPR021129
IPR001245
IPR011641
IPR008266
IPR020635
IPR016257
IPR001426
Pfam PF14575
PF01404
PF00041
PF07699
PF07714
PF00536
PIRSF PIRSF000666
PRINTS PR00109
SMART SM00615
SM00060
SM00454
SM00219
SUPFAM SSF47769
SSF49265
SSF49785
SSF56112
SSF57184
PROSITE PS01186
PS51550
PS50853
PS00107
PS50011
PS00109
PS00790
PS00791
PS50105

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0005003

ephrin receptor activity

PMID:15930280[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

PMID:12734395[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

PMID:8188704[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:12734395[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0005003

ephrin receptor activity

PMID:15930280[1]

ECO:0000314

F

Figure 1

complete
CACAO 3344

part_of

GO:0005887

integral component of plasma membrane

PMID:8188704[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005003

ephrin receptor activity

PMID:12734395[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:8188704[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0003007

heart morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54761

P

Seeded From UniProt

complete

involved_in

GO:0002042

cell migration involved in sprouting angiogenesis

PMID:12734395[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54761

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015380
FB:FBgn0024245
FB:FBgn0033791
PANTHER:PTN002356460
UniProtKB:A6QR62
UniProtKB:O15146
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P11362
UniProtKB:P14616
UniProtKB:P17948
UniProtKB:P21860
UniProtKB:P35916
UniProtKB:Q01973
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q16288
UniProtKB:Q16620

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109378
PANTHER:PTN000699977

C

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104770
MGI:MGI:109378
MGI:MGI:1096337
MGI:MGI:95276
MGI:MGI:98277
MGI:MGI:99611
MGI:MGI:99654
PANTHER:PTN000699977
WB:WBGene00006868

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003366
FB:FBgn0003731
FB:FBgn0003733
FB:FBgn0283499
MGI:MGI:104757
MGI:MGI:109378
MGI:MGI:1096337
MGI:MGI:1339758
MGI:MGI:1345277
MGI:MGI:95276
MGI:MGI:95278
MGI:MGI:95294
MGI:MGI:95522
MGI:MGI:95523
MGI:MGI:95524
MGI:MGI:95525
MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96575
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:96969
MGI:MGI:97384
MGI:MGI:97530
MGI:MGI:97531
MGI:MGI:97902
MGI:MGI:98277
MGI:MGI:99216
MGI:MGI:99611
MGI:MGI:99612
MGI:MGI:99654
PANTHER:PTN002356460
RGD:2543
RGD:2611
RGD:2612
RGD:2621
RGD:2869
RGD:2917
RGD:2965
RGD:3082
RGD:3213
RGD:3214
RGD:3284
RGD:3285
RGD:620144
RGD:620714
RGD:620831
RGD:621737
RGD:69323
UniProtKB:A6QR62
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P11362
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35916
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:P54764
UniProtKB:Q02763
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q15375
UniProtKB:Q16288
UniProtKB:Q16620
UniProtKB:Q16832
UniProtKB:Q5JZY3
UniProtKB:Q91987
WB:WBGene00001184
WB:WBGene00006868
ZFIN:ZDB-GENE-020503-1
ZFIN:ZDB-GENE-020503-2
ZFIN:ZDB-GENE-060503-14
ZFIN:ZDB-GENE-070713-2
ZFIN:ZDB-GENE-980526-255
ZFIN:ZDB-GENE-980526-326
ZFIN:ZDB-GENE-990415-62

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003366
FB:FBgn0003731
FB:FBgn0003733
FB:FBgn0011829
FB:FBgn0015380
FB:FBgn0032006
FB:FBgn0283499
MGI:MGI:103581
MGI:MGI:104771
MGI:MGI:109378
MGI:MGI:98277
MGI:MGI:99611
PANTHER:PTN002356460
RGD:1560587
RGD:3213
RGD:3214
RGD:70957
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:Q02763
UniProtKB:Q16620
UniProtKB:Q9UM73
WB:WBGene00000289
WB:WBGene00000898

C

Seeded From UniProt

complete

enables

GO:0005005

transmembrane-ephrin receptor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98277
MGI:MGI:99611
PANTHER:PTN000699977
UniProtKB:P21709
UniProtKB:P54762
UniProtKB:Q5JZY3

F

Seeded From UniProt

complete

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003733
FB:FBgn0040505
FB:FBgn0283499
MGI:MGI:109378
MGI:MGI:1339758
MGI:MGI:1345277
MGI:MGI:95276
MGI:MGI:95294
MGI:MGI:95522
MGI:MGI:95524
MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:96969
MGI:MGI:97384
MGI:MGI:97530
MGI:MGI:97902
MGI:MGI:98277
MGI:MGI:99611
MGI:MGI:99612
MGI:MGI:99654
PANTHER:PTN002356460
RGD:2543
RGD:2611
RGD:2621
RGD:2869
RGD:2917
RGD:2965
RGD:3082
RGD:3213
RGD:3214
RGD:3284
RGD:3285
RGD:620144
RGD:620714
RGD:620831
RGD:621737
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07333
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P11362
UniProtKB:P14616
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35916
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q16620
UniProtKB:Q16832
UniProtKB:Q5JZY3
UniProtKB:Q91987
UniProtKB:Q9UM73
WB:WBGene00000289
WB:WBGene00006868
WB:WBGene00020504
ZFIN:ZDB-GENE-980526-255

F

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020635

F

Seeded From UniProt

complete

enables

GO:0005003

ephrin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001426
InterPro:IPR016257

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001426
InterPro:IPR016257
InterPro:IPR017441

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016257

C

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR001426
InterPro:IPR008266
InterPro:IPR016257
InterPro:IPR020635

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001426
InterPro:IPR016257

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001426

C

Seeded From UniProt

complete

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.10.1

F

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

Reactome:R-HSA-2682334

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-4093339
Reactome:R-HSA-4093336
Reactome:R-HSA-4093332
Reactome:R-HSA-4093331
Reactome:R-HSA-4093329
Reactome:R-HSA-3928657
Reactome:R-HSA-3928656
Reactome:R-HSA-3928654
Reactome:R-HSA-3928645
Reactome:R-HSA-3928641
Reactome:R-HSA-3928640
Reactome:R-HSA-3928639
Reactome:R-HSA-3928633
Reactome:R-HSA-3928631
Reactome:R-HSA-3928628
Reactome:R-HSA-3928627
Reactome:R-HSA-3928625
Reactome:R-HSA-3928624
Reactome:R-HSA-3928617
Reactome:R-HSA-3928615
Reactome:R-HSA-3928614
Reactome:R-HSA-3928612
Reactome:R-HSA-3928607
Reactome:R-HSA-3928604
Reactome:R-HSA-3928601
Reactome:R-HSA-3928598
Reactome:R-HSA-3928597
Reactome:R-HSA-3928595
Reactome:R-HSA-3928592
Reactome:R-HSA-3928591
Reactome:R-HSA-3928578

ECO:0000304

author statement supported by traceable reference used in manual assertion































C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-3928656

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-3928657

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0037

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Xia, G et al. (2005) EphB4 expression and biological significance in prostate cancer. Cancer Res. 65 4623-32 PubMed GONUTS page
  2. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Füller, T et al. (2003) Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J. Cell. Sci. 116 2461-70 PubMed GONUTS page
  4. 4.0 4.1 4.2 Bennett, BD et al. (1994) Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. J. Biol. Chem. 269 14211-8 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page