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HUMAN:EPHB4
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | EPHB4 (synonyms: HTK, MYK1, TYRO11) | |
Protein Name(s) | Ephrin type-B receptor 4
Hepatoma transmembrane kinase Tyrosine-protein kinase TYRO11 | |
External Links | ||
UniProt | P54760 | |
EMBL | U07695 AF312032 EU826608 EU826609 EU826610 BC004264 BC052804 | |
CCDS | CCDS5706.1 | |
PIR | A54092 | |
RefSeq | NP_004435.3 | |
UniGene | Hs.437008 | |
PDB | 2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4 | |
PDBsum | 2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4 | |
ProteinModelPortal | P54760 | |
SMR | P54760 | |
BioGrid | 108364 | |
IntAct | P54760 | |
STRING | 9606.ENSP00000350896 | |
BindingDB | P54760 | |
ChEMBL | CHEMBL5147 | |
GuidetoPHARMACOLOGY | 1833 | |
PhosphoSite | P54760 | |
DMDM | 19860819 | |
DOSAC-COBS-2DPAGE | P54760 | |
MaxQB | P54760 | |
PaxDb | P54760 | |
PRIDE | P54760 | |
DNASU | 2050 | |
Ensembl | ENST00000358173 ENST00000616502 | |
GeneID | 2050 | |
KEGG | hsa:2050 | |
UCSC | uc003uwm.1 | |
CTD | 2050 | |
GeneCards | GC07M100402 | |
H-InvDB | HIX0025312 | |
HGNC | HGNC:3395 | |
HPA | CAB013537 | |
MIM | 600011 | |
neXtProt | NX_P54760 | |
PharmGKB | PA27827 | |
eggNOG | COG0515 | |
GeneTree | ENSGT00760000118975 | |
HOGENOM | HOG000233856 | |
HOVERGEN | HBG062180 | |
InParanoid | P54760 | |
KO | K05113 | |
OMA | TVFYFES | |
PhylomeDB | P54760 | |
TreeFam | TF315608 | |
BRENDA | 2.7.10.1 | |
Reactome | REACT_228085 REACT_228170 REACT_228189 REACT_228226 | |
SignaLink | P54760 | |
ChiTaRS | EPHB4 | |
EvolutionaryTrace | P54760 | |
GeneWiki | EPH_receptor_B4 | |
GenomeRNAi | 2050 | |
NextBio | 35477787 | |
PRO | PR:P54760 | |
Proteomes | UP000005640 | |
Bgee | P54760 | |
CleanEx | HS_EPHB4 | |
ExpressionAtlas | P54760 | |
Genevestigator | P54760 | |
GO | GO:0070062 GO:0005887 GO:0005524 GO:0005003 GO:0004714 GO:0001525 GO:0007155 GO:0002042 GO:0048013 GO:0003007 GO:0018108 GO:0046777 | |
Gene3D | 1.10.150.50 2.60.120.260 2.60.40.10 | |
InterPro | IPR027936 IPR001090 IPR003961 IPR008979 IPR009030 IPR013783 IPR011009 IPR000719 IPR017441 IPR001660 IPR013761 IPR021129 IPR001245 IPR011641 IPR008266 IPR020635 IPR016257 IPR001426 | |
Pfam | PF14575 PF01404 PF00041 PF07699 PF07714 PF00536 | |
PIRSF | PIRSF000666 | |
PRINTS | PR00109 | |
SMART | SM00615 SM00060 SM00454 SM00219 | |
SUPFAM | SSF47769 SSF49265 SSF49785 SSF56112 SSF57184 | |
PROSITE | PS01186 PS51550 PS50853 PS00107 PS50011 PS00109 PS00790 PS00791 PS50105 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0005003 |
ephrin receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048013 |
ephrin receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046777 |
protein autophosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
GO:0005003 |
ephrin receptor activity |
ECO:0000314 |
F |
Figure 1 |
complete | |||||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005003 |
ephrin receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003007 |
heart morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002042 |
cell migration involved in sprouting angiogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0043235 |
receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015380 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0043005 |
neuron projection |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109378 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007411 |
axon guidance |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104770 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003366 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003366 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005005 |
transmembrane-ephrin receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98277 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003733 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004714 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004714 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004714 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005003 |
ephrin receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048013 |
ephrin receptor signaling pathway |
Reactome:R-HSA-2682334 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-4093339 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-3928656 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-3928657 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Xia, G et al. (2005) EphB4 expression and biological significance in prostate cancer. Cancer Res. 65 4623-32 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Füller, T et al. (2003) Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J. Cell. Sci. 116 2461-70 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Bennett, BD et al. (1994) Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. J. Biol. Chem. 269 14211-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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