HUMAN:DRD4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DRD4
Protein Name(s)	D(4) dopamine receptor D(2C) dopamine receptor Dopamine D4 receptor
External Links
UniProt	P21917
EMBL	L12398 L12397 AB065765 EU432112 AP006284 CH471158
PIR	S15079 S24195
RefSeq	NP_000788.2
UniGene	Hs.99922
ProteinModelPortal	P21917
SMR	P21917
BioGrid	108149
DIP	DIP-59865N
MINT	MINT-8090293
STRING	9606.ENSP00000176183
BindingDB	P21917
ChEMBL	CHEMBL2331075
DrugBank	DB00543 DB00714 DB01238 DB06216 DB01200 DB00248 DB00477 DB00363 DB00988 DB04946 DB01235 DB00589 DB00408 DB01403 DB00334 DB01267 DB01186 DB00413 DB00420 DB00777 DB01224 DB00409 DB00734 DB00268 DB05271 DB00246
GuidetoPHARMACOLOGY	217
PhosphoSite	P21917
DMDM	1345939
PRIDE	P21917
DNASU	1815
Ensembl	ENST00000176183
GeneID	1815
KEGG	hsa:1815
UCSC	uc001lqp.2
CTD	1815
GeneCards	GC11P000656
HGNC	HGNC:3025
MIM	126452
neXtProt	NX_P21917
PharmGKB	PA27480
GeneTree	ENSGT00770000120457
HOGENOM	HOG000239242
HOVERGEN	HBG106962
InParanoid	P21917
KO	K04147
OrthoDB	EOG769ZMG
PhylomeDB	P21917
TreeFam	TF334382
Reactome	REACT_16968 REACT_19231
ChiTaRS	DRD4
GeneWiki	Dopamine_receptor_D4
GenomeRNAi	1815
NextBio	7401
PRO	PR:P21917
Proteomes	UP000005640
Bgee	P21917
CleanEx	HS_DRD4
ExpressionAtlas	P21917
Genevestigator	P21917
GO	GO:0005938 GO:0043197 GO:0005887 GO:0016020 GO:0043025 GO:0005886 GO:0043195 GO:0012506 GO:0035240 GO:0004952 GO:0001591 GO:0008144 GO:0042802 GO:0015459 GO:0017124 GO:0000187 GO:0007195 GO:0008344 GO:0050482 GO:0001662 GO:0048148 GO:0048149 GO:0006874 GO:0007623 GO:0042417 GO:0007212 GO:0042596 GO:0007194 GO:0030818 GO:0050709 GO:1901386 GO:0008355 GO:0009648 GO:0051586 GO:2000463 GO:0033674 GO:0060406 GO:0032417 GO:0050848 GO:0042752 GO:0042053 GO:0060080 GO:0046928 GO:0001975 GO:0034776 GO:0048545 GO:0060041 GO:0007614 GO:0035176 GO:0001963
InterPro	IPR002185 IPR000929 IPR000276 IPR017452
PANTHER	PTHR24249:SF37
Pfam	PF00001
PRINTS	PR00569 PR00242 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0051379	epinephrine binding	PMID:9003072^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0051380	norepinephrine binding	PMID:9003072^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	PMID:9003072^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9003072^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	PMID:9003072^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:9003072^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	PMID:27659709^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:27659709^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:27659709^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20531939^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1901386	negative regulation of voltage-gated calcium channel activity	PMID:7921596^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060080	inhibitory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51436	P	Seeded From UniProt	complete
involved_in	GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	PMID:1840645^[5]	ECO:0000305	curator inference used in manual assertion	GO:0004952	P	Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	PMID:16839358^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050482	arachidonic acid secretion	PMID:7512953^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51436	P	Seeded From UniProt	complete
involved_in	GO:0042596	fear response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51436	P	Seeded From UniProt	complete
involved_in	GO:0042417	dopamine metabolic process	PMID:1840645^[5]	ECO:0000305	curator inference used in manual assertion	GO:0004952	P	Seeded From UniProt	complete
involved_in	GO:0042053	regulation of dopamine metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51436	P	Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	PMID:1319557^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:11409696^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:11126393^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034776	response to histamine	PMID:16839358^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033674	positive regulation of kinase activity	PMID:15755724^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032417	positive regulation of sodium:proton antiporter activity	PMID:7512953^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:9843378^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:9843378^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:7512953^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0015459	potassium channel regulator activity	PMID:12297500^[13]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51436	P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:8413587^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:1319557^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:1840645^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007212	dopamine receptor signaling pathway	PMID:1840645^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:7512953^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:7921596^[4]	ECO:0000305	curator inference used in manual assertion	GO:1901386	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:15755724^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8413587^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9843378^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	PMID:8413587^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51436	P	Seeded From UniProt	complete
involved_in	GO:0001662	behavioral fear response	PMID:12860355^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	PMID:1840645^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51436	F	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:15755724^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:9843378^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51436	P	Seeded From UniProt	complete
enables	GO:0030594	neurotransmitter receptor activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:71034	F	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2342 RGD:2343 RGD:2518 RGD:2522 RGD:2851 RGD:61800 RGD:61801 RGD:620023 RGD:62044 RGD:71034	C	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2830 RGD:2846	P	Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2851 RGD:62044	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000037 PANTHER:PTN000664111 RGD:2343 UniProtKB:P08172 UniProtKB:P08908 UniProtKB:P21917 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30546 UniProtKB:P30939 WB:WBGene00001519	C	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004168 FB:FBgn0004573 FB:FBgn0087012 FB:FBgn0263116 MGI:MGI:109323 MGI:MGI:96273 MGI:MGI:96274 MGI:MGI:96276 MGI:MGI:96281 MGI:MGI:96284 PANTHER:PTN000664111 RGD:2845 RGD:2846 RGD:2848 RGD:2850 RGD:2851 RGD:61800 RGD:62044 RGD:62388 RGD:71034 UniProtKB:A0A0B4KFU6 UniProtKB:P08908 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28223 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30939 UniProtKB:P41595 UniProtKB:P47898 UniProtKB:Q13639 WB:WBGene00004776 WB:WBGene00004779	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2518	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21320289^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21917	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21184734^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21917	F	Seeded From UniProt	complete
involved_in	GO:0098664	G protein-coupled serotonin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004993	P	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060080	C	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0060080	C	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	P	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	C	Seeded From UniProt	complete
involved_in	GO:0060080	inhibitory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	P	Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	P	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	P	Seeded From UniProt	complete
involved_in	GO:0042596	fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	P	Seeded From UniProt	complete
involved_in	GO:0042053	regulation of dopamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	P	Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	P	Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	P	Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	P	Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51436 ensembl:ENSMUSP00000026569	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002185	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002185	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	P	Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002185	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	PMID:12888781^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-390846 Reactome:R-HSA-380073	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Lanau, F et al. (1997) Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor. J. Neurochem. 68 804-12 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Zhang, X & Kim, KM (2016) Palmitoylation of the carboxyl-terminal tail of dopamine D receptor is required for surface expression, endocytosis, and signaling. Biochem. Biophys. Res. Commun. 479 398-403 PubMed GONUTS page
↑ Marley, A & von Zastrow, M (2010) DISC1 regulates primary cilia that display specific dopamine receptors. PLoS ONE 5 e10902 PubMed GONUTS page
↑ ^4.0 ^4.1 Seabrook, GR et al. (1994) Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors. Br. J. Pharmacol. 112 728-34 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Van Tol, HH et al. (1991) Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350 610-4 PubMed GONUTS page
↑ ^6.0 ^6.1 Zarei, S et al. (2006) Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors. J. Thromb. Haemost. 4 1588-95 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Chio, CL et al. (1994) D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells. J. Biol. Chem. 269 11813-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Van Tol, HH et al. (1992) Multiple dopamine D4 receptor variants in the human population. Nature 358 149-52 PubMed GONUTS page
↑ Schmidt, LA et al. (2001) Association of DRD4 with attention problems in normal childhood development. Psychiatr. Genet. 11 25-9 PubMed GONUTS page
↑ Lakatos, K et al. (2000) Dopamine D4 receptor (DRD4) gene polymorphism is associated with attachment disorganization in infants. Mol. Psychiatry 5 633-7 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Van Craenenbroeck, K et al. (2005) Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis. J. Biol. Chem. 280 19350-7 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Oldenhof, J et al. (1998) SH3 binding domains in the dopamine D4 receptor. Biochemistry 37 15726-36 PubMed GONUTS page
↑ Lavine, N et al. (2002) G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. J. Biol. Chem. 277 46010-9 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Seeman, P et al. (1993) Dopamine D4 receptors elevated in schizophrenia. Nature 365 441-5 PubMed GONUTS page
↑ Joyce, PR et al. (2003) Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders. Psychiatry Res 119 1-10 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Van Craenenbroeck, K et al. (2011) Dopamine D4 receptor oligomerization--contribution to receptor biogenesis. FEBS J. 278 1333-44 PubMed GONUTS page
↑ Borroto-Escuela, DO et al. (2011) Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions. Biochem. Biophys. Res. Commun. 404 928-34 PubMed GONUTS page
↑ Hutchison, KE et al. (2003) Olanzapine reduces craving for alcohol: a DRD4 VNTR polymorphism by pharmacotherapy interaction. Neuropsychopharmacology 28 1882-8 PubMed GONUTS page

[PMID:9003072-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Lanau, F et al. (1997) Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor. J. Neurochem. 68 804-12 PubMed GONUTS page

[PMID:27659709-2] 2.0 ^2.1 ^2.2 Zhang, X & Kim, KM (2016) Palmitoylation of the carboxyl-terminal tail of dopamine D receptor is required for surface expression, endocytosis, and signaling. Biochem. Biophys. Res. Commun. 479 398-403 PubMed GONUTS page

[PMID:20531939-3] Marley, A & von Zastrow, M (2010) DISC1 regulates primary cilia that display specific dopamine receptors. PLoS ONE 5 e10902 PubMed GONUTS page

[PMID:7921596-4] 4.0 ^4.1 Seabrook, GR et al. (1994) Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors. Br. J. Pharmacol. 112 728-34 PubMed GONUTS page

[PMID:1840645-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Van Tol, HH et al. (1991) Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350 610-4 PubMed GONUTS page

[PMID:16839358-6] 6.0 ^6.1 Zarei, S et al. (2006) Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors. J. Thromb. Haemost. 4 1588-95 PubMed GONUTS page

[PMID:7512953-7] 7.0 ^7.1 ^7.2 ^7.3 Chio, CL et al. (1994) D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells. J. Biol. Chem. 269 11813-9 PubMed GONUTS page

[PMID:1319557-8] 8.0 ^8.1 Van Tol, HH et al. (1992) Multiple dopamine D4 receptor variants in the human population. Nature 358 149-52 PubMed GONUTS page

[PMID:11409696-9] Schmidt, LA et al. (2001) Association of DRD4 with attention problems in normal childhood development. Psychiatr. Genet. 11 25-9 PubMed GONUTS page

[PMID:11126393-10] Lakatos, K et al. (2000) Dopamine D4 receptor (DRD4) gene polymorphism is associated with attachment disorganization in infants. Mol. Psychiatry 5 633-7 PubMed GONUTS page

[PMID:15755724-11] 11.0 ^11.1 ^11.2 Van Craenenbroeck, K et al. (2005) Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis. J. Biol. Chem. 280 19350-7 PubMed GONUTS page

[PMID:9843378-12] 12.0 ^12.1 ^12.2 ^12.3 Oldenhof, J et al. (1998) SH3 binding domains in the dopamine D4 receptor. Biochemistry 37 15726-36 PubMed GONUTS page

[PMID:12297500-13] Lavine, N et al. (2002) G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. J. Biol. Chem. 277 46010-9 PubMed GONUTS page

[PMID:8413587-14] 14.0 ^14.1 ^14.2 Seeman, P et al. (1993) Dopamine D4 receptors elevated in schizophrenia. Nature 365 441-5 PubMed GONUTS page

[PMID:12860355-15] Joyce, PR et al. (2003) Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders. Psychiatry Res 119 1-10 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21320289-17] Van Craenenbroeck, K et al. (2011) Dopamine D4 receptor oligomerization--contribution to receptor biogenesis. FEBS J. 278 1333-44 PubMed GONUTS page

[PMID:21184734-18] Borroto-Escuela, DO et al. (2011) Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions. Biochem. Biophys. Res. Commun. 404 928-34 PubMed GONUTS page

[PMID:12888781-19] Hutchison, KE et al. (2003) Olanzapine reduces craving for alcohol: a DRD4 VNTR polymorphism by pharmacotherapy interaction. Neuropsychopharmacology 28 1882-8 PubMed GONUTS page

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