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HUMAN:DEF3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DEFA3 (synonyms: DEF3) | |
| Protein Name(s) | Neutrophil defensin 3
Defensin, alpha 3 HNP-3 HP-3 HP3 HP 3-56 Neutrophil defensin 2 HNP-2 HP-2 HP2 | |
| External Links | ||
| UniProt | P59666 | |
| EMBL | M21131 M23281 L12691 X13621 BC027917 | |
| CCDS | CCDS5962.1 | |
| PIR | C40499 | |
| RefSeq | NP_005208.1 | |
| UniGene | Hs.654448 | |
| PDB | 1DFN 1ZMH 1ZMI 1ZMK 2PM4 2PM5 | |
| PDBsum | 1DFN 1ZMH 1ZMI 1ZMK 2PM4 2PM5 | |
| ProteinModelPortal | P59666 | |
| SMR | P59666 | |
| IntAct | P59666 | |
| MINT | MINT-1409240 | |
| STRING | 9606.ENSP00000328359 | |
| PhosphoSite | P59666 | |
| DMDM | 30316323 | |
| PaxDb | P59666 | |
| PRIDE | P59666 | |
| DNASU | 1668 | |
| Ensembl | ENST00000327857 | |
| GeneID | 1668 | |
| KEGG | hsa:1668 | |
| CTD | 1668 | |
| GeneCards | GC08M006875 | |
| HGNC | HGNC:2762 | |
| HPA | HPA052517 | |
| MIM | 604522 | |
| neXtProt | NX_P59666 | |
| PharmGKB | PA27239 | |
| eggNOG | NOG86943 | |
| HOGENOM | HOG000233351 | |
| HOVERGEN | HBG011703 | |
| InParanoid | P59666 | |
| KO | K05230 | |
| OMA | QERDDEA | |
| OrthoDB | EOG75TMFQ | |
| PhylomeDB | P59666 | |
| TreeFam | TF338414 | |
| Reactome | REACT_115574 REACT_115846 | |
| EvolutionaryTrace | P59666 | |
| GeneWiki | DEFA3 | |
| GenomeRNAi | 1668 | |
| NextBio | 6864 | |
| PMAP-CutDB | P59666 | |
| PRO | PR:P59666 | |
| Proteomes | UP000005640 | |
| Bgee | P59666 | |
| CleanEx | HS_DEFA3 | |
| ExpressionAtlas | P59666 | |
| Genevestigator | P59666 | |
| GO | GO:0035578 GO:0005576 GO:0005615 GO:0070062 GO:0005796 GO:0019731 GO:0050832 GO:0050830 GO:0051607 GO:0045087 GO:0002227 GO:0030520 GO:0031640 | |
| InterPro | IPR016327 IPR006080 IPR002366 IPR006081 | |
| PANTHER | PTHR11876 | |
| Pfam | PF00323 PF00879 | |
| PIRSF | PIRSF001875 | |
| SMART | SM00048 | |
| PROSITE | PS00269 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042742 |
defense response to bacterium |
ECO:0000314 |
P |
Table III |
complete | |||||
| GO:0050832 |
defense response to fungus |
ECO:0000314 |
P |
Table III |
complete | |||||
| GO:0051607 |
defense response to virus |
ECO:0000314 |
P |
Table III |
complete | |||||
| GO:0042581 |
ECO:0000314 |
Methods (purification of HNP) |
complete | |||||||
| GO:0001909 |
leukocyte mediated cytotoxicity |
ECO:0000314 |
P |
Table III and Methods (purification of HNP) shows HNP found in leukocytes, cytotoxicity implied from killing of target cells/virus |
complete | |||||
|
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000305 |
curator inference used in manual assertion |
GO:0031640 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050830 |
defense response to Gram-positive bacterium |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0000317) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030520 |
intracellular estrogen receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019731 |
antibacterial humoral response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0000317) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0000317) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(GO:0002371) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002227 |
innate immune response in mucosa |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(UBERON:0000317) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:94880 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061844 |
antimicrobial humoral immune response mediated by antimicrobial peptide |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002275316 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051673 |
membrane disruption in other organism |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99584 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050830 |
defense response to Gram-positive bacterium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:94880 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:94880 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019731 |
antibacterial humoral response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1915259 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1915259 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002227 |
innate immune response in mucosa |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002275316 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006952 |
defense response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR002366 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035578 |
azurophil granule lumen |
Reactome:R-HSA-1462041 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0019730 |
antimicrobial humoral response |
Reactome:R-HSA-6803157 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005796 |
Golgi lumen |
Reactome:R-HSA-1462039 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-1471354 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006952 |
defense response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031640 |
killing of cells of other organism |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042742 |
defense response to bacterium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Ganz, T et al. (1985) Defensins. Natural peptide antibiotics of human neutrophils. J. Clin. Invest. 76 1427-35 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Ericksen, B et al. (2005) Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob. Agents Chemother. 49 269-75 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Tollin, M et al. (2003) Antimicrobial peptides in the first line defence of human colon mucosa. Peptides 24 523-30 PubMed GONUTS page
- ↑ Hill, CP et al. (1991) Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science 251 1481-5 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 6.0 6.1 Escribese, MM et al. (2011) Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen. Reprod. Biol. Endocrinol. 9 118 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
a
d
- GO:0050829 ! defense response to Gram-negative bacterium
- GO:0042742 ! defense response to bacterium
- GO:0006952 ! defense response
- GO:0050830 ! defense response to Gram-positive bacterium
- GO:0051607 ! defense response to virus
- GO:0050832 ! defense response to fungus
- GO:0002371 ! dendritic cell cytokine production
- GO:0051673 ! disruption of plasma membrane integrity in another organism
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