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HUMAN:DCMC
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | MLYCD | |
Protein Name(s) | Malonyl-CoA decarboxylase, mitochondrial
MCD | |
External Links | ||
UniProt | O95822 | |
EMBL | AF097832 AF153679 AF090834 AC009119 BC000286 BC052592 | |
CCDS | CCDS42206.1 | |
RefSeq | NP_036345.2 | |
UniGene | Hs.644610 | |
PDB | 2YGW 4F0X | |
PDBsum | 2YGW 4F0X | |
ProteinModelPortal | O95822 | |
SMR | O95822 | |
BioGrid | 116989 | |
DIP | DIP-60405N | |
STRING | 9606.ENSP00000262430 | |
BindingDB | O95822 | |
ChEMBL | CHEMBL4698 | |
PhosphoSite | O95822 | |
MaxQB | O95822 | |
PaxDb | O95822 | |
PRIDE | O95822 | |
Ensembl | ENST00000262430 | |
GeneID | 23417 | |
KEGG | hsa:23417 | |
UCSC | uc002fgz.3 | |
CTD | 23417 | |
GeneCards | GC16P083932 | |
H-InvDB | HIX0173296 | |
HGNC | HGNC:7150 | |
HPA | HPA031625 | |
MIM | 248360 606761 | |
neXtProt | NX_O95822 | |
Orphanet | 943 | |
PharmGKB | PA30861 | |
eggNOG | COG1593 | |
GeneTree | ENSGT00390000005410 | |
HOGENOM | HOG000141409 | |
HOVERGEN | HBG000825 | |
InParanoid | O95822 | |
KO | K01578 | |
OMA | LDEGREQ | |
OrthoDB | EOG76X5ZZ | |
PhylomeDB | O95822 | |
TreeFam | TF312959 | |
Reactome | REACT_16957 | |
SABIO-RK | O95822 | |
UniPathway | UPA00340 | |
ChiTaRS | MLYCD | |
GenomeRNAi | 23417 | |
NextBio | 45627 | |
PRO | PR:O95822 | |
Proteomes | UP000005640 | |
Bgee | O95822 | |
CleanEx | HS_MLYCD | |
Genevestigator | O95822 | |
GO | GO:0005737 GO:0005759 GO:0005739 GO:0005782 GO:0005777 GO:0050080 GO:0005102 GO:0006085 GO:0044255 GO:0006633 GO:2001294 GO:0046321 GO:0010906 GO:0002931 GO:0044281 | |
InterPro | IPR007956 | |
Pfam | PF05292 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:2001294 |
malonyl-CoA catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001294 |
malonyl-CoA catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001294 |
malonyl-CoA catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050080 |
malonyl-CoA decarboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050080 |
malonyl-CoA decarboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050080 |
malonyl-CoA decarboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050080 |
malonyl-CoA decarboxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046321 |
positive regulation of fatty acid oxidation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(CHEBI:15756) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010906 |
regulation of glucose metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006085 |
acetyl-CoA biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006085 |
acetyl-CoA biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006085 |
acetyl-CoA biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005782 |
peroxisomal matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005777 |
peroxisome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005777 |
peroxisome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002931 |
response to ischemia |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050080 |
malonyl-CoA decarboxylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046320 |
regulation of fatty acid oxidation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031998 |
regulation of fatty acid beta-oxidation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019395 |
fatty acid oxidation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010906 |
regulation of glucose metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006085 |
acetyl-CoA biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005782 |
peroxisomal matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005777 |
peroxisome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002931 |
response to ischemia |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920F5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2001294 |
malonyl-CoA catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99J39 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0050080 |
malonyl-CoA decarboxylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99J39 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046321 |
positive regulation of fatty acid oxidation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99J39 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99J39 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99J39 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99J39 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050080 |
malonyl-CoA decarboxylase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050080 |
malonyl-CoA decarboxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050080 |
malonyl-CoA decarboxylase activity |
Reactome:R-HSA-977317 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006637 |
acyl-CoA metabolic process |
Reactome:R-HSA-977317 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006625 |
protein targeting to peroxisome |
Reactome:R-HSA-9033241 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-9033236 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005782 |
peroxisomal matrix |
Reactome:R-HSA-977317 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016831 |
carboxy-lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005777 |
peroxisome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005782 |
peroxisomal matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006085 |
acetyl-CoA biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00340 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Sacksteder, KA et al. (1999) MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency. J. Biol. Chem. 274 24461-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 FitzPatrick, DR et al. (1999) The molecular basis of malonyl-CoA decarboxylase deficiency. Am. J. Hum. Genet. 65 318-26 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Zhou, D et al. (2004) Expression, purification, and characterization of human malonyl-CoA decarboxylase. Protein Expr. Purif. 34 261-9 PubMed GONUTS page
- ↑ 4.0 4.1 Gao, J et al. (1999) Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase. J. Lipid Res. 40 178-82 PubMed GONUTS page
- ↑ 5.0 5.1 Bouzakri, K et al. (2008) Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes 57 1508-16 PubMed GONUTS page
- ↑ Ghosh, D & Berg, JM (2010) A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. J. Am. Chem. Soc. 132 3973-9 PubMed GONUTS page
- ↑ Froese, DS et al. (2013) Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure 21 1182-92 PubMed GONUTS page
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