HUMAN:DCMC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MLYCD
Protein Name(s)	Malonyl-CoA decarboxylase, mitochondrial MCD
External Links
UniProt	O95822
EMBL	AF097832 AF153679 AF090834 AC009119 BC000286 BC052592
CCDS	CCDS42206.1
RefSeq	NP_036345.2
UniGene	Hs.644610
PDB	2YGW 4F0X
PDBsum	2YGW 4F0X
ProteinModelPortal	O95822
SMR	O95822
BioGrid	116989
DIP	DIP-60405N
STRING	9606.ENSP00000262430
BindingDB	O95822
ChEMBL	CHEMBL4698
PhosphoSite	O95822
MaxQB	O95822
PaxDb	O95822
PRIDE	O95822
Ensembl	ENST00000262430
GeneID	23417
KEGG	hsa:23417
UCSC	uc002fgz.3
CTD	23417
GeneCards	GC16P083932
H-InvDB	HIX0173296
HGNC	HGNC:7150
HPA	HPA031625
MIM	248360 606761
neXtProt	NX_O95822
Orphanet	943
PharmGKB	PA30861
eggNOG	COG1593
GeneTree	ENSGT00390000005410
HOGENOM	HOG000141409
HOVERGEN	HBG000825
InParanoid	O95822
KO	K01578
OMA	LDEGREQ
OrthoDB	EOG76X5ZZ
PhylomeDB	O95822
TreeFam	TF312959
Reactome	REACT_16957
SABIO-RK	O95822
UniPathway	UPA00340
ChiTaRS	MLYCD
GenomeRNAi	23417
NextBio	45627
PRO	PR:O95822
Proteomes	UP000005640
Bgee	O95822
CleanEx	HS_MLYCD
Genevestigator	O95822
GO	GO:0005737 GO:0005759 GO:0005739 GO:0005782 GO:0005777 GO:0050080 GO:0005102 GO:0006085 GO:0044255 GO:0006633 GO:2001294 GO:0046321 GO:0010906 GO:0002931 GO:0044281
InterPro	IPR007956
Pfam	PF05292

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2001294	malonyl-CoA catabolic process	PMID:10455107^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001294	malonyl-CoA catabolic process	PMID:10417274^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001294	malonyl-CoA catabolic process	PMID:15003260^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050080	malonyl-CoA decarboxylase activity	PMID:10417274^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050080	malonyl-CoA decarboxylase activity	PMID:15003260^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050080	malonyl-CoA decarboxylase activity	PMID:10455107^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050080	malonyl-CoA decarboxylase activity	PMID:9869665^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	PMID:18314420^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(CHEBI:15756)	Seeded From UniProt	complete
involved_in	GO:0010906	regulation of glucose metabolic process	PMID:18314420^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	PMID:15003260^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006085	acetyl-CoA biosynthetic process	PMID:10417274^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006085	acetyl-CoA biosynthetic process	PMID:10455107^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006085	acetyl-CoA biosynthetic process	PMID:9869665^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005782	peroxisomal matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q920F5	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:10417274^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:10455107^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q920F5	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99J39	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:10417274^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10455107^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:20178365^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P50542	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q920F5	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23791943^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95822	F		Seeded From UniProt	complete
enables	GO:0050080	malonyl-CoA decarboxylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	F		Seeded From UniProt	complete
involved_in	GO:0046320	regulation of fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	P		Seeded From UniProt	complete
involved_in	GO:0031998	regulation of fatty acid beta-oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	P		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	P		Seeded From UniProt	complete
involved_in	GO:0010906	regulation of glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	P		Seeded From UniProt	complete
involved_in	GO:0006085	acetyl-CoA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	C		Seeded From UniProt	complete
part_of	GO:0005782	peroxisomal matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	C		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q920F5 ensembl:ENSRNOP00000019923	P		Seeded From UniProt	complete
involved_in	GO:2001294	malonyl-CoA catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J39 ensembl:ENSMUSP00000095970	P		Seeded From UniProt	complete
enables	GO:0050080	malonyl-CoA decarboxylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J39 ensembl:ENSMUSP00000095970	F		Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J39 ensembl:ENSMUSP00000095970	P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J39 ensembl:ENSMUSP00000095970	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J39 ensembl:ENSMUSP00000095970	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99J39 ensembl:ENSMUSP00000095970	C		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007956 InterPro:IPR038917	P		Seeded From UniProt	complete
enables	GO:0050080	malonyl-CoA decarboxylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007956 InterPro:IPR038917	F		Seeded From UniProt	complete
enables	GO:0050080	malonyl-CoA decarboxylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.1.1.9	F		Seeded From UniProt	complete
enables	GO:0050080	malonyl-CoA decarboxylase activity	Reactome:R-HSA-977317	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006637	acyl-CoA metabolic process	Reactome:R-HSA-977317	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006625	protein targeting to peroxisome	Reactome:R-HSA-9033241	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9033236 Reactome:R-HSA-9033235	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005782	peroxisomal matrix	Reactome:R-HSA-977317 Reactome:R-HSA-9033235	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016831	carboxy-lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0210	F		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0576 UniProtKB-SubCell:SL-0204	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C		Seeded From UniProt	complete
part_of	GO:0005782	peroxisomal matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0202	C		Seeded From UniProt	complete
involved_in	GO:0006085	acetyl-CoA biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00340	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Sacksteder, KA et al. (1999) MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency. J. Biol. Chem. 274 24461-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 FitzPatrick, DR et al. (1999) The molecular basis of malonyl-CoA decarboxylase deficiency. Am. J. Hum. Genet. 65 318-26 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Zhou, D et al. (2004) Expression, purification, and characterization of human malonyl-CoA decarboxylase. Protein Expr. Purif. 34 261-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Gao, J et al. (1999) Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase. J. Lipid Res. 40 178-82 PubMed GONUTS page
↑ ^5.0 ^5.1 Bouzakri, K et al. (2008) Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes 57 1508-16 PubMed GONUTS page
↑ Ghosh, D & Berg, JM (2010) A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. J. Am. Chem. Soc. 132 3973-9 PubMed GONUTS page
↑ Froese, DS et al. (2013) Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure 21 1182-92 PubMed GONUTS page

[PMID:10455107-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Sacksteder, KA et al. (1999) MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency. J. Biol. Chem. 274 24461-8 PubMed GONUTS page

[PMID:10417274-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 FitzPatrick, DR et al. (1999) The molecular basis of malonyl-CoA decarboxylase deficiency. Am. J. Hum. Genet. 65 318-26 PubMed GONUTS page

[PMID:15003260-3] 3.0 ^3.1 ^3.2 Zhou, D et al. (2004) Expression, purification, and characterization of human malonyl-CoA decarboxylase. Protein Expr. Purif. 34 261-9 PubMed GONUTS page

[PMID:9869665-4] 4.0 ^4.1 Gao, J et al. (1999) Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase. J. Lipid Res. 40 178-82 PubMed GONUTS page

[PMID:18314420-5] 5.0 ^5.1 Bouzakri, K et al. (2008) Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes 57 1508-16 PubMed GONUTS page

[PMID:20178365-6] Ghosh, D & Berg, JM (2010) A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. J. Am. Chem. Soc. 132 3973-9 PubMed GONUTS page

[PMID:23791943-7] Froese, DS et al. (2013) Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure 21 1182-92 PubMed GONUTS page

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HUMAN:DCMC

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