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HUMAN:DCMC

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MLYCD
Protein Name(s) Malonyl-CoA decarboxylase, mitochondrial

MCD

External Links
UniProt O95822
EMBL AF097832
AF153679
AF090834
AC009119
BC000286
BC052592
CCDS CCDS42206.1
RefSeq NP_036345.2
UniGene Hs.644610
PDB 2YGW
4F0X
PDBsum 2YGW
4F0X
ProteinModelPortal O95822
SMR O95822
BioGrid 116989
DIP DIP-60405N
STRING 9606.ENSP00000262430
BindingDB O95822
ChEMBL CHEMBL4698
PhosphoSite O95822
MaxQB O95822
PaxDb O95822
PRIDE O95822
Ensembl ENST00000262430
GeneID 23417
KEGG hsa:23417
UCSC uc002fgz.3
CTD 23417
GeneCards GC16P083932
H-InvDB HIX0173296
HGNC HGNC:7150
HPA HPA031625
MIM 248360
606761
neXtProt NX_O95822
Orphanet 943
PharmGKB PA30861
eggNOG COG1593
GeneTree ENSGT00390000005410
HOGENOM HOG000141409
HOVERGEN HBG000825
InParanoid O95822
KO K01578
OMA LDEGREQ
OrthoDB EOG76X5ZZ
PhylomeDB O95822
TreeFam TF312959
Reactome REACT_16957
SABIO-RK O95822
UniPathway UPA00340
ChiTaRS MLYCD
GenomeRNAi 23417
NextBio 45627
PRO PR:O95822
Proteomes UP000005640
Bgee O95822
CleanEx HS_MLYCD
Genevestigator O95822
GO GO:0005737
GO:0005759
GO:0005739
GO:0005782
GO:0005777
GO:0050080
GO:0005102
GO:0006085
GO:0044255
GO:0006633
GO:2001294
GO:0046321
GO:0010906
GO:0002931
GO:0044281
InterPro IPR007956
Pfam PF05292

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:2001294

malonyl-CoA catabolic process

PMID:10455107[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001294

malonyl-CoA catabolic process

PMID:10417274[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001294

malonyl-CoA catabolic process

PMID:15003260[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050080

malonyl-CoA decarboxylase activity

PMID:10417274[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050080

malonyl-CoA decarboxylase activity

PMID:15003260[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050080

malonyl-CoA decarboxylase activity

PMID:10455107[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050080

malonyl-CoA decarboxylase activity

PMID:9869665[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046321

positive regulation of fatty acid oxidation

PMID:18314420[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(CHEBI:15756)

Seeded From UniProt

complete

involved_in

GO:0010906

regulation of glucose metabolic process

PMID:18314420[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

PMID:15003260[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006085

acetyl-CoA biosynthetic process

PMID:10417274[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006085

acetyl-CoA biosynthetic process

PMID:10455107[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006085

acetyl-CoA biosynthetic process

PMID:9869665[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005782

peroxisomal matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q920F5

C

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

PMID:10417274[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

PMID:10455107[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q920F5

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99J39

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:10417274[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10455107[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:20178365[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P50542

F

Seeded From UniProt

complete

involved_in

GO:0002931

response to ischemia

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q920F5

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:23791943[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O95822

F

Seeded From UniProt

complete

enables

GO:0050080

malonyl-CoA decarboxylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

F

Seeded From UniProt

complete

involved_in

GO:0046320

regulation of fatty acid oxidation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

P

Seeded From UniProt

complete

involved_in

GO:0031998

regulation of fatty acid beta-oxidation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

P

Seeded From UniProt

complete

involved_in

GO:0019395

fatty acid oxidation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

P

Seeded From UniProt

complete

involved_in

GO:0010906

regulation of glucose metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

P

Seeded From UniProt

complete

involved_in

GO:0006085

acetyl-CoA biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

C

Seeded From UniProt

complete

part_of

GO:0005782

peroxisomal matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

C

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

C

Seeded From UniProt

complete

involved_in

GO:0002931

response to ischemia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q920F5
ensembl:ENSRNOP00000019923

P

Seeded From UniProt

complete

involved_in

GO:2001294

malonyl-CoA catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99J39
ensembl:ENSMUSP00000095970

P

Seeded From UniProt

complete

enables

GO:0050080

malonyl-CoA decarboxylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99J39
ensembl:ENSMUSP00000095970

F

Seeded From UniProt

complete

involved_in

GO:0046321

positive regulation of fatty acid oxidation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99J39
ensembl:ENSMUSP00000095970

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99J39
ensembl:ENSMUSP00000095970

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99J39
ensembl:ENSMUSP00000095970

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99J39
ensembl:ENSMUSP00000095970

C

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007956
InterPro:IPR038917

P

Seeded From UniProt

complete

enables

GO:0050080

malonyl-CoA decarboxylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007956
InterPro:IPR038917

F

Seeded From UniProt

complete

enables

GO:0050080

malonyl-CoA decarboxylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.1.1.9

F

Seeded From UniProt

complete

enables

GO:0050080

malonyl-CoA decarboxylase activity

Reactome:R-HSA-977317

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006637

acyl-CoA metabolic process

Reactome:R-HSA-977317

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006625

protein targeting to peroxisome

Reactome:R-HSA-9033241

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-9033236
Reactome:R-HSA-9033235

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005782

peroxisomal matrix

Reactome:R-HSA-977317
Reactome:R-HSA-9033235

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275

P

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016831

carboxy-lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0210

F

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0576
UniProtKB-SubCell:SL-0204

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

part_of

GO:0005782

peroxisomal matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0202

C

Seeded From UniProt

complete

involved_in

GO:0006085

acetyl-CoA biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00340

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Sacksteder, KA et al. (1999) MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency. J. Biol. Chem. 274 24461-8 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 FitzPatrick, DR et al. (1999) The molecular basis of malonyl-CoA decarboxylase deficiency. Am. J. Hum. Genet. 65 318-26 PubMed GONUTS page
  3. 3.0 3.1 3.2 Zhou, D et al. (2004) Expression, purification, and characterization of human malonyl-CoA decarboxylase. Protein Expr. Purif. 34 261-9 PubMed GONUTS page
  4. 4.0 4.1 Gao, J et al. (1999) Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase. J. Lipid Res. 40 178-82 PubMed GONUTS page
  5. 5.0 5.1 Bouzakri, K et al. (2008) Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes 57 1508-16 PubMed GONUTS page
  6. Ghosh, D & Berg, JM (2010) A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. J. Am. Chem. Soc. 132 3973-9 PubMed GONUTS page
  7. Froese, DS et al. (2013) Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure 21 1182-92 PubMed GONUTS page