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HUMAN:DCD

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DCD (synonyms: AIDD, DSEP)
Protein Name(s) Dermcidin

Preproteolysin Survival-promoting peptide DCD-1

External Links
UniProt P81605
EMBL AF144011
AY044239
AF418981
AY590150
EF503687
EF503688
EF503689
AC079310
CH471054
BC062682
BC069108
CCDS CCDS73478.1
CCDS8884.1
RefSeq NP_001287783.1
NP_444513.1
UniGene Hs.350570
PDB 2KSG
2YMK
PDBsum 2KSG
2YMK
ProteinModelPortal P81605
SMR P81605
BioGrid 125564
IntAct P81605
MINT MINT-5000551
STRING 9606.ENSP00000293371
TCDB 1.C.108.1.1
iPTMnet P81605
PhosphoSitePlus P81605
BioMuta DCD
DMDM 20141302
UCD-2DPAGE P81605
EPD P81605
PaxDb P81605
PeptideAtlas P81605
PRIDE P81605
TopDownProteomics P81605-1
DNASU 117159
Ensembl ENST00000293371
ENST00000456047
ENST00000546807
GeneID 117159
KEGG hsa:117159
UCSC uc001sgj.4
CTD 117159
DisGeNET 117159
GeneCards DCD
HGNC HGNC:14669
HPA HPA063967
MIM 606634
neXtProt NX_P81605
OpenTargets ENSG00000161634
PharmGKB PA27171
eggNOG ENOG410KF1A
ENOG411167G
GeneTree ENSGT00390000016873
HOGENOM HOG000280682
HOVERGEN HBG018946
InParanoid P81605
OMA PCHEASA
OrthoDB EOG091G0W55
PhylomeDB P81605
TreeFam TF340896
Reactome [www.reactome.org/content/detail/R-HSA-6803157 R-HSA-6803157]
EvolutionaryTrace P81605
GeneWiki Dermcidin
GenomeRNAi 117159
PMAP-CutDB P81605
PRO PR:P81605
Proteomes UP000005640
Bgee ENSG00000161634
CleanEx HS_DCD
Genevisible P81605
GO GO:0070062
GO:0031012
GO:0005576
GO:0005615
GO:0008233
GO:0003723
GO:0019730
GO:0042742
GO:0050832
GO:0031640
InterPro IPR028130
PANTHER PTHR40711:SF3
Pfam PF15291

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051873

killing by host of symbiont cells

PMID:15670776[1]

ECO:0000314

P

Human dermicidin, DCD-1, has the ability to kill cells of other organisms. The antimicrobial activity of DCD-1, in the form of purified rDCD-1L, was assessed using a microbicidal assay in vitro against five different microorganisms. rDCD-1L was show to be active against E. coli CMCC(B)44102, P. sputita, S. aureus CMCC(B)26003, and S. aureus293 with 50% of bacteria killed at the concentrations of 1.8, 0.5, 8.2, and 17.8 μg/mL, respectively (Figure 5).

complete
CACAO 12512

GO:0042742

defense response to bacterium

PMID:15670776[1]

ECO:0000314

P

The antimicrobial activity of DCD-1, in the form of purified rDCD-1L, was assessed using a microbicidal assay in vitro against five different microorganisms. rDCD-1L was show to be active against E. coli CMCC(B)44102, P. sputita, S. aureus CMCC(B)26003, and S. aureus293 with 50% of bacteria killed at the concentrations of 1.8, 0.5, 8.2, and 17.8 μg/mL, respectively (Figure 5).

complete
CACAO 12381

GO:0002376

immune system process

PMID:15670776[1]

ECO:0000314

P

Human dermicidin, DCD-1, plays a role in immune system processes. The antimicrobial immune system activity of DCD-1, in the form of purified rDCD-1L, was assessed using a microbicidal assay in vitro against five different microorganisms. rDCD-1L was show to be active against E. coli CMCC(B)44102, P. sputita, S. aureus CMCC(B)26003, and S. aureus293 with 50% of bacteria killed at the concentrations of 1.8, 0.5, 8.2, and 17.8 μg/mL, respectively (Figure 5).

complete
CACAO 12513

GO:0016045

detection of bacterium

PMID:15670776[1]

ECO:0000314

P

Human dermicidin, DCD-1, has the ability to detect bacterial cells and express antimicrobial activity against them. The antimicrobial activity of DCD-1, in the form of purified rDCD-1L, was assessed using a microbicidal assay in vitro against five different microorganisms. rDCD-1L was show to be active against E. coli CMCC(B)44102, P. sputita, S. aureus CMCC(B)26003, and S. aureus293 with 50% of bacteria killed at the concentrations of 1.8, 0.5, 8.2, and 17.8 μg/mL, respectively (Figure 5).

complete
CACAO 12514

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:9736629[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002221565
UniProtKB:P81605

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028130

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028130

F

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028130

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:14978112[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001089)

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:11694882[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:11694882[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:11694882[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:11694882[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:11694882[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

PMID:11694882[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

PMID:11694882[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

PMID:11694882[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

PMID:11694882[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:11694882[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:14978112[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001089)

Seeded From UniProt

complete

involved_in

GO:0019730

antimicrobial humoral response

Reactome:R-HSA-6803157

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6803104
Reactome:R-HSA-6803060
Reactome:R-HSA-6803047
Reactome:R-HSA-6802999

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0044

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0295

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0031640

killing of cells of other organism

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0295

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Lai, YP et al. (2005) Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide. Biochem. Biophys. Res. Commun. 328 243-50 PubMed GONUTS page
  2. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  4. ↑ Cunningham, TJ et al. (1998) Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin. J. Neurosci. 18 7047-60 PubMed GONUTS page
  5. ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 Murakami, M et al. (2004) Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. J. Immunol. 172 3070-7 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 Schittek, B et al. (2001) Dermcidin: a novel human antibiotic peptide secreted by sweat glands. Nat. Immunol. 2 1133-7 PubMed GONUTS page
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