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HUMAN:CSF3R
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CSF3R (synonyms: GCSFR) | |
| Protein Name(s) | Granulocyte colony-stimulating factor receptor
G-CSF receptor G-CSF-R | |
| External Links | ||
| UniProt | Q99062 | |
| EMBL | X55721 X55720 M59818 M59819 M59820 S71484 AY148100 BC053585 | |
| CCDS | CCDS412.1 CCDS413.1 CCDS414.1 | |
| PIR | B38252 C38252 JH0329 | |
| RefSeq | NP_000751.1 NP_724781.1 NP_758519.1 | |
| UniGene | Hs.524517 | |
| PDB | 1AZ7 2D9Q | |
| PDBsum | 1AZ7 2D9Q | |
| ProteinModelPortal | Q99062 | |
| SMR | Q99062 | |
| BioGrid | 107828 | |
| DIP | DIP-5788N | |
| IntAct | Q99062 | |
| MINT | MINT-4787360 | |
| STRING | 9606.ENSP00000342623 | |
| BindingDB | Q99062 | |
| ChEMBL | CHEMBL1996 | |
| DrugBank | DB00099 DB00019 | |
| GuidetoPHARMACOLOGY | 1719 | |
| PhosphoSite | Q99062 | |
| DMDM | 729564 | |
| PaxDb | Q99062 | |
| PRIDE | Q99062 | |
| Ensembl | ENST00000331941 ENST00000361632 ENST00000373103 ENST00000373104 ENST00000373106 | |
| GeneID | 1441 | |
| KEGG | hsa:1441 | |
| UCSC | uc001cav.2 uc001caw.2 uc001cax.2 | |
| CTD | 1441 | |
| GeneCards | GC01M036931 | |
| HGNC | HGNC:2439 | |
| HPA | CAB017116 HPA048086 | |
| MIM | 138971 162830 | |
| neXtProt | NX_Q99062 | |
| Orphanet | 98824 86829 279943 | |
| PharmGKB | PA26942 | |
| eggNOG | NOG29566 | |
| GeneTree | ENSGT00550000074436 | |
| HOGENOM | HOG000231142 | |
| HOVERGEN | HBG051130 | |
| InParanoid | Q99062 | |
| KO | K05061 | |
| OMA | YLRCDST | |
| OrthoDB | EOG7FXZXN | |
| PhylomeDB | Q99062 | |
| TreeFam | TF338122 | |
| SignaLink | Q99062 | |
| ChiTaRS | CSF3R | |
| EvolutionaryTrace | Q99062 | |
| GeneWiki | Granulocyte_colony-stimulating_factor_receptor | |
| GenomeRNAi | 1441 | |
| NextBio | 5901 | |
| PRO | PR:Q99062 | |
| Proteomes | UP000005640 | |
| Bgee | Q99062 | |
| CleanEx | HS_CSF3R | |
| ExpressionAtlas | Q99062 | |
| Genevestigator | Q99062 | |
| GO | GO:0005576 GO:0005887 GO:0004896 GO:0004872 GO:0097186 GO:0007155 GO:0006952 GO:0030593 GO:0007165 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR003961 IPR003529 IPR013783 IPR010457 | |
| Pfam | PF00041 PF06328 | |
| SMART | SM00060 | |
| SUPFAM | SSF49265 | |
| PROSITE | PS50853 PS01353 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002745476 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019978 |
interleukin-3 binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96553 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019955 |
cytokine binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104579 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104579 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004912 |
interleukin-3 receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96553 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004896 |
cytokine receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002745476 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036016 |
cellular response to interleukin-3 |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004912 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038156 |
interleukin-3-mediated signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004912 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097186 |
amelogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D4A3R0 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051916 |
granulocyte colony-stimulating factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P40223 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045637 |
regulation of myeloid cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P40223 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030593 |
neutrophil chemotaxis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P40223 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004896 |
cytokine receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006952 |
defense response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-449836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8854738 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Tweardy, DJ et al. (1992) Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34. Blood 79 1148-54 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Dong, F et al. (1995) Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N. Engl. J. Med. 333 487-93 PubMed GONUTS page
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