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HUMAN:CSF3R

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CSF3R (synonyms: GCSFR)
Protein Name(s) Granulocyte colony-stimulating factor receptor

G-CSF receptor G-CSF-R

External Links
UniProt Q99062
EMBL X55721
X55720
M59818
M59819
M59820
S71484
AY148100
BC053585
CCDS CCDS412.1
CCDS413.1
CCDS414.1
PIR B38252
C38252
JH0329
RefSeq NP_000751.1
NP_724781.1
NP_758519.1
UniGene Hs.524517
PDB 1AZ7
2D9Q
PDBsum 1AZ7
2D9Q
ProteinModelPortal Q99062
SMR Q99062
BioGrid 107828
DIP DIP-5788N
IntAct Q99062
MINT MINT-4787360
STRING 9606.ENSP00000342623
BindingDB Q99062
ChEMBL CHEMBL1996
DrugBank DB00099
DB00019
GuidetoPHARMACOLOGY 1719
PhosphoSite Q99062
DMDM 729564
PaxDb Q99062
PRIDE Q99062
Ensembl ENST00000331941
ENST00000361632
ENST00000373103
ENST00000373104
ENST00000373106
GeneID 1441
KEGG hsa:1441
UCSC uc001cav.2
uc001caw.2
uc001cax.2
CTD 1441
GeneCards GC01M036931
HGNC HGNC:2439
HPA CAB017116
HPA048086
MIM 138971
162830
neXtProt NX_Q99062
Orphanet 98824
86829
279943
PharmGKB PA26942
eggNOG NOG29566
GeneTree ENSGT00550000074436
HOGENOM HOG000231142
HOVERGEN HBG051130
InParanoid Q99062
KO K05061
OMA YLRCDST
OrthoDB EOG7FXZXN
PhylomeDB Q99062
TreeFam TF338122
SignaLink Q99062
ChiTaRS CSF3R
EvolutionaryTrace Q99062
GeneWiki Granulocyte_colony-stimulating_factor_receptor
GenomeRNAi 1441
NextBio 5901
PRO PR:Q99062
Proteomes UP000005640
Bgee Q99062
CleanEx HS_CSF3R
ExpressionAtlas Q99062
Genevestigator Q99062
GO GO:0005576
GO:0005887
GO:0004896
GO:0004872
GO:0097186
GO:0007155
GO:0006952
GO:0030593
GO:0007165
Gene3D 2.60.40.10
InterPro IPR003961
IPR003529
IPR013783
IPR010457
Pfam PF00041
PF06328
SMART SM00060
SUPFAM SSF49265
PROSITE PS50853
PS01353

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0007165

signal transduction

PMID:1371413[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002745476
UniProtKB:P10912
UniProtKB:P42702
UniProtKB:P48357
UniProtKB:Q5VWK5

C

Seeded From UniProt

complete

enables

GO:0019978

interleukin-3 binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96553
PANTHER:PTN002745575

F

Seeded From UniProt

complete

enables

GO:0019955

cytokine binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104579
MGI:MGI:1330819
MGI:MGI:2180511
PANTHER:PTN002745476
RGD:1303100
RGD:621431
UniProtKB:O75462
UniProtKB:P26992

F

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104579
MGI:MGI:1270861
MGI:MGI:1330819
MGI:MGI:1889506
MGI:MGI:2180511
MGI:MGI:96551
MGI:MGI:96560
PANTHER:PTN002745476

C

Seeded From UniProt

complete

enables

GO:0004912

interleukin-3 receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96553
PANTHER:PTN002745575

F

Seeded From UniProt

complete

enables

GO:0004896

cytokine receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002745476
UniProtKB:Q14213
UniProtKB:Q9HC73

F

Seeded From UniProt

complete

involved_in

GO:0036016

cellular response to interleukin-3

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004912

P

Seeded From UniProt

complete

involved_in

GO:0038156

interleukin-3-mediated signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004912

P

Seeded From UniProt

complete

involved_in

GO:0097186

amelogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A3R0
ensembl:ENSRNOP00000011694

P

Seeded From UniProt

complete

enables

GO:0051916

granulocyte colony-stimulating factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P40223
ensembl:ENSMUSP00000101768

F

Seeded From UniProt

complete

involved_in

GO:0045637

regulation of myeloid cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P40223
ensembl:ENSMUSP00000101768

P

Seeded From UniProt

complete

involved_in

GO:0030593

neutrophil chemotaxis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P40223
ensembl:ENSMUSP00000101768

P

Seeded From UniProt

complete

enables

GO:0004896

cytokine receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003529

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003529

C

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

PMID:7542747[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:7542747[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:7542747[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-449836

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8854738
Reactome:R-HSA-6787737

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Tweardy, DJ et al. (1992) Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34. Blood 79 1148-54 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 Dong, F et al. (1995) Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N. Engl. J. Med. 333 487-93 PubMed GONUTS page