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HUMAN:COPA1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) COL25A1 (ECO:0000312 with HGNC:HGNC:18603)
Protein Name(s) Collagen alpha-1(XXV) chain

Alzheimer disease amyloid-associated protein AMY CLAC-P Collagen-like Alzheimer amyloid plaque component CLAC

External Links
UniProt Q9BXS0
EMBL AF293340
AF293341
AC097473
AC073427
AC095066
AC004701
AC004051
CCDS CCDS43258.1
CCDS43259.1
RefSeq NP_115907.2
NP_942014.1
UniGene Hs.658842
ProteinModelPortal Q9BXS0
SMR Q9BXS0
BioGrid 124143
STRING 9606.ENSP00000329626
PhosphoSite Q9BXS0
DMDM 296434459
MaxQB Q9BXS0
PaxDb Q9BXS0
PRIDE Q9BXS0
Ensembl ENST00000399126
ENST00000399132
GeneID 84570
KEGG hsa:84570
UCSC uc003hze.2
uc003hzg.4
CTD 84570
GeneCards GC04M109731
H-InvDB HIX0004434
HGNC HGNC:18603
HPA HPA029107
MIM 610004
neXtProt NX_Q9BXS0
PharmGKB PA134912284
eggNOG NOG12793
GeneTree ENSGT00770000120541
HOGENOM HOG000085653
HOVERGEN HBG101380
InParanoid Q9BXS0
OrthoDB EOG7D59P1
PhylomeDB Q9BXS0
TreeFam TF338175
Reactome REACT_121139
REACT_150401
GeneWiki Collagen,_type_XXV,_alpha_1
GenomeRNAi 84570
NextBio 74464
PRO PR:Q9BXS0
Proteomes UP000005640
Bgee Q9BXS0
CleanEx HS_COL25A1
ExpressionAtlas Q9BXS0
Genevestigator Q9BXS0
GO GO:0005581
GO:0005788
GO:0005576
GO:0005615
GO:0016021
GO:0005887
GO:0005886
GO:0001540
GO:0008201
GO:0030574
GO:0022617
GO:0030198
InterPro IPR029575
IPR008160
PANTHER PTHR24023:SF412
Pfam PF01391

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0030020

extracellular matrix structural constituent conferring tensile strength

PMID:25037231[1]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:11927537[2]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

PMID:15522881[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:11927537[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

PMID:15615705[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

PMID:15215182[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

PMID:15522881[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

PMID:11927537[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88445
MGI:MGI:88446
MGI:MGI:88452
MGI:MGI:88453
MGI:MGI:88457
MGI:MGI:88467
PANTHER:PTN002513067

C

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1095415
MGI:MGI:2152695
MGI:MGI:2672118
MGI:MGI:88451
PANTHER:PTN002513067
WB:WBGene00001263
ZFIN:ZDB-GENE-030131-2281

P

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000707161
UniProtKB:Q9BXS0

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88452
MGI:MGI:88468
PANTHER:PTN002513067
RGD:61817
RGD:70936
RGD:727898
UniProtKB:P02452
UniProtKB:P02458
UniProtKB:P02461
UniProtKB:P08123
UniProtKB:Q9BXS0

C

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104687
MGI:MGI:2672118
MGI:MGI:88457
MGI:MGI:88467
PANTHER:PTN002513067
UniProtKB:P02461
UniProtKB:P02462
UniProtKB:P53420

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:11927537[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:11927537[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060385

axonogenesis involved in innervation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MQ5
ensembl:ENSMUSP00000079210

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-2471842
Reactome:R-HSA-2152276

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-8944250
Reactome:R-HSA-2152276
Reactome:R-HSA-2022073

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-2471842

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0005581

collagen trimer

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0176

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Hashimoto, T et al. (2002) CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. EMBO J. 21 1524-34 PubMed GONUTS page
  3. ↑ 3.0 3.1 Söderberg, L et al. (2005) Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site. J. Biol. Chem. 280 1007-15 PubMed GONUTS page
  4. ↑ Osada, Y et al. (2005) CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. J. Biol. Chem. 280 8596-605 PubMed GONUTS page
  5. ↑ Kowa, H et al. (2004) Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. Am. J. Pathol. 165 273-81 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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