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HUMAN:CLC4M
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CLEC4M (synonyms: CD209L, CD209L1, CD299) | |
| Protein Name(s) | C-type lectin domain family 4 member M
CD209 antigen-like protein 1 DC-SIGN-related protein DC-SIGNR Dendritic cell-specific ICAM-3-grabbing non-integrin 2 DC-SIGN2 Liver/lymph node-specific ICAM-3-grabbing non-integrin L-SIGN | |
| External Links | ||
| UniProt | Q9H2X3 | |
| EMBL | AB015629 AF245219 AF209481 AF209480 AY042234 AY042235 AY042236 AY042237 AY042238 AY042239 AY042240 AF290887 AY343913 AK023750 AK292278 AC008812 BC038851 | |
| CCDS | CCDS12187.1 CCDS59346.1 CCDS59347.1 CCDS59348.1 | |
| RefSeq | NP_001138377.1 NP_001138378.1 NP_001138379.1 NP_001138380.1 NP_001138381.1 NP_001138382.1 NP_001138383.1 NP_055072.3 XP_006722678.1 | |
| UniGene | Hs.421437 | |
| PDB | 1K9J 1SL6 1XAR 1XPH 1Z0Y 3JQH | |
| PDBsum | 1K9J 1SL6 1XAR 1XPH 1Z0Y 3JQH | |
| ProteinModelPortal | Q9H2X3 | |
| SMR | Q9H2X3 | |
| BioGrid | 115615 | |
| IntAct | Q9H2X3 | |
| MINT | MINT-1489134 | |
| ChEMBL | CHEMBL2176858 | |
| PhosphoSite | Q9H2X3 | |
| DMDM | 46395990 | |
| PaxDb | Q9H2X3 | |
| PRIDE | Q9H2X3 | |
| DNASU | 10332 | |
| Ensembl | ENST00000248228 ENST00000327325 ENST00000359059 ENST00000595496 ENST00000596363 ENST00000597522 | |
| GeneID | 10332 | |
| KEGG | hsa:10332 | |
| UCSC | uc002mhy.2 uc002mhz.3 uc002mia.3 uc002mic.3 uc002mih.3 uc010xjw.2 | |
| CTD | 10332 | |
| GeneCards | GC19P007828 | |
| HGNC | HGNC:13523 | |
| HPA | CAB033689 CAB033691 HPA042661 | |
| MIM | 605872 | |
| neXtProt | NX_Q9H2X3 | |
| PharmGKB | PA26200 | |
| eggNOG | NOG314197 | |
| GeneTree | ENSGT00760000118924 | |
| HOVERGEN | HBG050992 | |
| InParanoid | Q9H2X3 | |
| KO | K06563 | |
| OMA | DNYWICK | |
| OrthoDB | EOG7DFXC9 | |
| PhylomeDB | Q9H2X3 | |
| TreeFam | TF333341 | |
| EvolutionaryTrace | Q9H2X3 | |
| GeneWiki | CLEC4M | |
| GenomeRNAi | 10332 | |
| NextBio | 39173 | |
| PRO | PR:Q9H2X3 | |
| Proteomes | UP000005640 | |
| Bgee | Q9H2X3 | |
| ExpressionAtlas | Q9H2X3 | |
| Genevestigator | Q9H2X3 | |
| GO | GO:0005737 GO:0005576 GO:0005887 GO:0016020 GO:0030246 GO:0030369 GO:0005537 GO:0046872 GO:0042605 GO:0004872 GO:0046790 GO:0019882 GO:0009988 GO:0006897 GO:0045087 GO:0035556 GO:0075733 GO:0007159 GO:0019048 GO:0046968 GO:0030193 GO:0010468 GO:0019079 GO:0019062 | |
| Gene3D | 3.10.100.10 | |
| InterPro | IPR001304 IPR016186 IPR018378 IPR016187 | |
| Pfam | PF00059 | |
| SMART | SM00034 | |
| SUPFAM | SSF56436 | |
| PROSITE | PS00615 PS50041 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0001618 |
viral receptor activity |
ECO:0000315 |
F |
Fig. 2A |
complete | |||||
| GO:0001618 |
viral receptor activity |
ECO:0000314 |
F |
Fig. 4 |
complete | |||||
|
enables |
GO:0001618 |
virus receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001618 |
virus receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:Q03463:PRO_0000278734 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046968 |
peptide antigen transport |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042605 |
peptide antigen binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030369 |
ICAM-3 receptor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019882 |
antigen processing and presentation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019079 |
viral genome replication |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007159 |
leukocyte cell-cell adhesion |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043657 |
host cell |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0075733 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0001618 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0001618 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0001618 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075733 |
intracellular transport of virus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046790 |
virion binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019062 |
virion attachment to host cell |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019048 |
modulation by virus of host morphology or physiology |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009988 |
cell-cell recognition |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001618 |
virus receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005537 |
mannose binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002250 |
adaptive immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Jeffers, SA et al. (2004) CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc. Natl. Acad. Sci. U.S.A. 101 15748-53 PubMed GONUTS page
- ↑ Lozach, PY et al. (2003) DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2. J. Biol. Chem. 278 20358-66 PubMed GONUTS page
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 Mummidi, S et al. (2001) Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts. J. Biol. Chem. 276 33196-212 PubMed GONUTS page
- ↑ 4.0 4.1 Bashirova, AA et al. (2001) A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J. Exp. Med. 193 671-8 PubMed GONUTS page
- ↑ Yokoyama-Kobayashi, M et al. (1999) Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. Gene 228 161-7 PubMed GONUTS page
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