HUMAN:CFAH

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CFH (synonyms: HF, HF1, HF2)
Protein Name(s)	Complement factor H H factor 1
External Links
UniProt	P08603
EMBL	Y00716 DQ233256 AL049744 BC037285 BC110643 BC142699 X04697 X07523 M12383 M65294 U56979 Z29665
CCDS	CCDS1385.1 CCDS53452.1
PIR	S00254 S03013
RefSeq	NP_000177.2
UniGene	Hs.363396
PDB	1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38 4K12 4ONT
PDBsum	1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38 4K12 4ONT
ProteinModelPortal	P08603
SMR	P08603
BioGrid	109324
DIP	DIP-38303N
IntAct	P08603
STRING	9606.ENSP00000356399
BindingDB	P08603
ChEMBL	CHEMBL4629
PhosphoSite	P08603
BioMuta	CFH
DMDM	158517847
MaxQB	P08603
PaxDb	P08603
PRIDE	P08603
DNASU	3075
Ensembl	ENST00000367429
GeneID	3075
KEGG	hsa:3075
UCSC	uc001gtj.4
CTD	3075
GeneCards	GC01P196621
GeneReviews	CFH
HGNC	HGNC:4883
HPA	CAB016385 CAB016769 HPA038922 HPA049176 HPA053326
MIM	126700 134370 235400 609814 610698
neXtProt	NX_P08603
Orphanet	279 93579 244275 93571 75376 244242 200421 329903
PharmGKB	PA29261
eggNOG	NOG148800
HOVERGEN	HBG005665
InParanoid	P08603
KO	K04004
OrthoDB	EOG75XGK1
PhylomeDB	P08603
TreeFam	TF326157
Reactome	REACT_118707
ChiTaRS	CFH
EvolutionaryTrace	P08603
GeneWiki	Factor_H
GenomeRNAi	3075
NextBio	12163
PRO	PR:P08603
Proteomes	UP000005640
Bgee	P08603
ExpressionAtlas	P08603
Genevisible	P08603
GO	GO:0072562 GO:0070062 GO:0005576 GO:0005615 GO:0043395 GO:0008201 GO:0006956 GO:0006957 GO:0045087 GO:0030449
InterPro	IPR000436
Pfam	PF00084
SMART	SM00032
SUPFAM	SSF57535
PROSITE	PS50923

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005615	extracellular space		ECO:0000304			C	Source: ProtInc	Missing: reference
involved_in	GO:0006956	complement activation	PMID:24835392^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:22471560^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:22471560^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1903659	regulation of complement-dependent cytotoxicity	PMID:25284781^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030449	regulation of complement activation	PMID:25284781^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006956	complement activation	PMID:9312129^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9312129^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030449	regulation of complement activation	Reactome:R-HSA-977606	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-981728 Reactome:R-HSA-977605 Reactome:R-HSA-977371 Reactome:R-HSA-977363 Reactome:R-HSA-977359 Reactome:R-HSA-976810 Reactome:R-HSA-976768 Reactome:R-HSA-976743 Reactome:R-HSA-1006169	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
involved_in	GO:0006957	complement activation, alternative pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0179	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Fleury, C et al. (2014) Identification of a Haemophilus influenzae factor H-Binding lipoprotein involved in serum resistance. J. Immunol. 192 5913-23 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ ^4.0 ^4.1 Khan, S et al. (2012) Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin. Biochem. J. 444 417-28 PubMed GONUTS page
↑ ^5.0 ^5.1 Maehara, N et al. (2014) Circulating AIM prevents hepatocellular carcinoma through complement activation. Cell Rep 9 61-74 PubMed GONUTS page
↑ ^6.0 ^6.1 Ault, BH et al. (1997) Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism. J. Biol. Chem. 272 25168-75 PubMed GONUTS page

[PMID:24835392-1] Fleury, C et al. (2014) Identification of a Haemophilus influenzae factor H-Binding lipoprotein involved in serum resistance. J. Immunol. 192 5913-23 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:22516433-3] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:22471560-4] 4.0 ^4.1 Khan, S et al. (2012) Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin. Biochem. J. 444 417-28 PubMed GONUTS page

[PMID:25284781-5] 5.0 ^5.1 Maehara, N et al. (2014) Circulating AIM prevents hepatocellular carcinoma through complement activation. Cell Rep 9 61-74 PubMed GONUTS page

[PMID:9312129-6] 6.0 ^6.1 Ault, BH et al. (1997) Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism. J. Biol. Chem. 272 25168-75 PubMed GONUTS page

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HUMAN:CFAH

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