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HUMAN:CFAB

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CFB (synonyms: BF, BFD)
Protein Name(s) Complement factor B

C3/C5 convertase Glycine-rich beta glycoprotein GBG PBF2 Properdin factor B Complement factor B Ba fragment Complement factor B Bb fragment

External Links
UniProt P00751
EMBL X72875
S67310
L15702
X00284
AF349679
AF019413
AF551848
AL844853
AL662849
BX005143
CR759782
CR388219
AK223400
AL645922
CH471081
BC004143
BC007990
K01566
J00125
J00126
J00185
J00186
M15082
CCDS CCDS4729.1
PIR S34075
RefSeq NP_001701.2
UniGene Hs.69771
PDB 1DLE
1Q0P
1RRK
1RS0
1RTK
2OK5
2WIN
2XWB
2XWJ
3HRZ
3HS0
PDBsum 1DLE
1Q0P
1RRK
1RS0
1RTK
2OK5
2WIN
2XWB
2XWJ
3HRZ
3HS0
ProteinModelPortal P00751
SMR P00751
BioGrid 107098
DIP DIP-38319N
IntAct P00751
MINT MINT-3003542
STRING 9606.ENSP00000416561
BindingDB P00751
ChEMBL CHEMBL5731
MEROPS S01.196
PhosphoSite P00751
BioMuta CFB
DMDM 584908
DOSAC-COBS-2DPAGE P00751
REPRODUCTION-2DPAGE P00751
SWISS-2DPAGE P00751
MaxQB P00751
PaxDb P00751
PeptideAtlas P00751
PRIDE P00751
DNASU 629
Ensembl ENST00000399981
ENST00000417261
ENST00000419411
ENST00000419920
ENST00000424727
ENST00000425368
ENST00000426239
ENST00000427888
ENST00000433503
ENST00000436692
ENST00000455591
GeneID 629
KEGG hsa:629
UCSC uc003nyi.2
uc003nyj.4
CTD 629
GeneCards GC06P031931
GC06Pj31900
GC06Pk31895
GC06Pm31989
GC06Pn31885
GC06Po31905
GeneReviews CFB
H-InvDB HIX0038706
HGNC HGNC:1037
HPA CAB016381
HPA001817
HPA001832
MIM 138470
603075
612924
615561
neXtProt NX_P00751
Orphanet 279
93578
PharmGKB PA25341
eggNOG NOG304026
GeneTree ENSGT00530000063826
HOVERGEN HBG002567
InParanoid P00751
KO K01335
OMA MENLENV
PhylomeDB P00751
TreeFam TF330194
BRENDA 3.4.21.47
Reactome REACT_118707
REACT_7972
REACT_8001
ChiTaRS CFB
EvolutionaryTrace P00751
GeneWiki Complement_factor_B
GenomeRNAi 629
NextBio 2546
PRO PR:P00751
Proteomes UP000005640
Bgee P00751
CleanEx HS_CFB
ExpressionAtlas P00751
Genevisible P00751
GO GO:0072562
GO:0070062
GO:0005576
GO:0005615
GO:0005886
GO:0001848
GO:0004252
GO:0006956
GO:0006957
GO:0045087
GO:0030449
Gene3D 3.40.50.410
InterPro IPR011360
IPR028341
IPR001254
IPR018114
IPR001314
IPR000436
IPR009003
IPR002035
Pfam PF00084
PF00089
PF00092
PIRSF PIRSF001154
PIRSF500181
PRINTS PR00722
SMART SM00032
SM00020
SM00327
SUPFAM SSF50494
SSF53300
SSF57535
PROSITE PS50923
PS50240
PS00134
PS00135
PS50234

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0072562

blood microparticle

PMID:22516433[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16502470[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001914)

Seeded From UniProt

complete

involved_in

GO:0006957

complement activation, alternative pathway

PMID:8225386[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR011360
InterPro:IPR018114

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011360

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114

P

Seeded From UniProt

complete

involved_in

GO:0006956

complement activation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011360

P

Seeded From UniProt

complete

enables

GO:0001848

complement binding

PMID:11367526[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030449

regulation of complement activation

Reactome:R-HSA-977606

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006957

complement activation, alternative pathway

Reactome:R-HSA-173736

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006956

complement activation

Reactome:R-HSA-174577

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-981621
Reactome:R-HSA-981535
Reactome:R-HSA-977629
Reactome:R-HSA-977619
Reactome:R-HSA-977605
Reactome:R-HSA-977375
Reactome:R-HSA-977363
Reactome:R-HSA-183122
Reactome:R-HSA-174551
Reactome:R-HSA-173754
Reactome:R-HSA-173680
Reactome:R-HSA-166817

ECO:0000304

author statement supported by traceable reference used in manual assertion












C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-981621
Reactome:R-HSA-977629
Reactome:R-HSA-977619
Reactome:R-HSA-977605
Reactome:R-HSA-183130
Reactome:R-HSA-183126
Reactome:R-HSA-183122
Reactome:R-HSA-173745
Reactome:R-HSA-173740
Reactome:R-HSA-166817

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

Reactome:R-HSA-183130

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0006957

complement activation, alternative pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0179

P

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. ↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
  3. ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
  4. ↑ Schwaeble, W et al. (1993) Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase. Immunobiology 188 221-32 PubMed GONUTS page
  5. ↑ Rawal, N & Pangburn, MK (2001) Structure/function of C5 convertases of complement. Int. Immunopharmacol. 1 415-22 PubMed GONUTS page
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