GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:CDK12
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | CDK12 (synonyms: CRK7, CRKRS, KIAA0904) | |
Protein Name(s) | Cyclin-dependent kinase 12
Cdc2-related kinase, arginine/serine-rich CrkRS Cell division cycle 2-related protein kinase 7 CDC2-related protein kinase 7 Cell division protein kinase 12 hCDK12 | |
External Links | ||
UniProt | Q9NYV4 | |
EMBL | AF227198 AB020711 AK302645 AC009283 CH471152 BC140854 BC150265 | |
CCDS | CCDS11337.1 CCDS45666.1 | |
RefSeq | NP_055898.1 NP_057591.2 | |
UniGene | Hs.416108 | |
PDB | 4CXA 4NST 4UN0 | |
PDBsum | 4CXA 4NST 4UN0 | |
ProteinModelPortal | Q9NYV4 | |
SMR | Q9NYV4 | |
BioGrid | 119715 | |
IntAct | Q9NYV4 | |
MINT | MINT-1191969 | |
STRING | 9606.ENSP00000398880 | |
PhosphoSite | Q9NYV4 | |
DMDM | 308153421 | |
MaxQB | Q9NYV4 | |
PaxDb | Q9NYV4 | |
PRIDE | Q9NYV4 | |
DNASU | 51755 | |
Ensembl | ENST00000430627 ENST00000447079 | |
GeneID | 51755 | |
KEGG | hsa:51755 | |
UCSC | uc002hrw.4 uc010cvv.3 | |
CTD | 51755 | |
GeneCards | GC17P037618 | |
H-InvDB | HIX0013777 | |
HGNC | HGNC:24224 | |
HPA | HPA008038 | |
neXtProt | NX_Q9NYV4 | |
PharmGKB | PA165431656 | |
eggNOG | COG0515 | |
GeneTree | ENSGT00770000120511 | |
HOGENOM | HOG000049118 | |
HOVERGEN | HBG050852 | |
InParanoid | Q9NYV4 | |
KO | K08819 | |
OMA | YSTRSHP | |
PhylomeDB | Q9NYV4 | |
TreeFam | TF101060 | |
BRENDA | 2.7.11.22 | |
SignaLink | Q9NYV4 | |
ChiTaRS | CDK12 | |
GeneWiki | CRKRS | |
GenomeRNAi | 51755 | |
NextBio | 55858 | |
PRO | PR:Q9NYV4 | |
Proteomes | UP000005640 | |
Bgee | Q9NYV4 | |
CleanEx | HS_CRKRS | |
ExpressionAtlas | Q9NYV4 | |
Genevestigator | Q9NYV4 | |
GO | GO:0002944 GO:0019908 GO:0016607 GO:0005730 GO:0005634 GO:0005524 GO:0030332 GO:0004693 GO:0004672 GO:0008353 GO:0006397 GO:0070816 GO:0046777 GO:0043405 GO:0008380 | |
InterPro | IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 | |
Pfam | PF00069 | |
SMART | SM00220 | |
SUPFAM | SSF56112 | |
PROSITE | PS00107 PS50011 PS00108 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0046777 |
protein autophosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070816 |
phosphorylation of RNA polymerase II C-terminal domain |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043405 |
regulation of MAP kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0019908 |
nuclear cyclin-dependent protein kinase holoenzyme complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016607 |
nuclear speck |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008353 |
RNA polymerase II CTD heptapeptide repeat kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070816 |
phosphorylation of RNA polymerase II C-terminal domain |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0037093 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070816 |
phosphorylation of RNA polymerase II C-terminal domain |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0037093 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0019949 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1328368 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032968 |
positive regulation of transcription elongation from RNA polymerase II promoter |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001936021 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0030332 |
cyclin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0037093 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008353 |
RNA polymerase II CTD heptapeptide repeat kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0019949 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008353 |
RNA polymerase II CTD heptapeptide repeat kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0019949 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000623455 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0008024 |
cyclin/CDK positive transcription elongation factor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1328368 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004106 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006368 |
transcription elongation from RNA polymerase II promoter |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0019949 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005694 |
chromosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000623455 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015618 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004693 |
cyclin-dependent protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004106 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001936021 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0000307 |
cyclin-dependent protein kinase holoenzyme complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001936021 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0030332 |
cyclin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0002944 |
cyclin K-CDK12 complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0001650 |
fibrillar center |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051726 |
regulation of cell cycle |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004693 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051726 |
regulation of cell cycle |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004693 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000737 |
negative regulation of stem cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14AX6 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q14AX6 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043484 |
regulation of RNA splicing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3MJK5 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0030332 |
cyclin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3MJK5 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0019908 |
nuclear cyclin-dependent protein kinase holoenzyme complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3MJK5 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0016607 |
nuclear speck |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3MJK5 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3MJK5 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004693 |
cyclin-dependent protein serine/threonine kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008353 |
RNA polymerase II CTD heptapeptide repeat kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6797616 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016607 |
nuclear speck |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Ko, TK et al. (2001) CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. J. Cell. Sci. 114 2591-603 PubMed GONUTS page
- ↑ 2.0 2.1 Bartkowiak, B et al. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev. 24 2303-16 PubMed GONUTS page
- ↑ Iorns, E et al. (2009) CRK7 modifies the MAPK pathway and influences the response to endocrine therapy. Carcinogenesis 30 1696-701 PubMed GONUTS page
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 Blazek, D et al. (2011) The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 25 2158-72 PubMed GONUTS page
c
- Catarrhini
- Chordata
- GO:0005694 ! chromosome
- Craniata
- GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
- GO:0004693 ! cyclin-dependent protein serine/threonine kinase activity
- GO:0008024 ! cyclin/CDK positive transcription elongation factor complex
- GO:0030332 ! cyclin binding
- GO:0002944 ! cyclin K-CDK12 complex
n
p
- GO:0016310 ! phosphorylation
- GO:0032968 ! positive regulation of transcription elongation by RNA polymerase II
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- Primates
- GO:0046777 ! protein autophosphorylation
- GO:0004672 ! protein kinase activity
- GO:0019901 ! protein kinase binding
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r
t