HUMAN:CDK12

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CDK12 (synonyms: CRK7, CRKRS, KIAA0904)
Protein Name(s)	Cyclin-dependent kinase 12 Cdc2-related kinase, arginine/serine-rich CrkRS Cell division cycle 2-related protein kinase 7 CDC2-related protein kinase 7 Cell division protein kinase 12 hCDK12
External Links
UniProt	Q9NYV4
EMBL	AF227198 AB020711 AK302645 AC009283 CH471152 BC140854 BC150265
CCDS	CCDS11337.1 CCDS45666.1
RefSeq	NP_055898.1 NP_057591.2
UniGene	Hs.416108
PDB	4CXA 4NST 4UN0
PDBsum	4CXA 4NST 4UN0
ProteinModelPortal	Q9NYV4
SMR	Q9NYV4
BioGrid	119715
IntAct	Q9NYV4
MINT	MINT-1191969
STRING	9606.ENSP00000398880
PhosphoSite	Q9NYV4
DMDM	308153421
MaxQB	Q9NYV4
PaxDb	Q9NYV4
PRIDE	Q9NYV4
DNASU	51755
Ensembl	ENST00000430627 ENST00000447079
GeneID	51755
KEGG	hsa:51755
UCSC	uc002hrw.4 uc010cvv.3
CTD	51755
GeneCards	GC17P037618
H-InvDB	HIX0013777
HGNC	HGNC:24224
HPA	HPA008038
neXtProt	NX_Q9NYV4
PharmGKB	PA165431656
eggNOG	COG0515
GeneTree	ENSGT00770000120511
HOGENOM	HOG000049118
HOVERGEN	HBG050852
InParanoid	Q9NYV4
KO	K08819
OMA	YSTRSHP
PhylomeDB	Q9NYV4
TreeFam	TF101060
BRENDA	2.7.11.22
SignaLink	Q9NYV4
ChiTaRS	CDK12
GeneWiki	CRKRS
GenomeRNAi	51755
NextBio	55858
PRO	PR:Q9NYV4
Proteomes	UP000005640
Bgee	Q9NYV4
CleanEx	HS_CRKRS
ExpressionAtlas	Q9NYV4
Genevestigator	Q9NYV4
GO	GO:0002944 GO:0019908 GO:0016607 GO:0005730 GO:0005634 GO:0005524 GO:0030332 GO:0004693 GO:0004672 GO:0008353 GO:0006397 GO:0070816 GO:0046777 GO:0043405 GO:0008380
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0046777	protein autophosphorylation	PMID:11683387^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11683387^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	PMID:20952539^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043405	regulation of MAP kinase activity	PMID:19651820^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3MJK5	C	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:11683387^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3MJK5	P	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:20952539^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037093 PANTHER:PTN001936021 SGD:S000001622 SGD:S000006365 UniProtKB:Q14004 UniProtKB:Q9NYV4	P	Seeded From UniProt	complete
involved_in	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037093 PANTHER:PTN000623455 SGD:S000001622 SGD:S000006365 UniProtKB:Q14004 UniProtKB:Q9NYV4	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 PANTHER:PTN000623455 UniProtKB:P50750	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1328368 PANTHER:PTN000623455	F	Seeded From UniProt	complete
involved_in	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001936021 SGD:S000006365	P	Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037093 MGI:MGI:1916812 PANTHER:PTN000623455 RGD:621111 UniProtKB:Q14004 UniProtKB:Q9NYV4	F	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 FB:FBgn0037093 MGI:MGI:1328368 PANTHER:PTN001936021 PomBase:SPAC2F3.15 PomBase:SPBC32H8.10 SGD:S000006365 UniProtKB:P50750 UniProtKB:Q14004 UniProtKB:Q9NYV4	F	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 FB:FBgn0037093 MGI:MGI:1328368 PANTHER:PTN000623455 PomBase:SPAC2F3.15 PomBase:SPBC32H8.10 SGD:S000006365 UniProtKB:P50750 UniProtKB:Q14004 UniProtKB:Q9NYV4	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000623455 RGD:1359638	F	Seeded From UniProt	complete
part_of	GO:0008024	cyclin/CDK positive transcription elongation factor complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1328368 PANTHER:PTN000623455 UniProtKB:P50750	C	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013435 FB:FBgn0013762 FB:FBgn0015618 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 RGD:621124 RGD:70514 SGD:S000001622 SGD:S000001865 SGD:S000005488 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2119961 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q9UQ88 WB:WBGene00000405 WB:WBGene00000407 WB:WBGene00019362 ZFIN:ZDB-GENE-040808-34 dictyBase:DDB_G0267442 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	P	Seeded From UniProt	complete
involved_in	GO:0006368	transcription elongation from RNA polymerase II promoter	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 PANTHER:PTN000623455	P	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000623455 WB:WBGene00000410 WB:WBGene00007135	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015618 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:102956 MGI:MGI:104772 MGI:MGI:1328368 MGI:MGI:88353 MGI:MGI:88357 MGI:MGI:894318 PANTHER:PTN000623091 PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC32H8.10 RGD:1305435 RGD:1359638 RGD:2319 RGD:619874 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000002266 SGD:S000005952 TAIR:locus:2008595 TAIR:locus:2027819 TAIR:locus:2033349 TAIR:locus:2080290 TAIR:locus:2084086 TAIR:locus:2099478 TAIR:locus:2119961 TAIR:locus:2158554 TAIR:locus:2194045 UniProtKB:O76039 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P49336 UniProtKB:P50613 UniProtKB:P61075 UniProtKB:P79432 UniProtKB:Q00534 UniProtKB:Q00535 UniProtKB:Q00646 UniProtKB:Q5B3E4 UniProtKB:Q8IDW1 UniProtKB:Q8IIL5 UniProtKB:Q8IJQ1 UniProtKB:Q8RWN3 UniProtKB:Q8W4P1 UniProtKB:Q92772 UniProtKB:Q96VK3 UniProtKB:Q9NYV4 UniProtKB:Q9UQ88 WB:WBGene00000405 dictyBase:DDB_G0267442 dictyBase:DDB_G0288677	C	Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013762 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 PomBase:SPAC23H4.17c PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC19F8.07 PomBase:SPBC32H8.10 RGD:2319 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2011761 UniProtKB:A0A1D8PDA6 UniProtKB:C9K505 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:P61075 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q8IJQ1 WB:WBGene00000405 ZFIN:ZDB-GENE-010131-2 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001936021 PomBase:SPAC2F3.15 PomBase:SPBC32H8.10	C	Seeded From UniProt	complete
part_of	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001936021 PomBase:SPBC32H8.10 SGD:S000006365	C	Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:22012619^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75909	F	Seeded From UniProt	complete
part_of	GO:0002944	cyclin K-CDK12 complex	PMID:22012619^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75909	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004693	P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004693	P	Seeded From UniProt	complete
involved_in	GO:2000737	negative regulation of stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14AX6 ensembl:ENSMUSP00000103162	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14AX6 ensembl:ENSMUSP00000103162	F	Seeded From UniProt	complete
involved_in	GO:0043484	regulation of RNA splicing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3MJK5 ensembl:ENSRNOP00000008256	P	Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3MJK5 ensembl:ENSRNOP00000008256	F	Seeded From UniProt	complete
part_of	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3MJK5 ensembl:ENSRNOP00000008256	C	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3MJK5 ensembl:ENSRNOP00000008256	C	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3MJK5 ensembl:ENSRNOP00000008256	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P	Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.22	F	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.23	F	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6797616 Reactome:R-HSA-6797606 Reactome:R-HSA-6797090	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0508	P	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Ko, TK et al. (2001) CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. J. Cell. Sci. 114 2591-603 PubMed GONUTS page
↑ ^2.0 ^2.1 Bartkowiak, B et al. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev. 24 2303-16 PubMed GONUTS page
↑ Iorns, E et al. (2009) CRK7 modifies the MAPK pathway and influences the response to endocrine therapy. Carcinogenesis 30 1696-701 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Blazek, D et al. (2011) The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 25 2158-72 PubMed GONUTS page

[PMID:11683387-1] 1.0 ^1.1 ^1.2 Ko, TK et al. (2001) CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. J. Cell. Sci. 114 2591-603 PubMed GONUTS page

[PMID:20952539-2] 2.0 ^2.1 Bartkowiak, B et al. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev. 24 2303-16 PubMed GONUTS page

[PMID:19651820-3] Iorns, E et al. (2009) CRK7 modifies the MAPK pathway and influences the response to endocrine therapy. Carcinogenesis 30 1696-701 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22012619-5] 5.0 ^5.1 Blazek, D et al. (2011) The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 25 2158-72 PubMed GONUTS page

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HUMAN:CDK12

Contents

Annotations

Notes

References

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