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HUMAN:CDC37

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CDC37 (synonyms: CDC37A)
Protein Name(s) Hsp90 co-chaperone Cdc37

Hsp90 chaperone protein kinase-targeting subunit p50Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed

External Links
UniProt Q16543
EMBL U43077
U63131
AY864824
BT006796
CH471106
BC000083
BC008793
CCDS CCDS12237.1
PIR G02313
RefSeq NP_008996.1
UniGene Hs.160958
PDB 1US7
2K5B
2W0G
PDBsum 1US7
2K5B
2W0G
ProteinModelPortal Q16543
SMR Q16543
BioGrid 116312
DIP DIP-27560N
DIP-395N
IntAct Q16543
MINT MINT-99762
STRING 9606.ENSP00000222005
ChEMBL CHEMBL1795123
PhosphoSite Q16543
DMDM 21542000
MaxQB Q16543
PaxDb Q16543
PeptideAtlas Q16543
PRIDE Q16543
DNASU 11140
Ensembl ENST00000222005
GeneID 11140
KEGG hsa:11140
UCSC uc002mof.1
CTD 11140
GeneCards GC19M010501
HGNC HGNC:1735
HPA CAB004214
HPA003928
MIM 605065
neXtProt NX_Q16543
PharmGKB PA402
eggNOG NOG300020
GeneTree ENSGT00390000013443
HOGENOM HOG000018180
HOVERGEN HBG056343
InParanoid Q16543
KO K09554
OrthoDB EOG73805G
PhylomeDB Q16543
TreeFam TF101059
Reactome REACT_115755
REACT_115852
ChiTaRS CDC37
EvolutionaryTrace Q16543
GeneWiki CDC37
GenomeRNAi 11140
NextBio 42344
PRO PR:Q16543
Proteomes UP000005640
Bgee Q16543
CleanEx HS_CDC37
ExpressionAtlas Q16543
Genevestigator Q16543
GO GO:0005737
GO:0005829
GO:0070062
GO:0043234
GO:0032587
GO:0031072
GO:0051082
GO:0006605
GO:0000079
GO:0060334
GO:0060338
InterPro IPR004918
IPR013873
IPR013874
IPR013855
PANTHER PTHR12800
Pfam PF08564
PF08565
PF03234
SMART SM01069
SM01070
SM01071

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0097110

scaffold protein binding

PMID:10409742[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q61097

F

Seeded From UniProt

complete

part_of

GO:1990565

HSP90-CDC37 chaperone complex

PMID:21855797[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0101031

chaperone complex

PMID:29127155[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

PMID:21855797[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O70405

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0031072

heat shock protein binding

PMID:9660753[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P07900

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000980613
RGD:71006

F

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000192456
PANTHER:PTN000980613
SGD:S000002575

F

Seeded From UniProt

complete

involved_in

GO:0050821

protein stabilization

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000980613
SGD:S000002575

P

Seeded From UniProt

complete

enables

GO:0031072

heat shock protein binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000980613
PomBase:SPBC9B6.10
UniProtKB:Q16543

F

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000980613
PomBase:SPBC9B6.10

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914322
PANTHER:PTN000980613
PomBase:SPBC9B6.10
RGD:71006
UniProtKB:Q16543
WB:WBGene00021097

C

Seeded From UniProt

complete

involved_in

GO:0060338

regulation of type I interferon-mediated signaling pathway

PMID:16280321[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060334

regulation of interferon-gamma-mediated signaling pathway

PMID:16280321[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1990565

HSP90-CDC37 chaperone complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61081
ensembl:ENSMUSP00000019615

C

Seeded From UniProt

complete

involved_in

GO:0098779

positive regulation of mitophagy in response to mitochondrial depolarization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61081
ensembl:ENSMUSP00000019615

P

Seeded From UniProt

complete

enables

GO:0051879

Hsp90 protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61081
ensembl:ENSMUSP00000019615

F

Seeded From UniProt

complete

involved_in

GO:0045859

regulation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61081
ensembl:ENSMUSP00000019615

P

Seeded From UniProt

complete

enables

GO:0019900

kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61081
ensembl:ENSMUSP00000019615

F

Seeded From UniProt

complete

enables

GO:0019887

protein kinase regulator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61081
ensembl:ENSMUSP00000019615

F

Seeded From UniProt

complete

involved_in

GO:0010608

posttranscriptional regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61081
ensembl:ENSMUSP00000019615

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61081
ensembl:ENSMUSP00000019615

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013855

F

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

PMID:8666233[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006605

protein targeting

PMID:8666233[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:8666233[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038128

ERBB2 signaling pathway

Reactome:R-HSA-1227986

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5638137
Reactome:R-HSA-5637808
Reactome:R-HSA-5637806
Reactome:R-HSA-5637801
Reactome:R-HSA-5637800
Reactome:R-HSA-5637798
Reactome:R-HSA-5637796
Reactome:R-HSA-5637795
Reactome:R-HSA-5637794
Reactome:R-HSA-5637792
Reactome:R-HSA-5637770
Reactome:R-HSA-5637766
Reactome:R-HSA-5637765
Reactome:R-HSA-5637764
Reactome:R-HSA-1963589
Reactome:R-HSA-1918095
Reactome:R-HSA-1918092
Reactome:R-HSA-1248655
Reactome:R-HSA-1248002
Reactome:R-HSA-1247999
Reactome:R-HSA-1247844
Reactome:R-HSA-1247842
Reactome:R-HSA-1247841
Reactome:R-HSA-1226016
Reactome:R-HSA-1226014
Reactome:R-HSA-1226012
Reactome:R-HSA-1225961
Reactome:R-HSA-1225960
Reactome:R-HSA-1225957
Reactome:R-HSA-1225956
Reactome:R-HSA-1225952
Reactome:R-HSA-1225951
Reactome:R-HSA-1225950
Reactome:R-HSA-1225949
Reactome:R-HSA-1225947
Reactome:R-HSA-1220614
Reactome:R-HSA-1220613
Reactome:R-HSA-1220612
Reactome:R-HSA-1220611
Reactome:R-HSA-1220610
Reactome:R-HSA-1218833
Reactome:R-HSA-1169421

ECO:0000304

author statement supported by traceable reference used in manual assertion










































C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Stewart, S et al. (1999) Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol. Cell. Biol. 19 5523-34 PubMed GONUTS page
  2. ↑ 2.0 2.1 Joo, JH et al. (2011) Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol. Cell 43 572-85 PubMed GONUTS page
  3. ↑ Woodford, MR et al. (2017) Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. EMBO J. 36 3650-3665 PubMed GONUTS page
  4. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  5. ↑ Young, JC et al. (1998) Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. J. Biol. Chem. 273 18007-10 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 Shang, L & Tomasi, TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J. Biol. Chem. 281 1876-84 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Stepanova, L et al. (1996) Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev. 10 1491-502 PubMed GONUTS page
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