HUMAN:CCNF

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CCNF (synonyms: FBX1, FBXO1)
Protein Name(s)	Cyclin-F F-box only protein 1
External Links
UniProt	P41002
EMBL	U17105 Z36714 AK313371 AC106820 BC012349
CCDS	CCDS10467.1
PIR	A55501
RefSeq	NP_001752.2
UniGene	Hs.1973
ProteinModelPortal	P41002
SMR	P41002
BioGrid	107339
DIP	DIP-44939N
IntAct	P41002
MINT	MINT-1543357
STRING	9606.ENSP00000380256
PhosphoSite	P41002
DMDM	20178283
MaxQB	P41002
PaxDb	P41002
PRIDE	P41002
DNASU	899
Ensembl	ENST00000397066
GeneID	899
KEGG	hsa:899
UCSC	uc002cqd.1
CTD	899
GeneCards	GC16P002479
HGNC	HGNC:1591
MIM	600227
neXtProt	NX_P41002
PharmGKB	PA26156
eggNOG	NOG283043
GeneTree	ENSGT00730000111208
HOGENOM	HOG000285971
HOVERGEN	HBG050838
InParanoid	P41002
KO	K10289
OMA	KSCLQCR
OrthoDB	EOG7WDN1V
PhylomeDB	P41002
TreeFam	TF101006
SignaLink	P41002
ChiTaRS	CCNF
GeneWiki	CCNF
GenomeRNAi	899
NextBio	3714
PRO	PR:P41002
Proteomes	UP000005640
Bgee	P41002
CleanEx	HS_CCNF
ExpressionAtlas	P41002
Genevestigator	P41002
GO	GO:0005814 GO:0005634 GO:0019005 GO:0007067 GO:0010826 GO:0001890 GO:0016567 GO:0000320 GO:0031146
Gene3D	1.10.472.10 1.25.40.10
InterPro	IPR028857 IPR013763 IPR004367 IPR006671 IPR001810 IPR011990
PANTHER	PTHR10177:SF183
Pfam	PF02984 PF00134 PF00646
SMART	SM00385 SM00256
SUPFAM	SSF47954 SSF81383
PROSITE	PS00292 PS50181

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PMID:20596027^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0019005	SCF ubiquitin ligase complex	PMID:20596027^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:20596027^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010826	negative regulation of centrosome duplication	PMID:20596027^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005814	centriole	PMID:20596027^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20596027^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88302 PANTHER:PTN000019791	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108069 MGI:MGI:88313 MGI:MGI:88315 MGI:MGI:88316 PANTHER:PTN000019791 RGD:1307783 RGD:2291 RGD:2293 RGD:2294 RGD:621083 RGD:68384 UniProtKB:P14635 UniProtKB:P20248 UniProtKB:P24385 UniProtKB:P30279 UniProtKB:P30281	F	Seeded From UniProt	complete
enables	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000175354 FB:FBgn0000404 FB:FBgn0000405 FB:FBgn0010315 FB:FBgn0010317 FB:FBgn0010382 MGI:MGI:1329034 MGI:MGI:88313 MGI:MGI:88316 PANTHER:PTN000019791 PomBase:SPBC19F5.01c SGD:S000000038 SGD:S000002314 SGD:S000003340 SGD:S000003341 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 SGD:S000006324 WB:WBGene00000865 WB:WBGene00000868 WB:WBGene00000871	F	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000019791 RGD:2293 RGD:621083 RGD:68384 UniProtKB:P30279 WB:WBGene00000871	P	Seeded From UniProt	complete
involved_in	GO:0007088	regulation of mitotic nuclear division	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 PANTHER:PTN000019791 WB:WBGene00000871	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000808648 UniProtKB:P41002	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 MGI:MGI:108069 MGI:MGI:2145534 MGI:MGI:88302 MGI:MGI:88313 MGI:MGI:88314 MGI:MGI:88315 PANTHER:PTN000019791 PomBase:SPBC582.03 RGD:2291 RGD:2294 RGD:68384 SGD:S000002314 SGD:S000003340 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 TAIR:locus:2031407 TAIR:locus:2142504 TAIR:locus:2160722 TAIR:locus:2205871 UniProtKB:P14635 UniProtKB:P20248 UniProtKB:P22674 UniProtKB:Q9C6A9 WB:WBGene00000865 WB:WBGene00000868	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 FB:FBgn0000405 FB:FBgn0010382 FB:FBgn0015625 MGI:MGI:108069 MGI:MGI:88302 MGI:MGI:88313 MGI:MGI:88314 MGI:MGI:88315 MGI:MGI:88316 PANTHER:PTN000019791 PomBase:SPBC582.03 RGD:2291 RGD:2294 RGD:2295 RGD:621059 RGD:68384 SGD:S000000038 SGD:S000002314 SGD:S000003340 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 SGD:S000006324 TAIR:locus:2031407 TAIR:locus:2034250 TAIR:locus:2120081 TAIR:locus:2124331 TAIR:locus:2142504 TAIR:locus:2196563 TAIR:locus:2205871 UniProtKB:P14635 UniProtKB:P20248 UniProtKB:P24385 UniProtKB:P24864 UniProtKB:P30279 UniProtKB:P41002 UniProtKB:Q9C6A9 WB:WBGene00000865 WB:WBGene00000868 WB:WBGene00000871	C	Seeded From UniProt	complete
contributes_to	GO:0004672	protein kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88313 PANTHER:PTN000019791	F	Seeded From UniProt	complete
part_of	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88313 MGI:MGI:88316 PANTHER:PTN000019791 PomBase:SPAPB2B4.03 SGD:S000003340 SGD:S000006177 UniProtKB:P20248 UniProtKB:P24385 UniProtKB:P30279 UniProtKB:P30281 UniProtKB:P43449	C	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000404 FB:FBgn0010317 FB:FBgn0015625 PANTHER:PTN000019791 RGD:2291 UniProtKB:P22674 WB:WBGene00000865 WB:WBGene00000868	P	Seeded From UniProt	complete
involved_in	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000175354 CGD:CAL0000185532 PANTHER:PTN000019791 SGD:S000000038 SGD:S000002314 SGD:S000003340 SGD:S000003341 SGD:S000004200 SGD:S000004812 SGD:S000006177 SGD:S000006323 SGD:S000006324 UniProtKB:Q59YH3	P	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004672	P	Seeded From UniProt	complete
involved_in	GO:0010826	negative regulation of centrosome duplication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51944 ensembl:ENSMUSP00000111048	P	Seeded From UniProt	complete
involved_in	GO:0001890	placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51944 ensembl:ENSMUSP00000111048	P	Seeded From UniProt	complete
involved_in	GO:0000320	re-entry into mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51944 ensembl:ENSMUSP00000111048	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004367	C	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028857	P	Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-983157 Reactome:R-HSA-983156 Reactome:R-HSA-983147 Reactome:R-HSA-983140 Reactome:R-HSA-8956200 Reactome:R-HSA-8956040 Reactome:R-HSA-8955289 Reactome:R-HSA-8955241 Reactome:R-HSA-8952620 Reactome:R-HSA-8952618	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	Reactome:R-HSA-983168	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0046	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 D'Angiolella, V et al. (2010) SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 466 138-42 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20596027-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 D'Angiolella, V et al. (2010) SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 466 138-42 PubMed GONUTS page

[PMID:21873635-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:CCNF

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