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HUMAN:CALY
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CALY (synonyms: DRD1IP) | |
| Protein Name(s) | Neuron-specific vesicular protein calcyon | |
| External Links | ||
| UniProt | Q9NYX4 | |
| EMBL | AF225903 AL360181 AL360181 AL360181 CH471211 BC038978 | |
| CCDS | CCDS7678.1 | |
| RefSeq | NP_056537.1 | |
| UniGene | Hs.148680 | |
| ProteinModelPortal | Q9NYX4 | |
| IntAct | Q9NYX4 | |
| MINT | MINT-123006 | |
| STRING | 9606.ENSP00000252939 | |
| DrugBank | DB05419 DB00714 DB00363 DB05432 DB00831 | |
| iPTMnet | Q9NYX4 | |
| PhosphoSitePlus | Q9NYX4 | |
| BioMuta | CALY | |
| DMDM | 17374622 | |
| PaxDb | Q9NYX4 | |
| PeptideAtlas | Q9NYX4 | |
| PRIDE | Q9NYX4 | |
| Ensembl | ENST00000252939 ENST00000368555 ENST00000368558 | |
| GeneID | 50632 | |
| KEGG | hsa:50632 | |
| UCSC | uc001lmo.3 | |
| CTD | 50632 | |
| DisGeNET | 50632 | |
| GeneCards | CALY | |
| HGNC | HGNC:17938 | |
| HPA | HPA042283 | |
| MIM | 604647 | |
| neXtProt | NX_Q9NYX4 | |
| OpenTargets | ENSG00000130643 | |
| PharmGKB | PA162380987 | |
| eggNOG | ENOG410IKA7 ENOG41118NY | |
| GeneTree | ENSGT00390000000483 | |
| HOGENOM | HOG000030909 | |
| HOVERGEN | HBG012403 | |
| InParanoid | Q9NYX4 | |
| KO | K15493 | |
| OMA | CLLIMYK | |
| OrthoDB | EOG091G0KES | |
| PhylomeDB | Q9NYX4 | |
| TreeFam | TF332232 | |
| GeneWiki | DRD1IP | |
| GenomeRNAi | 50632 | |
| PRO | PR:Q9NYX4 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000130643 | |
| CleanEx | HS_CALY | |
| Genevisible | Q9NYX4 | |
| GO | GO:0031410 GO:0030659 GO:0005768 GO:0005887 GO:0032051 GO:0048268 GO:0007212 GO:0006897 GO:0016197 GO:0045807 | |
| InterPro | IPR009431 | |
| Pfam | PF06387 | |
| PIRSF | PIRSF002383 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
Contributes to |
GO:0003824 |
alpha-1,3-mannosyltransferase activity |
ECO:0000247 |
|
F |
Figure 6. Non mutated allele in the GLA gene was methylated, compared to the non-mutated allele in the GLA gene in related patients which was not methylated resulting in more severe clinical phenotypes |
complete | |||
|
involved_in |
GO:0048268 |
clathrin coat assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045807 |
positive regulation of endocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032051 |
clathrin light chain binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098843 |
postsynaptic endocytic zone |
ECO:0006063 |
over expression analysis evidence used in manual assertion |
C |
part_of:(UBERON:0001950) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098843 |
postsynaptic endocytic zone |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0001950) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098843 |
postsynaptic endocytic zone |
ECO:0005589 |
confocal microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0001950) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048268 |
clathrin coat assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002004166 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0032051 |
clathrin light chain binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002004166 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016197 |
endosomal transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002004166 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005768 |
endosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109149 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P58821 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9DCA7 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0098884 |
postsynaptic neurotransmitter receptor internalization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9DCA7 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0038024 |
cargo receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9DCA7 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007212 |
dopamine receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032051 |
clathrin light chain binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048268 |
clathrin coat assembly |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030659 |
cytoplasmic vesicle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hossain, MA et al. (2017) The severe clinical phenotype for a heterozygous Fabry female patient correlates to the methylation of non-mutated allele associated with chromosome 10q26 deletion syndrome. Mol. Genet. Metab. 120 173-179 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Xiao, J et al. (2006) Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis. J. Biol. Chem. 281 15182-93 PubMed GONUTS page
- ↑ 3.0 3.1 Ali, MK & Bergson, C (2003) Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane. J. Biol. Chem. 278 51654-63 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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