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HUMAN:BRMS1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) BRMS1
Protein Name(s) Breast cancer metastasis-suppressor 1
External Links
UniProt Q9HCU9
EMBL AF159141
AF281036
CR457173
AK313773
BC009834
CCDS CCDS8135.1
RefSeq NP_056214.1
UniGene Hs.100426
PDB 2XUS
4AUV
PDBsum 2XUS
4AUV
ProteinModelPortal Q9HCU9
SMR Q9HCU9
BioGrid 117379
DIP DIP-24250N
IntAct Q9HCU9
MINT MINT-1389009
STRING 9606.ENSP00000396052
PhosphoSite Q9HCU9
DMDM 18202959
MaxQB Q9HCU9
PaxDb Q9HCU9
PRIDE Q9HCU9
DNASU 25855
Ensembl ENST00000359957
GeneID 25855
KEGG hsa:25855
UCSC uc001ohp.1
CTD 25855
GeneCards GC11M066104
HGNC HGNC:17262
HPA CAB010824
HPA019637
MIM 606259
neXtProt NX_Q9HCU9
PharmGKB PA164741342
eggNOG NOG260250
GeneTree ENSGT00530000063177
HOGENOM HOG000007483
HOVERGEN HBG050734
InParanoid Q9HCU9
PhylomeDB Q9HCU9
Reactome REACT_228222
EvolutionaryTrace Q9HCU9
GeneWiki BRMS1
GenomeRNAi 25855
NextBio 47213
PRO PR:Q9HCU9
Proteomes UP000005640
Bgee Q9HCU9
CleanEx HS_BRMS1
ExpressionAtlas Q9HCU9
Genevestigator Q9HCU9
GO GO:0005737
GO:0005634
GO:0051059
GO:0006915
GO:0032088
GO:0045892
GO:2000210
GO:0090312
GO:0006351
InterPro IPR013907
Pfam PF08598

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:2000210

positive regulation of anoikis

PMID:17000776[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090312

positive regulation of protein deacetylation

PMID:17000776[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051059

NF-kappaB binding

PMID:17000776[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:20830743[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:17000776[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

PMID:17000776[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20830743[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17000776[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20830743[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070822

Sin3-type complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0030434
FB:FBgn0031036
PANTHER:PTN001095090

C

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919204
PANTHER:PTN001095090

F

Seeded From UniProt

complete

involved_in

GO:0016575

histone deacetylation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001095090
SGD:S000000011
SGD:S000001346
UniProtKB:Q9H7L9

P

Seeded From UniProt

complete

contributes_to

GO:0004407

histone deacetylase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001095090
SGD:S000001346
UniProtKB:Q9H7L9

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001095090
SGD:S000000011
SGD:S000001346
UniProtKB:Q9H7L9

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-3769447

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Liu, Y et al. (2006) Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis. Mol. Cell. Biol. 26 8683-96 PubMed GONUTS page
  2. 2.0 2.1 2.2 Rivera, J et al. (2010) Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression. J. Cell. Biochem. 111 1464-72 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page