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HUMAN:BMP1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) BMP1 (synonyms: PCOLC)
Protein Name(s) Bone morphogenetic protein 1

BMP-1 Mammalian tolloid protein mTld Procollagen C-proteinase PCP

External Links
UniProt P13497
EMBL U50330
M22488
Y08723
Y08724
Y08725
L35278
L35279
AK291620
CH471080
CH471080
CH471080
BC136679
CCDS CCDS34856.1
CCDS6026.1
PIR A37278
A58788
B58788
RefSeq NP_001190.1
NP_006120.1
UniGene Hs.1274
PDB 3EDG
3EDH
PDBsum 3EDG
3EDH
ProteinModelPortal P13497
SMR P13497
BioGrid 107117
DIP DIP-33403N
IntAct P13497
MINT MINT-1394084
STRING 9606.ENSP00000305714
BindingDB P13497
ChEMBL CHEMBL3898
MEROPS M12.005
PhosphoSite P13497
DMDM 13124688
MaxQB P13497
PaxDb P13497
PeptideAtlas P13497
PRIDE P13497
Ensembl ENST00000306349
ENST00000306385
ENST00000471755
ENST00000520970
ENST00000521385
GeneID 649
KEGG hsa:649
UCSC uc003xbb.3
uc003xbg.3
CTD 649
GeneCards GC08P022022
HGNC HGNC:1067
HPA HPA014572
MIM 112264
614856
neXtProt NX_P13497
Orphanet 216812
PharmGKB PA25377
eggNOG NOG70307
GeneTree ENSGT00760000119018
HOVERGEN HBG004859
InParanoid P13497
KO K05502
OMA RGRFCGG
OrthoDB EOG7N8ZTV
PhylomeDB P13497
TreeFam TF314351
BRENDA 3.4.24.19
Reactome REACT_118572
REACT_121139
REACT_13621
REACT_150206
REACT_150268
ChiTaRS BMP1
EvolutionaryTrace P13497
GeneWiki Bone_morphogenetic_protein_1
GenomeRNAi 649
NextBio 2632
PMAP-CutDB P13497
PRO PR:P13497
Proteomes UP000005640
Bgee P13497
CleanEx HS_BMP1
ExpressionAtlas P13497
Genevestigator P13497
GO GO:0005576
GO:0005615
GO:0005794
GO:0031988
GO:0005578
GO:0005509
GO:0004222
GO:0008237
GO:0008233
GO:0008270
GO:0001502
GO:0030154
GO:0022617
GO:0030198
GO:0042157
GO:0007275
GO:0001503
GO:0061036
GO:0006508
GO:0001501
GO:0044281
Gene3D 2.60.120.290
3.40.390.10
InterPro IPR029837
IPR015446
IPR000859
IPR000742
IPR001881
IPR013032
IPR000152
IPR018097
IPR009030
IPR024079
IPR001506
IPR006026
PANTHER PTHR10127:SF305
Pfam PF01400
PF00431
PF07645
PIRSF PIRSF001199
PRINTS PR00480
SMART SM00042
SM00179
SM00235
SUPFAM SSF49854
SSF57184
PROSITE PS00010
PS01180
PS01186
PS50026
PS01187
PS00142

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0008237

metallopeptidase activity

PMID:7798260[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

PMID:16824737[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:16824737[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001501

skeletal system development

PMID:7798260[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061036

positive regulation of cartilage development

PMID:3201241[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

PMID:12393877[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:19429706[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P13497

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

part_of

GO:0031982

vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M798
ensembl:ENSRNOP00000040287

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M798
ensembl:ENSRNOP00000040287

C

Seeded From UniProt

complete

enables

GO:0004222

metalloendopeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P98063
ensembl:ENSMUSP00000022693

F

Seeded From UniProt

complete

enables

GO:0004222

metalloendopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001506
InterPro:IPR015446

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001881
InterPro:IPR018097

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001506
InterPro:IPR006026

P

Seeded From UniProt

complete

enables

GO:0008237

metallopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006026
InterPro:IPR024079

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006026

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

PMID:8553073[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

PMID:7798260[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001502

cartilage condensation

PMID:3201241[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001501

skeletal system development

PMID:3201241[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034380

high-density lipoprotein particle assembly

Reactome:R-HSA-8963896

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0022617

extracellular matrix disassembly

Reactome:R-HSA-1474228

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-3814820
Reactome:R-HSA-264758
Reactome:R-HSA-2214330
Reactome:R-HSA-2022141
Reactome:R-HSA-2002440
Reactome:R-HSA-2002428

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0891

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0892

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

enables

GO:0008237

metallopeptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0482

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Takahara, K et al. (1994) Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. J. Biol. Chem. 269 32572-8 PubMed GONUTS page
  2. 2.0 2.1 Jasuja, R et al. (2006) bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Mech. Dev. 123 548-58 PubMed GONUTS page
  3. 3.0 3.1 3.2 Wozney, JM et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242 1528-34 PubMed GONUTS page
  4. Steiglitz, BM et al. (2002) PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. J. Biol. Chem. 277 49820-30 PubMed GONUTS page
  5. Berry, R et al. (2009) Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid. Proc. Natl. Acad. Sci. U.S.A. 106 8561-6 PubMed GONUTS page
  6. Kessler, E et al. (1996) Bone morphogenetic protein-1: the type I procollagen C-proteinase. Science 271 360-2 PubMed GONUTS page