HUMAN:B4DP05

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FMN2
Protein Name(s)	Formin-2 cDNA FLJ60748, highly similar to Homo sapiens formin 2 (FMN2), mRNA
External Links
UniProt	B4DP05
EMBL	AL356361 AL359918 AL513342 AL590490 AL646016 AK298141
UniGene	Hs.24889
Ensembl	ENST00000545751
UCSC	uc010pyg.2
HGNC	HGNC:14074
HOVERGEN	HBG106052
NextBio	35473751
GO	GO:0005884 GO:0045010
InterPro	IPR015425 IPR001265
Pfam	PF02181
PRINTS	PR00828
SMART	SM00498
PROSITE	PS51444

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006473	protein acetylation	PMID:23110170^[1]	ECO:0000250			P	Figure 4 shows acetylation of microtubules with formin derivatives. Formin-2's role in acetylation is assumed from this data.	Missing: with/from CACAO 7857
involved_in	GO:2000781	positive regulation of double-strand break repair	PMID:26287480^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070649	formin-nucleated actin cable assembly	PMID:26287480^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:26287480^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26287480^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051758	homologous chromosome movement towards spindle pole involved in homologous chromosome segregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JL04	P	Seeded From UniProt	complete
involved_in	GO:0051295	establishment of meiotic spindle localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JL04	P	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JL04	P	Seeded From UniProt	complete
involved_in	GO:0040038	polar body extrusion after meiotic divisions	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JL04	P	Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:23375502^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070649	formin-nucleated actin cable assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JL04	P	Seeded From UniProt	complete
involved_in	GO:0046907	intracellular transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JL04	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:23375502^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	PMID:23375502^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JL04	C	Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JL04	P	Seeded From UniProt	complete
colocalizes_with	GO:0015629	actin cytoskeleton	PMID:20082305^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:23375502^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JL04	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:20082305^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:23375502^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:20082305^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070649	formin-nucleated actin cable assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	P	Seeded From UniProt	complete
involved_in	GO:0051758	homologous chromosome movement towards spindle pole involved in homologous chromosome segregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	P	Seeded From UniProt	complete
involved_in	GO:0051295	establishment of meiotic spindle localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	P	Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	P	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	P	Seeded From UniProt	complete
involved_in	GO:0046907	intracellular transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	P	Seeded From UniProt	complete
involved_in	GO:0040038	polar body extrusion after meiotic divisions	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	P	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	C	Seeded From UniProt	complete
involved_in	GO:0016344	meiotic chromosome movement towards spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	P	Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	P	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	C	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JL04 ensembl:ENSMUSP00000030039	C	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000591	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Thurston, SF et al. (2012) The ability to induce microtubule acetylation is a general feature of formin proteins. PLoS ONE 7 e48041 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Belin, BJ et al. (2015) DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected]. Elife 4 e07735 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Yamada, K et al. (2013) Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21. Mol. Cell 49 922-33 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Shieh, DB et al. (2010) Effects of genistein on beta-catenin signaling and subcellular distribution of actin-binding proteins in human umbilical CD105-positive stromal cells. J. Cell. Physiol. 223 423-34 PubMed GONUTS page

[PMID:23110170-1] Thurston, SF et al. (2012) The ability to induce microtubule acetylation is a general feature of formin proteins. PLoS ONE 7 e48041 PubMed GONUTS page

[PMID:26287480-2] 2.0 ^2.1 ^2.2 ^2.3 Belin, BJ et al. (2015) DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected]. Elife 4 e07735 PubMed GONUTS page

[PMID:23375502-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Yamada, K et al. (2013) Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21. Mol. Cell 49 922-33 PubMed GONUTS page

[PMID:20082305-4] 4.0 ^4.1 ^4.2 Shieh, DB et al. (2010) Effects of genistein on beta-catenin signaling and subcellular distribution of actin-binding proteins in human umbilical CD105-positive stromal cells. J. Cell. Physiol. 223 423-34 PubMed GONUTS page

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HUMAN:B4DP05

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