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HUMAN:AUTS2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | AUTS2 (synonyms: KIAA0442) | |
| Protein Name(s) | Autism susceptibility gene 2 protein | |
| External Links | ||
| UniProt | Q8WXX7 | |
| EMBL | JQ670866 JQ670867 AF326917 AB007902 AC004773 AC004881 AC004927 AC006012 AC006317 AC006318 AC006319 AC006361 AC073148 AC073873 AC093487 AC093679 AC093685 CH236952 BC011643 BC064693 | |
| CCDS | CCDS47601.1 CCDS47602.1 CCDS5539.1 | |
| PIR | T00065 | |
| RefSeq | NP_001120703.1 NP_001120704.1 NP_056385.1 | |
| UniGene | Hs.21631 Hs.712991 | |
| ProteinModelPortal | Q8WXX7 | |
| BioGrid | 117516 | |
| IntAct | Q8WXX7 | |
| STRING | 9606.ENSP00000344087 | |
| PhosphoSite | Q8WXX7 | |
| DMDM | 23396464 | |
| PaxDb | Q8WXX7 | |
| PRIDE | Q8WXX7 | |
| Ensembl | ENST00000342771 ENST00000403018 ENST00000406775 | |
| GeneID | 26053 | |
| KEGG | hsa:26053 | |
| UCSC | uc003tvv.4 uc003tvw.4 uc003tvx.4 | |
| CTD | 26053 | |
| GeneCards | GC07P069063 | |
| HGNC | HGNC:14262 | |
| HPA | HPA000390 | |
| MIM | 607270 615834 | |
| neXtProt | NX_Q8WXX7 | |
| Orphanet | 106 352490 99860 | |
| PharmGKB | PA134863175 | |
| eggNOG | NOG41815 | |
| GeneTree | ENSGT00390000001466 | |
| HOGENOM | HOG000143450 | |
| HOVERGEN | HBG050644 | |
| InParanoid | Q8WXX7 | |
| OMA | YEADRSF | |
| OrthoDB | EOG7CG6ZH | |
| PhylomeDB | Q8WXX7 | |
| TreeFam | TF331929 | |
| ChiTaRS | AUTS2 | |
| GenomeRNAi | 26053 | |
| NextBio | 47920 | |
| PRO | PR:Q8WXX7 | |
| Proteomes | UP000005640 | |
| Bgee | Q8WXX7 | |
| CleanEx | HS_AUTS2 | |
| ExpressionAtlas | Q8WXX7 | |
| Genevestigator | Q8WXX7 | |
| InterPro | IPR023246 | |
| PRINTS | PR02044 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0021702 |
cerebellar Purkinje cell differentiation |
ECO:0000314 |
P |
As seen in figure 5b, expression of AUTS2 protein in Purkinje cells is identified by staining with calbindin immunofluorescence. |
complete | |||||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0015629 |
actin cytoskeleton |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097484 |
dendrite extension |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048675 |
axon extension |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035022 |
positive regulation of Rac protein signal transduction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031532 |
actin cytoskeleton reorganization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010592 |
positive regulation of lamellipodium assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001764 |
neuron migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005575 |
cellular_component |
ECO:0000307 |
no biological data found used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000620 |
positive regulation of histone H4-K16 acetylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051571 |
positive regulation of histone H3-K4 methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030426 |
growth cone |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Bedogni, F et al. (2010) Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology. Gene Expr. Patterns 10 9-15 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gao, Z et al. (2014) An AUTS2-Polycomb complex activates gene expression in the CNS. Nature 516 349-54 PubMed GONUTS page
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