GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:ASXL3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ASXL3 (synonyms: KIAA1713) | |
| Protein Name(s) | Putative Polycomb group protein ASXL3
Additional sex combs-like protein 3 | |
| External Links | ||
| UniProt | Q9C0F0 | |
| EMBL | AC023192 AC090989 AC010798 AK056450 AK131454 AB051500 AL133050 | |
| CCDS | CCDS45847.1 | |
| PIR | T42653 | |
| RefSeq | NP_085135.1 | |
| UniGene | Hs.464876 | |
| ProteinModelPortal | Q9C0F0 | |
| STRING | 9606.ENSP00000269197 | |
| iPTMnet | Q9C0F0 | |
| BioMuta | ASXL3 | |
| DMDM | 172046234 | |
| PaxDb | Q9C0F0 | |
| PRIDE | Q9C0F0 | |
| Ensembl | ENST00000269197 | |
| GeneID | 80816 | |
| KEGG | hsa:80816 | |
| UCSC | uc002kxq.2 | |
| CTD | 80816 | |
| GeneCards | ASXL3 | |
| HGNC | HGNC:29357 | |
| HPA | HPA039539 HPA040034 | |
| MalaCards | ASXL3 | |
| MIM | 615115 615485 | |
| neXtProt | NX_Q9C0F0 | |
| Orphanet | 352577 | |
| PharmGKB | PA162377010 | |
| eggNOG | ENOG410IIF3 ENOG4111F3G | |
| GeneTree | ENSGT00520000055578 | |
| HOGENOM | HOG000034113 | |
| HOVERGEN | HBG100451 | |
| InParanoid | Q9C0F0 | |
| KO | K11471 | |
| OMA | GICSNIK | |
| OrthoDB | EOG7SXW2P | |
| PhylomeDB | Q9C0F0 | |
| TreeFam | TF328464 | |
| GenomeRNAi | 80816 | |
| NextBio | 71202 | |
| PRO | PR:Q9C0F0 | |
| Proteomes | UP000005640 | |
| Bgee | Q9C0F0 | |
| CleanEx | HS_ASXL3 | |
| ExpressionAtlas | Q9C0F0 | |
| Genevisible | Q9C0F0 | |
| GO | GO:0005634 GO:0003677 GO:0046872 GO:0006355 GO:0006351 | |
| InterPro | IPR026905 IPR024811 IPR028020 IPR024818 IPR007759 | |
| PANTHER | PTHR13578 PTHR13578:SF18 | |
| Pfam | PF13919 PF05066 PF13922 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0051055 |
negative regulation of lipid biosynthetic process |
ECO:0000314 |
P |
As shown in Fig. 4E, ASXL3 overexpression reduced intracellular lipid deposition. This data suggests that ASXL3 negatively regulates lipogenesis by repressing the transcriptional activity of LXRα, a key mediator of lipogenesis in the liver. |
complete | |||||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2684063 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042975 |
peroxisome proliferator activated receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2684063 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035517 |
PR-DUB complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0261823 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009887 |
animal organ morphogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2684063 |
P |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0261823 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0261823 |
F |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0000790 |
nuclear chromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1922552 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006351 |
transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Shin, N et al. (2014) Repression of LXRα by a novel member of additional sex comb-like family, ASXL3. Biochem. Biophys. Res. Commun. 454 479-485 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
