HUMAN:ASPM

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ASPM (synonyms: MCPH5)
Protein Name(s)	Abnormal spindle-like microcephaly-associated protein Abnormal spindle protein homolog Asp homolog
External Links
UniProt	Q8IZT6
EMBL	AF509326 AY099890 AY099891 AY099892 AY099893 AY101201 AY367065 AY971956 AL353809 CH471067 BC015396 BC034607 AK001411
CCDS	CCDS1389.1 CCDS55672.1
RefSeq	NP_001193775.1 NP_060606.3
UniGene	Hs.121028
ProteinModelPortal	Q8IZT6
SMR	Q8IZT6
BioGrid	129236
IntAct	Q8IZT6
MINT	MINT-3038606
STRING	9606.ENSP00000356379
iPTMnet	Q8IZT6
PhosphoSitePlus	Q8IZT6
BioMuta	ASPM
DMDM	215273935
EPD	Q8IZT6
MaxQB	Q8IZT6
PaxDb	Q8IZT6
PeptideAtlas	Q8IZT6
PRIDE	Q8IZT6
Ensembl	ENST00000294732 ENST00000367409
GeneID	259266
KEGG	hsa:259266
UCSC	uc001gtu.4
CTD	259266
DisGeNET	259266
GeneCards	ASPM
GeneReviews	ASPM
HGNC	HGNC:19048
HPA	CAB017816
MalaCards	ASPM
MIM	605481 608716
neXtProt	NX_Q8IZT6
OpenTargets	ENSG00000066279
Orphanet	2512
PharmGKB	PA38782
eggNOG	KOG0165 ENOG410XSAR
GeneTree	ENSGT00560000077332
HOGENOM	HOG000034105
HOVERGEN	HBG050595
InParanoid	Q8IZT6
KO	K16743
OMA	QSHFRRW
OrthoDB	EOG091G0332
PhylomeDB	Q8IZT6
TreeFam	TF351180
ChiTaRS	ASPM
GeneWiki	ASPM_(gene)
GenomeRNAi	259266
PRO	PR:Q8IZT6
Proteomes	UP000005640
Bgee	ENSG00000066279
ExpressionAtlas	Q8IZT6
Genevisible	Q8IZT6
GO	GO:0005737 GO:0072687 GO:0036449 GO:0030496 GO:0097431 GO:0005634 GO:0021987 GO:0048589 GO:0021873 GO:0051661 GO:0008584 GO:0007067 GO:0045769 GO:0045665 GO:0001764 GO:0097150 GO:0048477 GO:0090263 GO:0002052 GO:0051445 GO:0007283 GO:0090306 GO:0051653 GO:0007051
Gene3D	1.10.418.10 2.60.40.10 4.10.270.10
InterPro	IPR016024 IPR031549 IPR029955 IPR001715 IPR013783 IPR000048 IPR027401 IPR027417
PANTHER	PTHR11915:SF391
Pfam	PF15780 PF00307 PF00612
SMART	SM00033 SM00015
SUPFAM	SSF47576 SSF48371 SSF52540
PROSITE	PS50021 PS50096

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001764	neuron migration	PMID:27920410^[1]	ECO:0000314			P		Provides regulation during the process of neurogenesis and mitotic spindle regulation.	complete CACAO 12854
part_of	GO:0097431	mitotic spindle pole	PMID:15972725^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036449	microtubule minus-end	PMID:21044324^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0051233)	Seeded From UniProt	complete
involved_in	GO:0051653	spindle localization	PMID:21044324^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007051	spindle organization	PMID:21044324^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	PMID:21044324^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21044324^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0051329)	Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZQ1 ensembl:ENSRNOP00000016797	C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZQ1 ensembl:ENSRNOP00000016797	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZQ1 ensembl:ENSRNOP00000016797	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZQ1 ensembl:ENSRNOP00000016797	C		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	C		Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0090306	spindle assembly involved in meiosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
part_of	GO:0072687	meiotic spindle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	C		Seeded From UniProt	complete
involved_in	GO:0051661	maintenance of centrosome location	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0051445	regulation of meiotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0045769	negative regulation of asymmetric cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	C		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0021873	forebrain neuroblast division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	F		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	P		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CJ27 ensembl:ENSMUSP00000059159	C		Seeded From UniProt	complete
involved_in	GO:0007051	spindle organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029955	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hashmi, JA et al. () A novel splice-site mutation in the ASPM gene underlies autosomal recessive primary microcephaly. Ann Saudi Med 36 391-396 PubMed GONUTS page
↑ Kouprina, N et al. (2005) The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein. Hum. Mol. Genet. 14 2155-65 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Higgins, J et al. (2010) Human ASPM participates in spindle organisation, spindle orientation and cytokinesis. BMC Cell Biol. 11 85 PubMed GONUTS page

[PMID:27920410-1] Hashmi, JA et al. () A novel splice-site mutation in the ASPM gene underlies autosomal recessive primary microcephaly. Ann Saudi Med 36 391-396 PubMed GONUTS page

[PMID:15972725-2] Kouprina, N et al. (2005) The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein. Hum. Mol. Genet. 14 2155-65 PubMed GONUTS page

[PMID:21044324-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Higgins, J et al. (2010) Human ASPM participates in spindle organisation, spindle orientation and cytokinesis. BMC Cell Biol. 11 85 PubMed GONUTS page

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HUMAN:ASPM

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