GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:ASCL4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ASCL4 (synonyms: BHLHA44, HASH4) | |
| Protein Name(s) | Achaete-scute homolog 4
ASH-4 hASH4 Achaete-scute-like protein 4 Class A basic helix-loop-helix protein 44 bHLHa44 | |
| External Links | ||
| UniProt | Q6XD76 | |
| EMBL | AY238895 AC007622 BC128211 BC128212 BK000275 | |
| RefSeq | NP_982260.2 | |
| UniGene | Hs.149910 | |
| ProteinModelPortal | Q6XD76 | |
| SMR | Q6XD76 | |
| BioGrid | 125737 | |
| STRING | 9606.ENSP00000345420 | |
| PhosphoSite | Q6XD76 | |
| DMDM | 74749505 | |
| PaxDb | Q6XD76 | |
| PRIDE | Q6XD76 | |
| Ensembl | ENST00000342331 | |
| GeneID | 121549 | |
| KEGG | hsa:121549 | |
| UCSC | uc001tmr.3 | |
| CTD | 121549 | |
| GeneCards | GC12P108168 | |
| HGNC | HGNC:24311 | |
| HPA | HPA036116 | |
| MIM | 609155 | |
| neXtProt | NX_Q6XD76 | |
| PharmGKB | PA134869300 | |
| eggNOG | NOG309992 | |
| HOGENOM | HOG000034089 | |
| InParanoid | Q6XD76 | |
| KO | K09067 | |
| OMA | RRAECNS | |
| OrthoDB | EOG7B5WZK | |
| PhylomeDB | Q6XD76 | |
| TreeFam | TF322889 | |
| GenomeRNAi | 121549 | |
| NextBio | 80770 | |
| PRO | PR:Q6XD76 | |
| Proteomes | UP000005640 | |
| Bgee | Q6XD76 | |
| CleanEx | HS_ASCL4 | |
| Genevestigator | Q6XD76 | |
| GO | GO:0005634 GO:0003677 GO:0006357 GO:0043588 GO:0006351 | |
| Gene3D | 4.10.280.10 | |
| InterPro | IPR015660 IPR011598 | |
| PANTHER | PTHR13935 | |
| Pfam | PF00010 | |
| SMART | SM00353 | |
| SUPFAM | SSF47459 | |
| PROSITE | PS50888 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0043588 |
skin development |
ECO:0000314 |
P |
Figure 2 has real-time PCR results that show a 7x increase in Hash4 activity in fetal skin compared to adult skin, indicting an involvement in skin development. |
complete | |||||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043588 |
skin development |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005575 |
cellular_component |
ECO:0000307 |
no biological data found used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0090575 |
RNA polymerase II transcription factor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000358347 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000137 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004170 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1928820 |
P |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0002561 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000137 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046983 |
protein dimerization activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Jonsson, M et al. (2004) Hash4, a novel human achaete-scute homologue found in fetal skin. Genomics 84 859-66 PubMed GONUTS page
- ↑ 2.0 2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
d
p
r
