HUMAN:ARRB2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ARRB2 (synonyms: ARB2, ARR2)
Protein Name(s)	Beta-arrestin-2 Arrestin beta-2
External Links
UniProt	P32121
EMBL	Z11501 AF106941 DQ664180 EU883572 AK097542 AK297181 CR450310 DQ314866 AC091153 CH471108 CH471108 BC007427 BC067368
CCDS	CCDS11050.1 CCDS11051.1 CCDS58504.1 CCDS58505.1
PIR	S18984
RefSeq	NP_001244257.1 NP_001244258.1 NP_001244259.1 NP_001244260.1 NP_004304.1 NP_945355.1
UniGene	Hs.435811
ProteinModelPortal	P32121
SMR	P32121
BioGrid	106902
DIP	DIP-40089N
IntAct	P32121
MINT	MINT-216692
STRING	9606.ENSP00000269260
PhosphoSite	P32121
DMDM	20141230
MaxQB	P32121
PaxDb	P32121
PRIDE	P32121
DNASU	409
Ensembl	ENST00000269260 ENST00000346341 ENST00000381488 ENST00000412477
GeneID	409
KEGG	hsa:409
UCSC	uc002fyj.3 uc002fyl.3 uc002fym.3
CTD	409
GeneCards	GC17P004613
HGNC	HGNC:712
MIM	107941
neXtProt	NX_P32121
PharmGKB	PA60
eggNOG	NOG302111
GeneTree	ENSGT00390000013152
HOVERGEN	HBG002399
InParanoid	P32121
KO	K04439
OMA	KPHDHIT
OrthoDB	EOG79W954
PhylomeDB	P32121
TreeFam	TF314260
Reactome	REACT_118614 REACT_172599 REACT_21384
SignaLink	P32121
ChiTaRS	ARRB2
GeneWiki	Arrestin_beta_2
GenomeRNAi	409
NextBio	1719
PRO	PR:P32121
Proteomes	UP000005640
Bgee	P32121
CleanEx	HS_ARRB2
ExpressionAtlas	P32121
Genevestigator	P32121
GO	GO:0016323 GO:0005905 GO:0005737 GO:0031410 GO:0005829 GO:0043197 GO:0030139 GO:0005634 GO:0005886 GO:0014069 GO:0045211 GO:0031701 GO:0019899 GO:0001664 GO:0032947 GO:0005102 GO:0031625 GO:0007628 GO:0007596 GO:0007420 GO:0060326 GO:0002032 GO:0050965 GO:0042699 GO:0002031 GO:0043154 GO:0034260 GO:0032691 GO:0032695 GO:0032715 GO:0045953 GO:0032088 GO:0031397 GO:0090201 GO:0034392 GO:0034122 GO:0032720 GO:0007219 GO:0030168 GO:0051928 GO:2000573 GO:0070374 GO:0033138 GO:0050731 GO:0051897 GO:0031398 GO:0002092 GO:0032226 GO:0043161 GO:0015031 GO:0016567 GO:0031623 GO:0060765 GO:0006366 GO:0007179
Gene3D	2.60.40.640 2.60.40.840
InterPro	IPR000698 IPR011021 IPR014752 IPR011022 IPR017864 IPR014753 IPR014756
PANTHER	PTHR11792
Pfam	PF02752 PF00339
PRINTS	PR00309
SMART	SM01017
SUPFAM	SSF81296
PROSITE	PS00295

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:21711983^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23382074^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
involved_in	GO:0060765	regulation of androgen receptor signaling pathway	PMID:19372219^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	PMID:19372219^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:19372219^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23804	F		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:12958365^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:12958365^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:19372219^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q91YI4	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:12958365^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0031398	positive regulation of protein ubiquitination	PMID:11588219^[5]	ECO:0000314			P		Figure 3	complete
part_of	GO:0005737	cytoplasm	PMID:12958365^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:21711983^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0007212)	Seeded From UniProt	complete
involved_in	GO:0007212	dopamine receptor signaling pathway	PMID:21711983^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0099565)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:12582207^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:10644702^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:15635042^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	PMID:18604210^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:15878855^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:16378096^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:15125834^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031701	angiotensin receptor binding	PMID:15611106^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P30556	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:15878855^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:15611106^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:16378096^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	PMID:23341447^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:15878855^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:16820410^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18604210^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23341447^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16820410^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15611106^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16325578^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16820410^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:18604210^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99706	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:18604210^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P43628	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:18604210^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P43626	F		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:22457824^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	PMID:12582207^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	PMID:12582207^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	PMID:10644702^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	PMID:10644702^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P61073	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:1990763	arrestin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:1904037	positive regulation of epithelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:0042699	follicle-stimulating hormone signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0034392	negative regulation of smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:0031859	platelet activating factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031826	type 2A serotonin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031762	follicle-stimulating hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031702	type 1 angiotensin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031692	alpha-1B adrenergic receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
enables	GO:0031691	alpha-1A adrenergic receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	F		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	C		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29067 ensembl:ENSRNOP00000026207	P		Seeded From UniProt	complete
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	F		Seeded From UniProt	complete
involved_in	GO:0034122	negative regulation of toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0032695	negative regulation of interleukin-12 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0032226	positive regulation of synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000698 InterPro:IPR014753	P		Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	PMID:24157794^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_direct_input:(UniProtKB:P08908)\|has_direct_input:(UniProtKB:P11362)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21149639^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Reactome:R-HSA-4086400	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-8868230 Reactome:R-HSA-8868072 Reactome:R-HSA-8868071 Reactome:R-HSA-8867756 Reactome:R-HSA-8867754 Reactome:R-HSA-8866283 Reactome:R-HSA-8866269 Reactome:R-HSA-8852167 Reactome:R-HSA-5696945 Reactome:R-HSA-5138459 Reactome:R-HSA-5138433 Reactome:R-HSA-418200 Reactome:R-HSA-418176 Reactome:R-HSA-418172	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Beaulieu, JM (2012) A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci 37 7-16 PubMed GONUTS page
↑ Armour, SM et al. (2013) A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol. Cell. Biol. 33 1487-502 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Li, X et al. (2009) Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J. Biol. Chem. 284 16170-82 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Chen, W et al. (2003) Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science 301 1394-7 PubMed GONUTS page
↑ Shenoy, SK et al. (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294 1307-13 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Ahn, S et al. (2003) Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proc. Natl. Acad. Sci. U.S.A. 100 1740-4 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Cheng, ZJ et al. (2000) beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J. Biol. Chem. 275 2479-85 PubMed GONUTS page
↑ Hunton, DL et al. (2005) Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Mol. Pharmacol. 67 1229-36 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Yu, MC et al. (2008) An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat. Immunol. 9 898-907 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Girnita, L et al. (2005) {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J. Biol. Chem. 280 24412-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page
↑ Gao, H et al. (2004) Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. Mol. Cell 14 303-17 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Barnes, WG et al. (2005) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J. Biol. Chem. 280 8041-50 PubMed GONUTS page
↑ ^14.0 ^14.1 Watts, AO et al. (2013) β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. J. Biol. Chem. 288 7169-81 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Neuhaus, EM et al. (2006) Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. J. Cell. Sci. 119 3047-56 PubMed GONUTS page
↑ Kang, J et al. (2005) A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123 833-47 PubMed GONUTS page
↑ Canals, M et al. (2012) Ubiquitination of CXCR7 controls receptor trafficking. PLoS ONE 7 e34192 PubMed GONUTS page
↑ Borroto-Escuela, DO et al. (2013) Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2. Biochem. Biophys. Res. Commun. 441 387-92 PubMed GONUTS page
↑ Sandén, C et al. (2011) G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments. Mol. Pharmacol. 79 400-10 PubMed GONUTS page

[PMID:21711983-1] 1.0 ^1.1 ^1.2 Beaulieu, JM (2012) A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci 37 7-16 PubMed GONUTS page

[PMID:23382074-2] Armour, SM et al. (2013) A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol. Cell. Biol. 33 1487-502 PubMed GONUTS page

[PMID:19372219-3] 3.0 ^3.1 ^3.2 ^3.3 Li, X et al. (2009) Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J. Biol. Chem. 284 16170-82 PubMed GONUTS page

[PMID:12958365-4] 4.0 ^4.1 ^4.2 ^4.3 Chen, W et al. (2003) Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science 301 1394-7 PubMed GONUTS page

[PMID:11588219-5] Shenoy, SK et al. (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294 1307-13 PubMed GONUTS page

[PMID:12582207-6] 6.0 ^6.1 ^6.2 Ahn, S et al. (2003) Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proc. Natl. Acad. Sci. U.S.A. 100 1740-4 PubMed GONUTS page

[PMID:10644702-7] 7.0 ^7.1 ^7.2 Cheng, ZJ et al. (2000) beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J. Biol. Chem. 275 2479-85 PubMed GONUTS page

[PMID:15635042-8] Hunton, DL et al. (2005) Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Mol. Pharmacol. 67 1229-36 PubMed GONUTS page

[PMID:18604210-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Yu, MC et al. (2008) An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat. Immunol. 9 898-907 PubMed GONUTS page

[PMID:15878855-10] 10.0 ^10.1 ^10.2 Girnita, L et al. (2005) {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J. Biol. Chem. 280 24412-9 PubMed GONUTS page

[PMID:16378096-11] 11.0 ^11.1 Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page

[PMID:15125834-12] Gao, H et al. (2004) Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. Mol. Cell 14 303-17 PubMed GONUTS page

[PMID:15611106-13] 13.0 ^13.1 ^13.2 Barnes, WG et al. (2005) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J. Biol. Chem. 280 8041-50 PubMed GONUTS page

[PMID:23341447-14] 14.0 ^14.1 Watts, AO et al. (2013) β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. J. Biol. Chem. 288 7169-81 PubMed GONUTS page

[PMID:16820410-15] 15.0 ^15.1 ^15.2 Neuhaus, EM et al. (2006) Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. J. Cell. Sci. 119 3047-56 PubMed GONUTS page

[PMID:16325578-16] Kang, J et al. (2005) A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123 833-47 PubMed GONUTS page

[PMID:22457824-17] Canals, M et al. (2012) Ubiquitination of CXCR7 controls receptor trafficking. PLoS ONE 7 e34192 PubMed GONUTS page

[PMID:24157794-18] Borroto-Escuela, DO et al. (2013) Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2. Biochem. Biophys. Res. Commun. 441 387-92 PubMed GONUTS page

[PMID:21149639-19] Sandén, C et al. (2011) G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments. Mol. Pharmacol. 79 400-10 PubMed GONUTS page

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HUMAN:ARRB2

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