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HUMAN:ARFP1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ARFIP1 | |
| Protein Name(s) | Arfaptin-1
ADP-ribosylation factor-interacting protein 1 | |
| External Links | ||
| UniProt | P53367 | |
| EMBL | U52521 AF124489 AK290472 AK299600 AC099339 AC106882 AC113155 CH471056 CH471056 BC103759 BC105114 BC105116 BC143675 | |
| CCDS | CCDS34080.1 CCDS3780.1 | |
| PIR | G02515 | |
| RefSeq | NP_001020764.1 NP_001020766.1 NP_001274360.1 NP_001274361.1 NP_001274362.1 NP_055262.1 XP_011530171.1 XP_011530172.1 | |
| UniGene | Hs.416089 | |
| ProteinModelPortal | P53367 | |
| SMR | P53367 | |
| BioGrid | 118084 | |
| IntAct | P53367 | |
| MINT | MINT-3019815 | |
| STRING | 9606.ENSP00000296557 | |
| iPTMnet | P53367 | |
| PhosphoSitePlus | P53367 | |
| DMDM | 21264399 | |
| EPD | P53367 | |
| MaxQB | P53367 | |
| PaxDb | P53367 | |
| PeptideAtlas | P53367 | |
| PRIDE | P53367 | |
| Ensembl | ENST00000353617 ENST00000356064 ENST00000405727 ENST00000429148 ENST00000451320 | |
| GeneID | 27236 | |
| KEGG | hsa:27236 | |
| UCSC | uc003imz.5 uc011cij.4 | |
| CTD | 27236 | |
| DisGeNET | 27236 | |
| GeneCards | ARFIP1 | |
| HGNC | HGNC:21496 | |
| HPA | CAB005080 HPA037375 HPA063759 | |
| MIM | 605928 | |
| neXtProt | NX_P53367 | |
| OpenTargets | ENSG00000164144 | |
| PharmGKB | PA134920621 | |
| eggNOG | KOG3876 ENOG410YJUM | |
| GeneTree | ENSGT00500000044828 | |
| HOGENOM | HOG000236308 | |
| HOVERGEN | HBG050564 | |
| InParanoid | P53367 | |
| KO | K20314 | |
| OMA | FQVHKEK | |
| OrthoDB | EOG091G0H30 | |
| PhylomeDB | P53367 | |
| TreeFam | TF314945 | |
| SIGNOR | P53367 | |
| ChiTaRS | ARFIP1 | |
| GeneWiki | ARFIP1 | |
| GenomeRNAi | 27236 | |
| PRO | PR:P53367 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000164144 | |
| CleanEx | HS_ARFIP1 | |
| ExpressionAtlas | P53367 | |
| Genevisible | P53367 | |
| GO | GO:0005829 GO:0000139 GO:0032588 GO:0045296 GO:0070273 GO:0006886 GO:0034315 GO:0050708 | |
| Gene3D | 1.20.1270.60 | |
| InterPro | IPR027267 IPR010504 IPR030793 IPR030798 | |
| PANTHER | PTHR12141 PTHR12141:SF9 | |
| Pfam | PF06456 | |
| SMART | SM01015 | |
| PROSITE | PS50870 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:1905280 |
negative regulation of retrograde transport, endosome to Golgi |
ECO:0000315 |
P |
Organism: Homo sapiens Protein: Arfaptin-1//Arfaptin-1 Figure 2 shows the effects of overexpression of Arfaptin-1 on STxB retrograde transport from the endosome to the Golgi |
complete | |||||
|
part_of |
GO:0000139 |
Golgi membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032588 |
trans-Golgi network membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000951698 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006886 |
intracellular protein transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000254123 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:894645 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005543 |
phospholipid binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0037884 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050708 |
regulation of protein secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006886 |
intracellular protein transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000139 |
Golgi membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032588 |
trans-Golgi network membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000139 |
Golgi membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032588 |
trans-Golgi network membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050708 |
regulation of protein secretion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Huang, LH et al. (2015) Arfaptin-1 negatively regulates Arl1-mediated retrograde transport. PLoS ONE 10 e0118743 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kanoh, H et al. (1997) Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes. J. Biol. Chem. 272 5421-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 Ho, WT et al. (2003) Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells. FEBS Lett. 537 91-5 PubMed GONUTS page
- ↑ 5.0 5.1 Cruz-Garcia, D et al. (2013) Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export. EMBO J. 32 1717-29 PubMed GONUTS page
