HUMAN:ARBK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ADRBK1 (synonyms: BARK, BARK1, GRK2)
Protein Name(s)	Beta-adrenergic receptor kinase 1 Beta-ARK-1 G-protein coupled receptor kinase 2
External Links
UniProt	P25098
EMBL	X61157 M80776 U08438 U08435 U08436 U08437 EU326303 BC037963 BC090863
CCDS	CCDS8156.1
PIR	A53791
RefSeq	NP_001610.2
UniGene	Hs.83636
PDB	1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK
PDBsum	1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK
ProteinModelPortal	P25098
SMR	P25098
BioGrid	106665
DIP	DIP-42429N
IntAct	P25098
MINT	MINT-1214643
STRING	9606.ENSP00000312262
BindingDB	P25098
ChEMBL	CHEMBL4079
DrugBank	DB00171
GuidetoPHARMACOLOGY	1466
PhosphoSite	P25098
DMDM	126302521
MaxQB	P25098
PaxDb	P25098
PRIDE	P25098
DNASU	156
Ensembl	ENST00000308595
GeneID	156
KEGG	hsa:156
UCSC	uc009yrn.1
CTD	156
GeneCards	GC11P067033
HGNC	HGNC:289
HPA	CAB005021 CAB037248 HPA048330
MIM	109635
neXtProt	NX_P25098
PharmGKB	PA40
eggNOG	COG0515
GeneTree	ENSGT00770000120493
HOGENOM	HOG000006742
HOVERGEN	HBG050559
InParanoid	P25098
KO	K00910
OMA	DFCLKHL
OrthoDB	EOG7FV3PP
PhylomeDB	P25098
TreeFam	TF313940
BRENDA	2.7.11.15
Reactome	REACT_18283 REACT_9000
SignaLink	P25098
ChiTaRS	ADRBK1
EvolutionaryTrace	P25098
GeneWiki	Beta_adrenergic_receptor_kinase
GenomeRNAi	156
NextBio	621
PRO	PR:P25098
Proteomes	UP000005640
Bgee	P25098
CleanEx	HS_ADRBK1
ExpressionAtlas	P25098
Genevestigator	P25098
GO	GO:0005737 GO:0005829 GO:0016020 GO:0005886 GO:0031694 GO:0005524 GO:0047696 GO:0031755 GO:0004703 GO:0004672 GO:0007202 GO:0060048 GO:0002029 GO:0007173 GO:0008543 GO:0007213 GO:0007507 GO:0045087 GO:0045988 GO:0003108 GO:0048011 GO:0018105 GO:0018107 GO:0033605 GO:0031623 GO:0007165 GO:0007217 GO:0038032
Gene3D	2.30.29.30
InterPro	IPR000961 IPR000239 IPR011009 IPR001849 IPR011993 IPR000719 IPR017441 IPR016137 IPR002290 IPR008271
Pfam	PF00169 PF00069 PF00615
PRINTS	PR00717
SMART	SM00233 SM00315 SM00133 SM00220
SUPFAM	SSF48097 SSF56112
PROSITE	PS51285 PS50003 PS00107 PS50011 PS00108 PS50132

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0046718	viral entry into host cell	PMID:23029581^[1]	ECO:0000315			P	Figure 5 says "GRK2 plays a role in YFV-17D entry"	complete CACAO 5261
	GO:0019079	viral genome replication	PMID:23029581^[1]	ECO:0000315			P	Figure 6 says "GRK2 plays a role in viral RNA synthesis."	complete CACAO 5262
involved_in	GO:0019079	viral genome replication	PMID:23029581^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	PMID:23029581^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:15051637^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045988	negative regulation of striated muscle contraction	PMID:15051637^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033605	positive regulation of catecholamine secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26817	P	Seeded From UniProt	complete
enables	GO:0031694	alpha-2A adrenergic receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21146	F	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21146	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21146	C	Seeded From UniProt	complete
involved_in	GO:0007217	tachykinin receptor signaling pathway	PMID:17986524^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21146	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17986524^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004703	G protein-coupled receptor kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21146	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21146	F	Seeded From UniProt	complete
involved_in	GO:0003108	negative regulation of the force of heart contraction by chemical signal	PMID:15051637^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21146	P	Seeded From UniProt	complete
enables	GO:0031755	Edg-2 lysophosphatidic acid receptor binding	PMID:19306925^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:20074556^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	P	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	C	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	P	Seeded From UniProt	complete
enables	GO:0004703	G protein-coupled receptor kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	F	Seeded From UniProt	complete
involved_in	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	P	Seeded From UniProt	complete
involved_in	GO:0002026	regulation of the force of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99MK8 ensembl:ENSMUSP00000086114	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961	F	Seeded From UniProt	complete
enables	GO:0004703	G protein-coupled receptor kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000239	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000239 InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000239 InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000239	P	Seeded From UniProt	complete
enables	GO:0047696	beta-adrenergic receptor kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.15	F	Seeded From UniProt	complete
enables	GO:0047696	beta-adrenergic receptor kinase activity	Reactome:R-HSA-8851797	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	Reactome:R-HSA-5633040	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8982645 Reactome:R-HSA-8982641 Reactome:R-HSA-8851797 Reactome:R-HSA-416516 Reactome:R-HSA-111970 Reactome:R-HSA-111966	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8866268 Reactome:R-HSA-111970	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Le Sommer, C et al. (2012) G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication. PLoS Negl Trop Dis 6 e1820 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Williams, ML et al. (2004) Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. Circulation 109 1590-3 PubMed GONUTS page
↑ ^4.0 ^4.1 Jorgensen, R et al. (2008) Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer. Mol. Pharmacol. 73 349-58 PubMed GONUTS page
↑ Aziziyeh, AI et al. (2009) Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. Cell. Signal. 21 1207-17 PubMed GONUTS page
↑ Kuwasako, K et al. (2010) Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. Biochem. Biophys. Res. Commun. 392 380-5 PubMed GONUTS page

[PMID:23029581-1] 1.0 ^1.1 ^1.2 ^1.3 Le Sommer, C et al. (2012) G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication. PLoS Negl Trop Dis 6 e1820 PubMed GONUTS page

[PMID:19946888-2] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:15051637-3] 3.0 ^3.1 ^3.2 Williams, ML et al. (2004) Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. Circulation 109 1590-3 PubMed GONUTS page

[PMID:17986524-4] 4.0 ^4.1 Jorgensen, R et al. (2008) Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer. Mol. Pharmacol. 73 349-58 PubMed GONUTS page

[PMID:19306925-5] Aziziyeh, AI et al. (2009) Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. Cell. Signal. 21 1207-17 PubMed GONUTS page

[PMID:20074556-6] Kuwasako, K et al. (2010) Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. Biochem. Biophys. Res. Commun. 392 380-5 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

HUMAN:ARBK1

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

k

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools