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HUMAN:APLP1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | APLP1 | |
| Protein Name(s) | Amyloid-like protein 1
APLP APLP-1 C30 | |
| External Links | ||
| UniProt | P51693 | |
| EMBL | U48437 AD000864 BC012889 BC013850 | |
| CCDS | CCDS32997.1 | |
| RefSeq | NP_001019978.1 NP_005157.1 | |
| UniGene | Hs.74565 | |
| PDB | 3PMR 3Q7G 3Q7L 3QMK | |
| PDBsum | 3PMR 3Q7G 3Q7L 3QMK | |
| ProteinModelPortal | P51693 | |
| SMR | P51693 | |
| BioGrid | 106830 | |
| DIP | DIP-30846N | |
| IntAct | P51693 | |
| MINT | MINT-1395075 | |
| STRING | 9606.ENSP00000221891 | |
| PhosphoSite | P51693 | |
| DMDM | 28558769 | |
| PaxDb | P51693 | |
| PRIDE | P51693 | |
| DNASU | 333 | |
| Ensembl | ENST00000221891 | |
| GeneID | 333 | |
| KEGG | hsa:333 | |
| UCSC | uc002oce.3 uc002ocf.3 | |
| CTD | 333 | |
| GeneCards | GC19P036359 | |
| HGNC | HGNC:597 | |
| HPA | HPA028971 | |
| MIM | 104775 | |
| neXtProt | NX_P51693 | |
| PharmGKB | PA24884 | |
| eggNOG | NOG289770 | |
| GeneTree | ENSGT00530000063252 | |
| HOGENOM | HOG000232190 | |
| HOVERGEN | HBG000051 | |
| InParanoid | P51693 | |
| KO | K05639 | |
| OMA | CGSDRFR | |
| PhylomeDB | P51693 | |
| TreeFam | TF317274 | |
| ChiTaRS | APLP1 | |
| EvolutionaryTrace | P51693 | |
| GeneWiki | APLP1 | |
| GenomeRNAi | 333 | |
| NextBio | 1377 | |
| PRO | PR:P51693 | |
| Proteomes | UP000005640 | |
| Bgee | P51693 | |
| CleanEx | HS_APLP1 | |
| ExpressionAtlas | P51693 | |
| Genevestigator | P51693 | |
| GO | GO:0005604 GO:0005794 GO:0016021 GO:0048471 GO:0005886 GO:0031694 GO:0031695 GO:0031696 GO:0008201 GO:0042802 GO:0046914 GO:0007193 GO:0006915 GO:0007155 GO:0071874 GO:0006897 GO:0030198 GO:0030900 GO:0006378 GO:0030818 GO:0007399 GO:0009887 GO:0006417 | |
| Gene3D | 3.30.1490.140 3.90.570.10 | |
| InterPro | IPR008155 IPR011178 IPR024329 IPR008154 IPR019744 IPR015849 IPR019745 IPR019543 | |
| Pfam | PF10515 PF12924 PF12925 PF02177 | |
| PRINTS | PR00203 | |
| SMART | SM00006 | |
| SUPFAM | SSF109843 SSF56491 SSF89811 | |
| PROSITE | PS00319 PS00320 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0071874 |
cellular response to norepinephrine stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031696 |
alpha-2C adrenergic receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031695 |
alpha-2B adrenergic receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031694 |
alpha-2A adrenergic receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0106072 |
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008201 |
heparin binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046914 |
transition metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009887 |
animal organ morphogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008201 |
heparin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Weber, B et al. (2006) Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase. Cell. Signal. 18 1748-57 PubMed GONUTS page
- ↑ Xue, Y et al. (2011) Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization. Proc. Natl. Acad. Sci. U.S.A. 108 16229-34 PubMed GONUTS page
- ↑ Soba, P et al. (2005) Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J. 24 3624-34 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Lenkkeri, U et al. (1998) Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1. Hum. Genet. 102 192-6 PubMed GONUTS page
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