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HUMAN:APLP1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) APLP1
Protein Name(s) Amyloid-like protein 1

APLP APLP-1 C30

External Links
UniProt P51693
EMBL U48437
AD000864
BC012889
BC013850
CCDS CCDS32997.1
RefSeq NP_001019978.1
NP_005157.1
UniGene Hs.74565
PDB 3PMR
3Q7G
3Q7L
3QMK
PDBsum 3PMR
3Q7G
3Q7L
3QMK
ProteinModelPortal P51693
SMR P51693
BioGrid 106830
DIP DIP-30846N
IntAct P51693
MINT MINT-1395075
STRING 9606.ENSP00000221891
PhosphoSite P51693
DMDM 28558769
PaxDb P51693
PRIDE P51693
DNASU 333
Ensembl ENST00000221891
GeneID 333
KEGG hsa:333
UCSC uc002oce.3
uc002ocf.3
CTD 333
GeneCards GC19P036359
HGNC HGNC:597
HPA HPA028971
MIM 104775
neXtProt NX_P51693
PharmGKB PA24884
eggNOG NOG289770
GeneTree ENSGT00530000063252
HOGENOM HOG000232190
HOVERGEN HBG000051
InParanoid P51693
KO K05639
OMA CGSDRFR
PhylomeDB P51693
TreeFam TF317274
ChiTaRS APLP1
EvolutionaryTrace P51693
GeneWiki APLP1
GenomeRNAi 333
NextBio 1377
PRO PR:P51693
Proteomes UP000005640
Bgee P51693
CleanEx HS_APLP1
ExpressionAtlas P51693
Genevestigator P51693
GO GO:0005604
GO:0005794
GO:0016021
GO:0048471
GO:0005886
GO:0031694
GO:0031695
GO:0031696
GO:0008201
GO:0042802
GO:0046914
GO:0007193
GO:0006915
GO:0007155
GO:0071874
GO:0006897
GO:0030198
GO:0030900
GO:0006378
GO:0030818
GO:0007399
GO:0009887
GO:0006417
Gene3D 3.30.1490.140
3.90.570.10
InterPro IPR008155
IPR011178
IPR024329
IPR008154
IPR019744
IPR015849
IPR019745
IPR019543
Pfam PF10515
PF12924
PF12925
PF02177
PRINTS PR00203
SMART SM00006
SUPFAM SSF109843
SSF56491
SSF89811
PROSITE PS00319
PS00320

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071874

cellular response to norepinephrine stimulus

PMID:16531006[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:16531006[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0031696

alpha-2C adrenergic receptor binding

PMID:16531006[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P18825

F

Seeded From UniProt

complete

enables

GO:0031695

alpha-2B adrenergic receptor binding

PMID:16531006[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P18089

F

Seeded From UniProt

complete

enables

GO:0031694

alpha-2A adrenergic receptor binding

PMID:16531006[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P08913

F

Seeded From UniProt

complete

involved_in

GO:0106072

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:16531006[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:16531006[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21930949[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P51693

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16193067[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P51693

F

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015849
InterPro:IPR036454

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008155

C

Seeded From UniProt

complete

enables

GO:0046914

transition metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011178
InterPro:IPR036669

F

Seeded From UniProt

complete

involved_in

GO:0009887

animal organ morphogenesis

PMID:9521588[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:9521588[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

PMID:9521588[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0254

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Weber, B et al. (2006) Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase. Cell. Signal. 18 1748-57 PubMed GONUTS page
  2. Xue, Y et al. (2011) Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization. Proc. Natl. Acad. Sci. U.S.A. 108 16229-34 PubMed GONUTS page
  3. Soba, P et al. (2005) Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J. 24 3624-34 PubMed GONUTS page
  4. 4.0 4.1 4.2 Lenkkeri, U et al. (1998) Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1. Hum. Genet. 102 192-6 PubMed GONUTS page