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HUMAN:AP1S3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AP1S3
Protein Name(s) AP-1 complex subunit sigma-3

Adaptor protein complex AP-1 subunit sigma-1C Adaptor-related protein complex 1 subunit sigma-1C Clathrin assembly protein complex 1 sigma-1C small chain Golgi adaptor HA1/AP1 adaptin sigma-1C subunit Sigma 1C subunit of AP-1 clathrin Sigma-adaptin 1C Sigma1C-adaptin

External Links
UniProt Q96PC3
EMBL AF393369
AK299026
AC012512
AC093884
BC009606
BC021898
CCDS CCDS42827.1
RefSeq NP_001034658.1
UniGene Hs.632555
PDB 4HMY
PDBsum 4HMY
ProteinModelPortal Q96PC3
SMR Q96PC3
BioGrid 126229
IntAct Q96PC3
STRING 9606.ENSP00000379891
PhosphoSite Q96PC3
DMDM 21541959
MaxQB Q96PC3
PaxDb Q96PC3
PRIDE Q96PC3
Ensembl ENST00000396654
ENST00000415298
ENST00000443700
ENST00000446015
GeneID 130340
KEGG hsa:130340
UCSC uc002vnn.3
uc010fwx.2
CTD 130340
GeneCards GC02M224616
HGNC HGNC:18971
MIM 615781
neXtProt NX_Q96PC3
Orphanet 163931
247353
163927
eggNOG COG5030
GeneTree ENSGT00530000062839
HOGENOM HOG000185227
HOVERGEN HBG050517
InParanoid Q96PC3
KO K12395
OMA RTRMANF
OrthoDB EOG7S7SGC
PhylomeDB Q96PC3
TreeFam TF312921
Reactome REACT_11103
REACT_121399
REACT_19287
REACT_19400
ChiTaRS AP1S3
GenomeRNAi 130340
NextBio 82726
PRO PR:Q96PC3
Proteomes UP000005640
Bgee Q96PC3
CleanEx HS_AP1S3
ExpressionAtlas Q96PC3
Genevestigator Q96PC3
GO GO:0005905
GO:0030659
GO:0005829
GO:0000139
GO:0005765
GO:0030117
GO:0032588
GO:0008565
GO:0019886
GO:0006886
GO:0061024
GO:0006892
GO:0050690
GO:0016032
InterPro IPR016635
IPR022775
IPR000804
IPR011012
PANTHER PTHR11753
Pfam PF01217
PIRSF PIRSF015588
SUPFAM SSF64356
PROSITE PS00989

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006605

protein targeting

PMID:24791904[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000804

P

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016635

P

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000804

P

Seeded From UniProt

complete

part_of

GO:0030117

membrane coat

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000804

C

Seeded From UniProt

complete

involved_in

GO:0050690

regulation of defense response to virus by virus

Reactome:R-HSA-164940

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032588

trans-Golgi network membrane

Reactome:R-HSA-8951498
Reactome:R-HSA-5333658
Reactome:R-HSA-2213236
Reactome:R-HSA-2130641

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

Reactome:R-HSA-421836
Reactome:R-HSA-421835

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

Reactome:R-HSA-2132295

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8951498
Reactome:R-HSA-432712
Reactome:R-HSA-432688
Reactome:R-HSA-421836
Reactome:R-HSA-421833
Reactome:R-HSA-2213236
Reactome:R-HSA-2130619
Reactome:R-HSA-182286
Reactome:R-HSA-182279
Reactome:R-HSA-182263

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

Reactome:R-HSA-432707
Reactome:R-HSA-432688

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

Reactome:R-HSA-432712
Reactome:R-HSA-432707
Reactome:R-HSA-432706
Reactome:R-HSA-421835
Reactome:R-HSA-421833
Reactome:R-HSA-421831

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0005905

clathrin-coated pit

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0168
UniProtKB-SubCell:SL-0069

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0089

C

Seeded From UniProt

complete

GO:0030123

AP-3 adaptor complex

PMID:23657274[2]

ECO:0000315

C

Figure 4. Effect of AP-3 deficiency on flavivirus infection.

complete
CACAO 8958

GO:0030123

AP-3 adaptor complex

PMID:23657274[2]

ECO:0000315

C

Figure 5. Defective viral RNA replication in AP-3-deficient cells.

complete
CACAO 8959

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Setta-Kaffetzi, N et al. (2014) AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking. Am. J. Hum. Genet. 94 790-7 PubMed GONUTS page
  2. 2.0 2.1 Agrawal, T et al. (2013) Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle. Sci Rep 3 1813 PubMed GONUTS page