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HUMAN:AMNLS
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | AMN | |
| Protein Name(s) | Protein amnionless | |
| External Links | ||
| UniProt | Q9BXJ7 | |
| EMBL | AF328788 AL117209 AY358468 | |
| CCDS | CCDS9977.1 | |
| RefSeq | NP_112205.2 | |
| UniGene | Hs.534494 | |
| ProteinModelPortal | Q9BXJ7 | |
| BioGrid | 123571 | |
| STRING | 9606.ENSP00000299155 | |
| DrugBank | DB00115 DB00200 | |
| PhosphoSite | Q9BXJ7 | |
| DMDM | 296434395 | |
| MaxQB | Q9BXJ7 | |
| PaxDb | Q9BXJ7 | |
| PRIDE | Q9BXJ7 | |
| Ensembl | ENST00000299155 | |
| GeneID | 81693 | |
| KEGG | hsa:81693 | |
| UCSC | uc001ymg.4 | |
| CTD | 81693 | |
| GeneCards | GC14P103388 | |
| H-InvDB | HIX0011994 | |
| HGNC | HGNC:14604 | |
| HPA | HPA000817 | |
| MIM | 261100 605799 | |
| neXtProt | NX_Q9BXJ7 | |
| Orphanet | 35858 | |
| PharmGKB | PA134962814 | |
| eggNOG | NOG82604 | |
| GeneTree | ENSGT00390000007463 | |
| HOGENOM | HOG000033922 | |
| HOVERGEN | HBG037321 | |
| InParanoid | Q9BXJ7 | |
| KO | K18259 | |
| OMA | EAQPWIC | |
| OrthoDB | EOG7ZGX2W | |
| PhylomeDB | Q9BXJ7 | |
| TreeFam | TF323790 | |
| Reactome | REACT_13621 REACT_163862 REACT_169132 REACT_169280 | |
| GeneWiki | Amnionless | |
| GenomeRNAi | 81693 | |
| NextBio | 72043 | |
| PRO | PR:Q9BXJ7 | |
| Proteomes | UP000005640 | |
| Bgee | Q9BXJ7 | |
| CleanEx | HS_AMN | |
| ExpressionAtlas | Q9BXJ7 | |
| Genevestigator | Q9BXJ7 | |
| GO | GO:0016324 GO:0030139 GO:0010008 GO:0005615 GO:0070062 GO:0016021 GO:0005886 GO:0005102 GO:0009235 GO:0015889 GO:0007588 GO:0043001 GO:0042157 GO:0007275 GO:0006898 GO:0044281 GO:0006766 GO:0006767 | |
| InterPro | IPR026112 | |
| PANTHER | PTHR14995 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006898 |
receptor-mediated endocytosis |
ECO:0000315 |
P |
Figure 4 shows that cells not expressing AMN cannot internalize intrinsic-factor-cobalamin into the cell through receptor-mediated endocytosis, while WT cells can |
complete | |||||
|
involved_in |
GO:0006898 |
receptor-mediated endocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043001 |
Golgi to plasma membrane protein transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:O60494) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030139 |
endocytic vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002306) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002306) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0015889 |
cobalamin transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006898 |
receptor-mediated endocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
part_of:(GO:0015889) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZFK9 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031526 |
brush border membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZFK9 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030139 |
endocytic vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZFK9 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045177 |
apical part of cell |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB7 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008104 |
protein localization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB7 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007588 |
excretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99JB7 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034384 |
high-density lipoprotein particle clearance |
Reactome:R-HSA-8964011 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0010008 |
endosome membrane |
Reactome:R-HSA-3000137 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009235 |
cobalamin metabolic process |
Reactome:R-HSA-196741 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-3296477 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005905 |
clathrin-coated pit |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Pedersen, GA et al. (2010) AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2. Traffic 11 706-20 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Fyfe, JC et al. (2004) The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood 103 1573-9 PubMed GONUTS page
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