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HUMAN:ADT1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SLC25A4 (synonyms: ANT1)
Protein Name(s) ADP/ATP translocase 1

ADP,ATP carrier protein 1 ADP,ATP carrier protein, heart/skeletal muscle isoform T1 Adenine nucleotide translocator 1 ANT 1 Solute carrier family 25 member 4

External Links
UniProt P12235
EMBL J02966
J04982
HQ206346
HQ206347
HQ206348
HQ206349
HQ206350
HQ206351
HQ206352
HQ206353
HQ206354
HQ206355
HQ206356
HQ206357
HQ206358
HQ206359
HQ206360
HQ206361
HQ206362
HQ206363
HQ206364
HQ206365
HQ206366
HQ206367
HQ206368
HQ206369
HQ206370
HQ206371
HQ206372
HQ206373
HQ206374
HQ206375
HQ206376
HQ206377
HQ206378
HQ206379
HQ206380
HQ206381
HQ206382
HQ206383
HQ206384
HQ206385
CH471056
CH471056
BC008664
BC061589
BC063643
J03593
CCDS CCDS34114.1
PIR A44778
RefSeq NP_001142.2
UniGene Hs.246506
ProteinModelPortal P12235
SMR P12235
BioGrid 106788
DIP DIP-33116N
IntAct P12235
MINT MINT-196037
STRING 9606.ENSP00000281456
DrugBank DB00171
DB00720
GuidetoPHARMACOLOGY 1062
TCDB 2.A.29.1.2
PhosphoSite P12235
DMDM 113455
MaxQB P12235
PaxDb P12235
PRIDE P12235
DNASU 291
Ensembl ENST00000281456
GeneID 291
KEGG hsa:291
UCSC uc003ixd.3
CTD 291
GeneCards GC04P186064
HGNC HGNC:10990
MIM 103220
609283
615418
neXtProt NX_P12235
Orphanet 254892
1369
155
PharmGKB PA35866
eggNOG NOG238123
GeneTree ENSGT00390000011543
HOGENOM HOG000165727
HOVERGEN HBG108348
InParanoid P12235
KO K05863
OMA GSSQREF
OrthoDB EOG7T1RBR
PhylomeDB P12235
TreeFam TF300743
Reactome REACT_118595
REACT_18325
REACT_8016
ChiTaRS SLC25A4
GeneWiki SLC25A4
GenomeRNAi 291
NextBio 1187
PRO PR:P12235
Proteomes UP000005640
Bgee P12235
CleanEx HS_SLC25A4
ExpressionAtlas P12235
Genevestigator P12235
GO GO:0005887
GO:0005743
GO:0005739
GO:0005634
GO:0015207
GO:0015853
GO:0008637
GO:0006112
GO:0006091
GO:0000002
GO:0060546
GO:0050796
GO:0044281
GO:0006810
GO:0016032
Gene3D 1.50.40.10
InterPro IPR002113
IPR002067
IPR018108
IPR023395
Pfam PF00153
PRINTS PR00927
PR00926
SUPFAM SSF103506
PROSITE PS50920

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0032592

integral component of mitochondrial membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P02722

C

Seeded From UniProt

complete

involved_in

GO:0015866

ADP transport

PMID:27693233[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:20833797[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001134)

Seeded From UniProt

complete

involved_in

GO:0060546

negative regulation of necroptotic process

PMID:16507998[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005471

ATP:ADP antiporter activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003360
PANTHER:PTN000640051
PomBase:SPBC530.10c
SGD:S000000126
SGD:S000004660

F

Seeded From UniProt

complete

GO:0005741

mitochondrial outer membrane

PMID:2823266[5]

ECO:0000314

C

Figure 2 shows the autroradiographs of RNA blots of synthetic ANT translocator RNA and total human RNA.

complete
CACAO 9433

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0015853

adenine transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015207

P

Seeded From UniProt

complete

involved_in

GO:0015867

ATP transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005471

P

Seeded From UniProt

complete

involved_in

GO:0008637

apoptotic mitochondrial changes

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48962
ensembl:ENSMUSP00000034049

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002113

C

Seeded From UniProt

complete

enables

GO:0022857

transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002067
InterPro:IPR002113
InterPro:IPR040062

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002067
InterPro:IPR002113

P

Seeded From UniProt

complete

enables

GO:0015207

adenine transmembrane transporter activity

PMID:2823266[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006091

generation of precursor metabolites and energy

PMID:2823266[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:2823266[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:10926541[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000002

mitochondrial genome maintenance

PMID:10926541[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050796

regulation of insulin secretion

Reactome:R-HSA-422356

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

Reactome:R-HSA-5672027
Reactome:R-HSA-5250209
Reactome:R-HSA-180905

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Thompson, K et al. (2016) Recurrent De Novo Dominant Mutations in SLC25A4 Cause Severe Early-Onset Mitochondrial Disease and Loss of Mitochondrial DNA Copy Number. Am. J. Hum. Genet. 99 860-876 PubMed GONUTS page
  2. ↑ Zhao, X et al. (2011) Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Mol. Cell Proteomics 10 M110.000299 PubMed GONUTS page
  3. ↑ Temkin, V et al. (2006) Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol. Cell. Biol. 26 2215-25 PubMed GONUTS page
  4. ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Neckelmann, N et al. (1987) cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes. Proc. Natl. Acad. Sci. U.S.A. 84 7580-4 PubMed GONUTS page
  6. ↑ 6.0 6.1 Kaukonen, J et al. (2000) Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science 289 782-5 PubMed GONUTS page
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