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HUMAN:ADT1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | SLC25A4 (synonyms: ANT1) | |
Protein Name(s) | ADP/ATP translocase 1
ADP,ATP carrier protein 1 ADP,ATP carrier protein, heart/skeletal muscle isoform T1 Adenine nucleotide translocator 1 ANT 1 Solute carrier family 25 member 4 | |
External Links | ||
UniProt | P12235 | |
EMBL | J02966 J04982 HQ206346 HQ206347 HQ206348 HQ206349 HQ206350 HQ206351 HQ206352 HQ206353 HQ206354 HQ206355 HQ206356 HQ206357 HQ206358 HQ206359 HQ206360 HQ206361 HQ206362 HQ206363 HQ206364 HQ206365 HQ206366 HQ206367 HQ206368 HQ206369 HQ206370 HQ206371 HQ206372 HQ206373 HQ206374 HQ206375 HQ206376 HQ206377 HQ206378 HQ206379 HQ206380 HQ206381 HQ206382 HQ206383 HQ206384 HQ206385 CH471056 CH471056 BC008664 BC061589 BC063643 J03593 | |
CCDS | CCDS34114.1 | |
PIR | A44778 | |
RefSeq | NP_001142.2 | |
UniGene | Hs.246506 | |
ProteinModelPortal | P12235 | |
SMR | P12235 | |
BioGrid | 106788 | |
DIP | DIP-33116N | |
IntAct | P12235 | |
MINT | MINT-196037 | |
STRING | 9606.ENSP00000281456 | |
DrugBank | DB00171 DB00720 | |
GuidetoPHARMACOLOGY | 1062 | |
TCDB | 2.A.29.1.2 | |
PhosphoSite | P12235 | |
DMDM | 113455 | |
MaxQB | P12235 | |
PaxDb | P12235 | |
PRIDE | P12235 | |
DNASU | 291 | |
Ensembl | ENST00000281456 | |
GeneID | 291 | |
KEGG | hsa:291 | |
UCSC | uc003ixd.3 | |
CTD | 291 | |
GeneCards | GC04P186064 | |
HGNC | HGNC:10990 | |
MIM | 103220 609283 615418 | |
neXtProt | NX_P12235 | |
Orphanet | 254892 1369 155 | |
PharmGKB | PA35866 | |
eggNOG | NOG238123 | |
GeneTree | ENSGT00390000011543 | |
HOGENOM | HOG000165727 | |
HOVERGEN | HBG108348 | |
InParanoid | P12235 | |
KO | K05863 | |
OMA | GSSQREF | |
OrthoDB | EOG7T1RBR | |
PhylomeDB | P12235 | |
TreeFam | TF300743 | |
Reactome | REACT_118595 REACT_18325 REACT_8016 | |
ChiTaRS | SLC25A4 | |
GeneWiki | SLC25A4 | |
GenomeRNAi | 291 | |
NextBio | 1187 | |
PRO | PR:P12235 | |
Proteomes | UP000005640 | |
Bgee | P12235 | |
CleanEx | HS_SLC25A4 | |
ExpressionAtlas | P12235 | |
Genevestigator | P12235 | |
GO | GO:0005887 GO:0005743 GO:0005739 GO:0005634 GO:0015207 GO:0015853 GO:0008637 GO:0006112 GO:0006091 GO:0000002 GO:0060546 GO:0050796 GO:0044281 GO:0006810 GO:0016032 | |
Gene3D | 1.50.40.10 | |
InterPro | IPR002113 IPR002067 IPR018108 IPR023395 | |
Pfam | PF00153 | |
PRINTS | PR00927 PR00926 | |
SUPFAM | SSF103506 | |
PROSITE | PS50920 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0032592 |
integral component of mitochondrial membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015866 |
ADP transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001134) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060546 |
negative regulation of necroptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005471 |
ATP:ADP antiporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003360 |
F |
Seeded From UniProt |
complete | ||
GO:0005741 |
mitochondrial outer membrane |
ECO:0000314 |
C |
Figure 2 shows the autroradiographs of RNA blots of synthetic ANT translocator RNA and total human RNA. |
complete | |||||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015853 |
adenine transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0015207 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0015867 |
ATP transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005471 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008637 |
apoptotic mitochondrial changes |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48962 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0022857 |
transmembrane transporter activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0015207 |
adenine transmembrane transporter activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006091 |
generation of precursor metabolites and energy |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000002 |
mitochondrial genome maintenance |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050796 |
regulation of insulin secretion |
Reactome:R-HSA-422356 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005743 |
mitochondrial inner membrane |
Reactome:R-HSA-5672027 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Thompson, K et al. (2016) Recurrent De Novo Dominant Mutations in SLC25A4 Cause Severe Early-Onset Mitochondrial Disease and Loss of Mitochondrial DNA Copy Number. Am. J. Hum. Genet. 99 860-876 PubMed GONUTS page
- ↑ Zhao, X et al. (2011) Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Mol. Cell Proteomics 10 M110.000299 PubMed GONUTS page
- ↑ Temkin, V et al. (2006) Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol. Cell. Biol. 26 2215-25 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Neckelmann, N et al. (1987) cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes. Proc. Natl. Acad. Sci. U.S.A. 84 7580-4 PubMed GONUTS page
- ↑ 6.0 6.1 Kaukonen, J et al. (2000) Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science 289 782-5 PubMed GONUTS page
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