HUMAN:ADR1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ADIPOR1 (synonyms: PAQR1, TESBP1A)
Protein Name(s)	Adiponectin receptor protein 1 Progestin and adipoQ receptor family member I
External Links
UniProt	Q96A54
EMBL	AY424279 AF125179 AF151803 AK001484 AK222503 CH471067 BC001594 BC010743
CCDS	CCDS1430.1
RefSeq	NP_001277482.1 NP_001277486.1 NP_001277558.1 NP_057083.2
UniGene	Hs.5298 Hs.713729
ProteinModelPortal	Q96A54
BioGrid	119283
DIP	DIP-48622N
IntAct	Q96A54
STRING	9606.ENSP00000341785
GuidetoPHARMACOLOGY	649
PhosphoSite	Q96A54
DMDM	38372248
MaxQB	Q96A54
PaxDb	Q96A54
PRIDE	Q96A54
DNASU	51094
Ensembl	ENST00000340990
GeneID	51094
KEGG	hsa:51094
UCSC	uc001gyq.5
CTD	51094
GeneCards	GC01M202909
HGNC	HGNC:24040
HPA	HPA048306
MIM	607945
neXtProt	NX_Q96A54
PharmGKB	PA134861801
eggNOG	COG1272
GeneTree	ENSGT00530000062926
HOGENOM	HOG000197115
HOVERGEN	HBG013916
InParanoid	Q96A54
KO	K07297
OMA	EQACPVP
OrthoDB	EOG7BS49P
PhylomeDB	Q96A54
TreeFam	TF313640
ChiTaRS	ADIPOR1
GeneWiki	ADIPOR1
GenomeRNAi	51094
NextBio	53785
PRO	PR:Q96A54
Proteomes	UP000005640
Bgee	Q96A54
CleanEx	HS_ADIPOR1
ExpressionAtlas	Q96A54
Genevestigator	Q96A54
GO	GO:0016021 GO:0016020 GO:0005886 GO:0042562 GO:0019901 GO:0004872 GO:0033211 GO:0019395 GO:0009755 GO:0033210 GO:0030308 GO:0046628 GO:0046427
InterPro	IPR004254
PANTHER	PTHR20855
Pfam	PF03006

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:24531262^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91VH1	P		Seeded From UniProt	complete
involved_in	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	PMID:23776679^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000066)	Seeded From UniProt	complete
involved_in	GO:1901223	negative regulation of NIK/NF-kappaB signaling	PMID:23776679^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000066)	Seeded From UniProt	complete
involved_in	GO:0010633	negative regulation of epithelial cell migration	PMID:23776679^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010719	negative regulation of epithelial to mesenchymal transition	PMID:23776679^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097003	adipokinetic hormone receptor activity	PMID:12802337^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0055100	adiponectin binding	PMID:12802337^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	PMID:12802337^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91VH1	P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91VH1	P		Seeded From UniProt	complete
involved_in	GO:0010906	regulation of glucose metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91VH1	P		Seeded From UniProt	complete
involved_in	GO:0033211	adiponectin-activated signaling pathway	PMID:12802337^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:19233263^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P67870	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19233263^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	PMID:12802337^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	PMID:12802337^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919924 MGI:MGI:93830 PANTHER:PTN000465443	F		Seeded From UniProt	complete
involved_in	GO:0033211	adiponectin-activated signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919924 MGI:MGI:93830 PANTHER:PTN001074076 RGD:1303151 UniProtKB:Q86V24 UniProtKB:Q96A54	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919924 MGI:MGI:93830 PANTHER:PTN001074076 RGD:1303151 UniProtKB:Q96A54 WB:WBGene00021313	C		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6I6 ensembl:ENSRNOP00000005551	P		Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6I6 ensembl:ENSRNOP00000005551	P		Seeded From UniProt	complete
involved_in	GO:0033211	adiponectin-activated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6I6 ensembl:ENSRNOP00000005551	P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6I6 ensembl:ENSRNOP00000005551	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6I6 ensembl:ENSRNOP00000005551	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V6I6 ensembl:ENSRNOP00000005551	C		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH1 ensembl:ENSMUSP00000107856	P		Seeded From UniProt	complete
enables	GO:0055100	adiponectin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH1 ensembl:ENSMUSP00000107856	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH1 ensembl:ENSMUSP00000107856	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH1 ensembl:ENSMUSP00000107856	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH1 ensembl:ENSMUSP00000107856	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH1 ensembl:ENSMUSP00000107856	F		Seeded From UniProt	complete
involved_in	GO:0033211	adiponectin-activated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH1 ensembl:ENSMUSP00000107856	P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH1 ensembl:ENSMUSP00000107856	P		Seeded From UniProt	complete
involved_in	GO:0010906	regulation of glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH1 ensembl:ENSMUSP00000107856	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH1 ensembl:ENSMUSP00000107856	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004254	C		Seeded From UniProt	complete
involved_in	GO:0042304	regulation of fatty acid biosynthetic process	Reactome:R-HSA-163680	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8848663	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Qiao, L et al. (2014) Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia 57 1027-36 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Hwang, MS et al. (2013) miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer. PLoS ONE 8 e66502 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Yamauchi, T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423 762-9 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^5.0 ^5.1 Heiker, JT et al. (2009) Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling. Cell. Signal. 21 936-42 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24531262-1] Qiao, L et al. (2014) Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia 57 1027-36 PubMed GONUTS page

[PMID:23776679-2] 2.0 ^2.1 ^2.2 ^2.3 Hwang, MS et al. (2013) miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer. PLoS ONE 8 e66502 PubMed GONUTS page

[PMID:12802337-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Yamauchi, T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423 762-9 PubMed GONUTS page

[PMID:19946888-4] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19233263-5] 5.0 ^5.1 Heiker, JT et al. (2009) Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling. Cell. Signal. 21 936-42 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

HUMAN:ADR1

Contents

Annotations

Notes

References

a

c

e

f

g

h

i

l

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools