HUMAN:ACTHR

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MC2R (synonyms: ACTHR)
Protein Name(s)	Adrenocorticotropic hormone receptor ACTH receptor ACTH-R Adrenocorticotropin receptor Melanocortin receptor 2 MC2-R
External Links
UniProt	Q01718
EMBL	X65633 AB065915 AK289381 AK315319 CH471113 BC069074 BC094710 BC104169 BC104170 AY225229
CCDS	CCDS11869.1
PIR	C43265
RefSeq	NP_000520.1 NP_001278840.1
UniGene	Hs.248144
ProteinModelPortal	Q01718
SMR	Q01718
BioGrid	110328
DIP	DIP-29949N
IntAct	Q01718
STRING	9606.ENSP00000333821
BindingDB	Q01718
ChEMBL	CHEMBL1965
DrugBank	DB01285 DB01284
GuidetoPHARMACOLOGY	283
TCDB	9.A.14.2.4
PhosphoSite	Q01718
DMDM	399002
PRIDE	Q01718
Ensembl	ENST00000327606
GeneID	4158
KEGG	hsa:4158
UCSC	uc002ksp.1
CTD	4158
GeneCards	GC18M013874
HGNC	HGNC:6930
MIM	202200 607397
neXtProt	NX_Q01718
Orphanet	361
PharmGKB	PA30674
eggNOG	NOG331926
GeneTree	ENSGT00770000120529
HOGENOM	HOG000246927
HOVERGEN	HBG108148
InParanoid	Q01718
KO	K04200
OMA	KPRGNFE
OrthoDB	EOG7327PD
PhylomeDB	Q01718
TreeFam	TF332646
Reactome	REACT_14819 REACT_19327
GeneWiki	ACTH_receptor
GenomeRNAi	4158
NextBio	16382
PRO	PR:Q01718
Proteomes	UP000005640
Bgee	Q01718
CleanEx	HS_MC2R
ExpressionAtlas	Q01718
Genevestigator	Q01718
GO	GO:0005737 GO:0005887 GO:0005886 GO:0004978 GO:0004977 GO:0007186 GO:0007187 GO:0007218 GO:0001890 GO:0030819
InterPro	IPR001168 IPR000276 IPR017452 IPR001671
PANTHER	PTHR22750:SF3
Pfam	PF00001
PRINTS	PR00520 PR00237 PR00534
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:19329486^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004978	P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004978	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V848 ensembl:ENSRNOP00000022347	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V848 ensembl:ENSRNOP00000022347	C	Seeded From UniProt	complete
involved_in	GO:0001890	placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V848 ensembl:ENSRNOP00000022347	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
enables	GO:0004977	melanocortin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001671	F	Seeded From UniProt	complete
enables	GO:0004978	corticotropin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001168	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR001168 InterPro:IPR001671	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR001168 InterPro:IPR001671 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:9175632^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:1325670^[3] Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9175632^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004978	corticotropin receptor activity	PMID:9175632^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004977	melanocortin receptor activity	PMID:1325670^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-744887 Reactome:R-HSA-744886 Reactome:R-HSA-5603251 Reactome:R-HSA-388605 Reactome:R-HSA-379044	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Chan, LF et al. (2009) MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc. Natl. Acad. Sci. U.S.A. 106 6146-51 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Naville, D et al. (1997) Stable expression of normal and mutant human ACTH receptor: study of ACTH binding and coupling to adenylate cyclase. Mol. Cell. Endocrinol. 129 83-90 PubMed GONUTS page
↑ ^3.0 ^3.1 Mountjoy, KG et al. (1992) The cloning of a family of genes that encode the melanocortin receptors. Science 257 1248-51 PubMed GONUTS page

[PMID:19329486-1] Chan, LF et al. (2009) MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc. Natl. Acad. Sci. U.S.A. 106 6146-51 PubMed GONUTS page

[PMID:9175632-2] 2.0 ^2.1 ^2.2 Naville, D et al. (1997) Stable expression of normal and mutant human ACTH receptor: study of ACTH binding and coupling to adenylate cyclase. Mol. Cell. Endocrinol. 129 83-90 PubMed GONUTS page

[PMID:1325670-3] 3.0 ^3.1 Mountjoy, KG et al. (1992) The cloning of a family of genes that encode the melanocortin receptors. Science 257 1248-51 PubMed GONUTS page

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HUMAN:ACTHR

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