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HUMAN:AAKB1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | PRKAB1 (synonyms: AMPK) | |
Protein Name(s) | 5'-AMP-activated protein kinase subunit beta-1
AMPK subunit beta-1 AMPKb | |
External Links | ||
UniProt | Q9Y478 | |
EMBL | AJ224515 Y12556 U83994 U87276 U87271 U87272 U87273 U87274 U87275 AF022116 AC002563 BC001007 BC001056 BC001823 BC017671 | |
CCDS | CCDS9191.1 | |
PIR | T09514 | |
RefSeq | NP_006244.2 XP_005253966.1 | |
UniGene | Hs.741184 | |
PDB | 4CFE 4CFF | |
PDBsum | 4CFE 4CFF | |
ProteinModelPortal | Q9Y478 | |
SMR | Q9Y478 | |
BioGrid | 111551 | |
IntAct | Q9Y478 | |
MINT | MINT-1400840 | |
STRING | 9606.ENSP00000229328 | |
BindingDB | Q9Y478 | |
ChEMBL | CHEMBL2096907 | |
DrugBank | DB00945 DB00131 DB00331 | |
CAZy | CBM48 | |
PhosphoSite | Q9Y478 | |
DMDM | 14194425 | |
MaxQB | Q9Y478 | |
PaxDb | Q9Y478 | |
PRIDE | Q9Y478 | |
Ensembl | ENST00000229328 ENST00000541640 | |
GeneID | 5564 | |
KEGG | hsa:5564 | |
UCSC | uc001txg.3 | |
CTD | 5564 | |
GeneCards | GC12P120105 | |
HGNC | HGNC:9378 | |
HPA | CAB005058 HPA004247 | |
MIM | 602740 | |
neXtProt | NX_Q9Y478 | |
PharmGKB | PA33746 | |
eggNOG | NOG238368 | |
GeneTree | ENSGT00390000001416 | |
HOGENOM | HOG000230597 | |
HOVERGEN | HBG050430 | |
KO | K07199 | |
OMA | SKDGDRP | |
OrthoDB | EOG7SXW3Z | |
PhylomeDB | Q9Y478 | |
TreeFam | TF313827 | |
Reactome | REACT_147867 REACT_200686 REACT_21285 REACT_21393 | |
SignaLink | Q9Y478 | |
GeneWiki | PRKAB1 | |
GenomeRNAi | 5564 | |
NextBio | 21556 | |
PRO | PR:Q9Y478 | |
Proteomes | UP000005640 | |
Bgee | Q9Y478 | |
CleanEx | HS_PRKAB1 | |
ExpressionAtlas | Q9Y478 | |
Genevestigator | Q9Y478 | |
GO | GO:0031588 GO:0005829 GO:0005634 GO:0004679 GO:0004672 GO:0007050 GO:0006633 GO:0008286 GO:0061024 GO:0010628 GO:0051291 GO:0006468 GO:0050790 GO:0007165 | |
InterPro | IPR030080 IPR006828 IPR014756 | |
PANTHER | PTHR10343:SF16 | |
Pfam | PF04739 | |
SMART | SM01010 | |
SUPFAM | SSF81296 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q8NFG4)|has_regulation_target:(UniProtKB:Q8TF40) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(UniProtKB:Q8TF40) |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0031588 |
nucleotide-activated protein kinase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000038857 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000038857 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000038857 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1336167 |
C |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0004679 |
AMP-activated protein kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000038857 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051291 |
protein heterooligomerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P80386 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050790 |
regulation of catalytic activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P80386 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P80386 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0031588 |
nucleotide-activated protein kinase complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P80386 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P80386 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004679 |
AMP-activated protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P80386 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R078 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035878 |
nail development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R078 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R078 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050790 |
regulation of catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901796 |
regulation of signal transduction by p53 class mediator |
Reactome:R-HSA-5633007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016241 |
regulation of macroautophagy |
Reactome:R-HSA-5673768 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016236 |
macroautophagy |
Reactome:R-HSA-1632852 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007050 |
cell cycle arrest |
Reactome:R-HSA-380972 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5679239 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6805470 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Mottillo, EP et al. (2016) Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Cell Metab. 24 118-29 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Baba, M et al. (2006) Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. U.S.A. 103 15552-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Thornton, C et al. (1998) Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. J. Biol. Chem. 273 12443-50 PubMed GONUTS page
c
n
p
- GO:0010628 ! positive regulation of gene expression
- GO:0120162 ! positive regulation of cold-induced thermogenesis
- Primates
- GO:0032991 ! protein-containing complex
- GO:0051291 ! protein heterooligomerization
- GO:0019901 ! protein kinase binding
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
r