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HUMAN:AAKB1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PRKAB1 (synonyms: AMPK)
Protein Name(s) 5'-AMP-activated protein kinase subunit beta-1

AMPK subunit beta-1 AMPKb

External Links
UniProt Q9Y478
EMBL AJ224515
Y12556
U83994
U87276
U87271
U87272
U87273
U87274
U87275
AF022116
AC002563
BC001007
BC001056
BC001823
BC017671
CCDS CCDS9191.1
PIR T09514
RefSeq NP_006244.2
XP_005253966.1
UniGene Hs.741184
PDB 4CFE
4CFF
PDBsum 4CFE
4CFF
ProteinModelPortal Q9Y478
SMR Q9Y478
BioGrid 111551
IntAct Q9Y478
MINT MINT-1400840
STRING 9606.ENSP00000229328
BindingDB Q9Y478
ChEMBL CHEMBL2096907
DrugBank DB00945
DB00131
DB00331
CAZy CBM48
PhosphoSite Q9Y478
DMDM 14194425
MaxQB Q9Y478
PaxDb Q9Y478
PRIDE Q9Y478
Ensembl ENST00000229328
ENST00000541640
GeneID 5564
KEGG hsa:5564
UCSC uc001txg.3
CTD 5564
GeneCards GC12P120105
HGNC HGNC:9378
HPA CAB005058
HPA004247
MIM 602740
neXtProt NX_Q9Y478
PharmGKB PA33746
eggNOG NOG238368
GeneTree ENSGT00390000001416
HOGENOM HOG000230597
HOVERGEN HBG050430
KO K07199
OMA SKDGDRP
OrthoDB EOG7SXW3Z
PhylomeDB Q9Y478
TreeFam TF313827
Reactome REACT_147867
REACT_200686
REACT_21285
REACT_21393
SignaLink Q9Y478
GeneWiki PRKAB1
GenomeRNAi 5564
NextBio 21556
PRO PR:Q9Y478
Proteomes UP000005640
Bgee Q9Y478
CleanEx HS_PRKAB1
ExpressionAtlas Q9Y478
Genevestigator Q9Y478
GO GO:0031588
GO:0005829
GO:0005634
GO:0004679
GO:0004672
GO:0007050
GO:0006633
GO:0008286
GO:0061024
GO:0010628
GO:0051291
GO:0006468
GO:0050790
GO:0007165
InterPro IPR030080
IPR006828
IPR014756
PANTHER PTHR10343:SF16
Pfam PF04739
SMART SM01010
SUPFAM SSF81296

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:27411013[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9R078

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:17028174[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q8NFG4)|has_regulation_target:(UniProtKB:Q8TF40)

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:17028174[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_input:(UniProtKB:Q8TF40)

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:17028174[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
PomBase:SPCC1919.03c
RGD:620905
RGD:71057
SGD:S000000829
SGD:S000003176
UniProtKB:O43741

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
RGD:620905
RGD:71057

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
PomBase:SPCC1919.03c
RGD:620905
SGD:S000000829
SGD:S000003176

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1336167
PANTHER:PTN000038857
PomBase:SPCC1919.03c
SGD:S000000829

C

Seeded From UniProt

complete

contributes_to

GO:0004679

AMP-activated protein kinase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
RGD:71057
SGD:S000000829
SGD:S000003176
UniProtKB:O43741

F

Seeded From UniProt

complete

involved_in

GO:0051291

protein heterooligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

P

Seeded From UniProt

complete

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

C

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

F

Seeded From UniProt

complete

enables

GO:0004679

AMP-activated protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

F

Seeded From UniProt

complete

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R078
ensembl:ENSMUSP00000031486

P

Seeded From UniProt

complete

involved_in

GO:0035878

nail development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R078
ensembl:ENSMUSP00000031486

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R078
ensembl:ENSMUSP00000031486

C

Seeded From UniProt

complete

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039160

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9575201[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016241

regulation of macroautophagy

Reactome:R-HSA-5673768

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

Reactome:R-HSA-1632852

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

Reactome:R-HSA-380972

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5679239
Reactome:R-HSA-5679205
Reactome:R-HSA-5675868
Reactome:R-HSA-5673768
Reactome:R-HSA-5672011
Reactome:R-HSA-5672008
Reactome:R-HSA-5665868
Reactome:R-HSA-5631941
Reactome:R-HSA-447074
Reactome:R-HSA-380949
Reactome:R-HSA-380930
Reactome:R-HSA-380927
Reactome:R-HSA-200421
Reactome:R-HSA-1632857

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6805470

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Mottillo, EP et al. (2016) Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Cell Metab. 24 118-29 PubMed GONUTS page
  2. 2.0 2.1 2.2 Baba, M et al. (2006) Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. U.S.A. 103 15552-7 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Thornton, C et al. (1998) Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. J. Biol. Chem. 273 12443-50 PubMed GONUTS page