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HUMAN:AAKB1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PRKAB1 (synonyms: AMPK)
Protein Name(s) 5'-AMP-activated protein kinase subunit beta-1

AMPK subunit beta-1 AMPKb

External Links
UniProt Q9Y478
EMBL AJ224515
Y12556
U83994
U87276
U87271
U87272
U87273
U87274
U87275
AF022116
AC002563
BC001007
BC001056
BC001823
BC017671
CCDS CCDS9191.1
PIR T09514
RefSeq NP_006244.2
XP_005253966.1
UniGene Hs.741184
PDB 4CFE
4CFF
PDBsum 4CFE
4CFF
ProteinModelPortal Q9Y478
SMR Q9Y478
BioGrid 111551
IntAct Q9Y478
MINT MINT-1400840
STRING 9606.ENSP00000229328
BindingDB Q9Y478
ChEMBL CHEMBL2096907
DrugBank DB00945
DB00131
DB00331
CAZy CBM48
PhosphoSite Q9Y478
DMDM 14194425
MaxQB Q9Y478
PaxDb Q9Y478
PRIDE Q9Y478
Ensembl ENST00000229328
ENST00000541640
GeneID 5564
KEGG hsa:5564
UCSC uc001txg.3
CTD 5564
GeneCards GC12P120105
HGNC HGNC:9378
HPA CAB005058
HPA004247
MIM 602740
neXtProt NX_Q9Y478
PharmGKB PA33746
eggNOG NOG238368
GeneTree ENSGT00390000001416
HOGENOM HOG000230597
HOVERGEN HBG050430
KO K07199
OMA SKDGDRP
OrthoDB EOG7SXW3Z
PhylomeDB Q9Y478
TreeFam TF313827
Reactome REACT_147867
REACT_200686
REACT_21285
REACT_21393
SignaLink Q9Y478
GeneWiki PRKAB1
GenomeRNAi 5564
NextBio 21556
PRO PR:Q9Y478
Proteomes UP000005640
Bgee Q9Y478
CleanEx HS_PRKAB1
ExpressionAtlas Q9Y478
Genevestigator Q9Y478
GO GO:0031588
GO:0005829
GO:0005634
GO:0004679
GO:0004672
GO:0007050
GO:0006633
GO:0008286
GO:0061024
GO:0010628
GO:0051291
GO:0006468
GO:0050790
GO:0007165
InterPro IPR030080
IPR006828
IPR014756
PANTHER PTHR10343:SF16
Pfam PF04739
SMART SM01010
SUPFAM SSF81296

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:27411013[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9R078

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:17028174[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q8NFG4)|has_regulation_target:(UniProtKB:Q8TF40)

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:17028174[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_input:(UniProtKB:Q8TF40)

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:17028174[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
PomBase:SPCC1919.03c
RGD:620905
RGD:71057
SGD:S000000829
SGD:S000003176
UniProtKB:O43741

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
RGD:620905
RGD:71057

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
PomBase:SPCC1919.03c
RGD:620905
SGD:S000000829
SGD:S000003176

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1336167
PANTHER:PTN000038857
PomBase:SPCC1919.03c
SGD:S000000829

C

Seeded From UniProt

complete

contributes_to

GO:0004679

AMP-activated protein kinase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000038857
RGD:71057
SGD:S000000829
SGD:S000003176
UniProtKB:O43741

F

Seeded From UniProt

complete

involved_in

GO:0051291

protein heterooligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

P

Seeded From UniProt

complete

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

C

Seeded From UniProt

complete

part_of

GO:0031588

nucleotide-activated protein kinase complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

F

Seeded From UniProt

complete

enables

GO:0004679

AMP-activated protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P80386
ensembl:ENSRNOP00000001508

F

Seeded From UniProt

complete

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R078
ensembl:ENSMUSP00000031486

P

Seeded From UniProt

complete

involved_in

GO:0035878

nail development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R078
ensembl:ENSMUSP00000031486

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R078
ensembl:ENSMUSP00000031486

C

Seeded From UniProt

complete

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039160

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9575201[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016241

regulation of macroautophagy

Reactome:R-HSA-5673768

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

Reactome:R-HSA-1632852

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

Reactome:R-HSA-380972

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5679239
Reactome:R-HSA-5679205
Reactome:R-HSA-5675868
Reactome:R-HSA-5673768
Reactome:R-HSA-5672011
Reactome:R-HSA-5672008
Reactome:R-HSA-5665868
Reactome:R-HSA-5631941
Reactome:R-HSA-447074
Reactome:R-HSA-380949
Reactome:R-HSA-380930
Reactome:R-HSA-380927
Reactome:R-HSA-200421
Reactome:R-HSA-1632857

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6805470

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Mottillo, EP et al. (2016) Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Cell Metab. 24 118-29 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Baba, M et al. (2006) Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. U.S.A. 103 15552-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Thornton, C et al. (1998) Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. J. Biol. Chem. 273 12443-50 PubMed GONUTS page
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