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HUMAN:5HT2C

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HTR2C (synonyms: HTR1C)
Protein Name(s) 5-hydroxytryptamine receptor 2C

5-HT-2C 5-HT2C 5-HTR2C 5-hydroxytryptamine receptor 1C 5-HT-1C 5-HT1C Serotonin receptor 2C

External Links
UniProt P28335
EMBL M81778
X80763
U49516
AF208053
AF498983
AK295753
AC007022
AC007025
AL591402
AL355812
AC004822
AL590097
AC004822
AL355812
AL590097
AC004822
AL590097
AC004822
AL355812
BC095543
CCDS CCDS14564.1
CCDS59174.1
PIR JS0616
RefSeq NP_000859.1
NP_001243689.1
NP_001243690.1
UniGene Hs.149037
ProteinModelPortal P28335
SMR P28335
BioGrid 109590
IntAct P28335
MINT MINT-443944
STRING 9606.ENSP00000276198
BindingDB P28335
ChEMBL CHEMBL2096904
DrugBank DB06594
DB00321
DB00543
DB00714
DB01238
DB06216
DB01200
DB00248
DB00477
DB01239
DB01242
DB00363
DB00434
DB01151
DB01191
DB01142
DB01049
DB00696
DB00458
DB01221
DB00589
DB04871
DB00408
DB00934
DB01403
DB00247
DB06148
DB00805
DB00370
DB01149
DB00540
DB00334
DB01267
DB01186
DB00413
DB00420
DB00777
DB01224
DB00734
DB00268
DB06144
DB00193
DB00656
DB00726
DB01392
DB00246
GuidetoPHARMACOLOGY 8
PhosphoSite P28335
DMDM 112816
PaxDb P28335
PRIDE P28335
Ensembl ENST00000276198
ENST00000371950
ENST00000371951
GeneID 3358
KEGG hsa:3358
UCSC uc004epu.1
uc004epv.1
CTD 3358
GeneCards GC0XP113818
HGNC HGNC:5295
HPA CAB006857
HPA003133
MIM 312861
neXtProt NX_P28335
PharmGKB PA194
eggNOG NOG247243
HOGENOM HOG000240378
HOVERGEN HBG107487
InParanoid P28335
KO K04157
OMA CCKRNTD
OrthoDB EOG70ZZN5
PhylomeDB P28335
TreeFam TF316350
Reactome REACT_17064
REACT_18283
SignaLink P28335
GeneWiki 5-HT2C_receptor
GenomeRNAi 3358
NextBio 13278
PRO PR:P28335
Proteomes UP000005640
Bgee P28335
CleanEx HS_HTR2C
ExpressionAtlas P28335
Genevestigator P28335
GO GO:0005887
GO:0005886
GO:0071886
GO:0008144
GO:0001587
GO:0051378
GO:0004993
GO:0001662
GO:0006874
GO:0006182
GO:0007631
GO:0007626
GO:0007200
GO:0007208
GO:0051482
GO:0070374
GO:0010513
GO:0032098
GO:0043397
GO:0031644
GO:0051209
GO:0042493
GO:0007210
GO:0007268
InterPro IPR000377
IPR002231
IPR000276
IPR017452
PANTHER PTHR24247:SF32
Pfam PF00001
PRINTS PR00517
PR01101
PR00237
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0010608

posttranscriptional regulation of gene expression

PMID:25288656[1]

ECO:0000315

P

Figure 4 shows HTR2C gene locus. Genomic mapping of HTR2C transcripts

complete
CACAO 10516

enables

GO:0071886

1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

PMID:19057895[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:19057895[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051482

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P34968

P

Seeded From UniProt

complete

enables

GO:0051378

serotonin binding

PMID:15831837[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051378

serotonin binding

PMID:19057895[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

PMID:18703043[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043397

regulation of corticotropin-releasing hormone secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P34968

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:18703043[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032098

regulation of appetite

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P34968

P

Seeded From UniProt

complete

involved_in

GO:0031644

regulation of neurological system process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P34968

P

Seeded From UniProt

complete

involved_in

GO:0010513

positive regulation of phosphatidylinositol biosynthetic process

PMID:19057895[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

PMID:15831837[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008144

drug binding

PMID:12970106[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008144

drug binding

PMID:18703043[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P34968

P

Seeded From UniProt

complete

involved_in

GO:0007210

serotonin receptor signaling pathway

PMID:18703043[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007208

phospholipase C-activating serotonin receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P34968

P

Seeded From UniProt

complete

involved_in

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

PMID:12970106[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006874

cellular calcium ion homeostasis

PMID:19057895[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019934

cGMP-mediated signaling

PMID:12970106[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:18703043[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:12970106[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:18703043[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001662

behavioral fear response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P34968

P

Seeded From UniProt

complete

enables

GO:0001587

Gq/11-coupled serotonin receptor activity

PMID:18703043[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664115
UniProtKB:O46635
UniProtKB:P28223
UniProtKB:P28335

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664115
RGD:2848
RGD:61800
UniProtKB:O46635
UniProtKB:P28223
UniProtKB:P28335

P

Seeded From UniProt

complete

enables

GO:0030594

neurotransmitter receptor activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664111
RGD:71034

F

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664111
RGD:2342
RGD:2343
RGD:2518
RGD:2522
RGD:2851
RGD:61800
RGD:61801
RGD:620023
RGD:62044
RGD:71034

C

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664111
RGD:2830
RGD:2846

P

Seeded From UniProt

complete

involved_in

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664115
UniProtKB:P28335

P

Seeded From UniProt

complete

involved_in

GO:0007187

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664111
RGD:2851
RGD:62044

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000037
PANTHER:PTN000664111
RGD:2343
UniProtKB:P08172
UniProtKB:P08908
UniProtKB:P21917
UniProtKB:P28221
UniProtKB:P28222
UniProtKB:P28335
UniProtKB:P28566
UniProtKB:P30546
UniProtKB:P30939
WB:WBGene00001519

C

Seeded From UniProt

complete

enables

GO:0004993

G protein-coupled serotonin receptor activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004168
FB:FBgn0004573
FB:FBgn0087012
FB:FBgn0263116
MGI:MGI:109323
MGI:MGI:96273
MGI:MGI:96274
MGI:MGI:96276
MGI:MGI:96281
MGI:MGI:96284
PANTHER:PTN000664111
RGD:2845
RGD:2846
RGD:2848
RGD:2850
RGD:2851
RGD:61800
RGD:62044
RGD:62388
RGD:71034
UniProtKB:A0A0B4KFU6
UniProtKB:P08908
UniProtKB:P28221
UniProtKB:P28222
UniProtKB:P28223
UniProtKB:P28335
UniProtKB:P28566
UniProtKB:P30939
UniProtKB:P41595
UniProtKB:P47898
UniProtKB:Q13639
WB:WBGene00004776
WB:WBGene00004779

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664111
RGD:2518

F

Seeded From UniProt

complete

enables

GO:0051378

serotonin binding

PMID:7582481[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004993

G protein-coupled serotonin receptor activity

PMID:7582481[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051482

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34968
ensembl:ENSMUSP00000094021

P

Seeded From UniProt

complete

involved_in

GO:0045600

positive regulation of fat cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34968
ensembl:ENSMUSP00000094021

P

Seeded From UniProt

complete

involved_in

GO:0043397

regulation of corticotropin-releasing hormone secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34968
ensembl:ENSMUSP00000094021

P

Seeded From UniProt

complete

involved_in

GO:0032098

regulation of appetite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34968
ensembl:ENSMUSP00000094021

P

Seeded From UniProt

complete

involved_in

GO:0031644

regulation of neurological system process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34968
ensembl:ENSMUSP00000094021

P

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34968
ensembl:ENSMUSP00000094021

P

Seeded From UniProt

complete

involved_in

GO:0007208

phospholipase C-activating serotonin receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34968
ensembl:ENSMUSP00000094021

P

Seeded From UniProt

complete

enables

GO:0004993

G protein-coupled serotonin receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34968
ensembl:ENSMUSP00000094021

F

Seeded From UniProt

complete

involved_in

GO:0001662

behavioral fear response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P34968
ensembl:ENSMUSP00000094021

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004993

G protein-coupled serotonin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000377
InterPro:IPR002231

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000377
InterPro:IPR002231

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000377
InterPro:IPR002231

P

Seeded From UniProt

complete

involved_in

GO:0007626

locomotory behavior

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000377

P

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000377

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR017452

C

Seeded From UniProt

complete

involved_in

GO:0007631

feeding behavior

PMID:7700379[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

PMID:9241279[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-390930
Reactome:R-HSA-379048

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007610

behavior

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0085

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Hinske, LC et al. (2014) miRIAD-integrating microRNA inter- and intragenic data. Database (Oxford) 2014 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Knauer, CS et al. (2009) Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors. Naunyn Schmiedebergs Arch. Pharmacol. 379 461-71 PubMed GONUTS page
  3. ↑ 3.0 3.1 Setola, V et al. (2005) Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor. Mol. Pharmacol. 68 20-33 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Cussac, D et al. (2008) Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. Eur. J. Pharmacol. 594 32-8 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Schaerlinger, B et al. (2003) Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Br. J. Pharmacol. 140 277-84 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 Bonhaus, DW et al. (1995) The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br. J. Pharmacol. 115 622-8 PubMed GONUTS page
  8. ↑ Tecott, LH et al. (1995) Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374 542-6 PubMed GONUTS page
  9. ↑ Brennan, TJ et al. (1997) Sound-induced seizures in serotonin 5-HT2c receptor mutant mice. Nat. Genet. 16 387-90 PubMed GONUTS page
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