HUMAN:5HT1A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HTR1A (synonyms: ADRB2RL1, ADRBRL1)
Protein Name(s)	5-hydroxytryptamine receptor 1A 5-HT-1A 5-HT1A G-21 Serotonin receptor 1A
External Links
UniProt	P08908
EMBL	M28269 X13556 X57829 M83181 AB041403 AF498978 BC069159 Z11168
CCDS	CCDS34168.1
PIR	I38209
RefSeq	NP_000515.2
UniGene	Hs.247940
ProteinModelPortal	P08908
SMR	P08908
BioGrid	109582
IntAct	P08908
STRING	9606.ENSP00000316244
BindingDB	P08908
ChEMBL	CHEMBL2111460
DrugBank	DB01614 DB00866 DB01616 DB00321 DB00543 DB00714 DB01238 DB06216 DB08807 DB01200 DB00490 DB00248 DB00477 DB08810 DB00363 DB01151 DB00988 DB01142 DB00216 DB01049 DB00696 DB04946 DB00458 DB01221 DB00589 DB00408 DB08815 DB00247 DB06148 DB01618 DB00952 DB01149 DB00540 DB00334 DB00904 DB01267 DB01359 DB01186 DB00960 DB01621 DB00413 DB00571 DB01224 DB00734 DB00268 DB05271 DB00669 DB01622 DB00656 DB00726 DB06684 DB01392 DB00246 DB00315
GuidetoPHARMACOLOGY	1
PhosphoSite	P08908
DMDM	231454
PaxDb	P08908
PRIDE	P08908
DNASU	3350
Ensembl	ENST00000323865
GeneID	3350
KEGG	hsa:3350
UCSC	uc011cqt.3
CTD	3350
GeneCards	GC05M063292
HGNC	HGNC:5286
HPA	HPA018073
MIM	109760 614674
neXtProt	NX_P08908
PharmGKB	PA192
eggNOG	NOG249628
HOGENOM	HOG000239242
HOVERGEN	HBG106962
InParanoid	P08908
KO	K04153
OMA	GESGSRN
PhylomeDB	P08908
TreeFam	TF316350
Reactome	REACT_17064 REACT_19231
GenomeRNAi	3350
NextBio	13248
PRO	PR:P08908
Proteomes	UP000005640
Bgee	P08908
CleanEx	HS_HTR1A
ExpressionAtlas	P08908
Genevestigator	P08908
GO	GO:0005887 GO:0005886 GO:0004993 GO:0007198 GO:0001662 GO:0008283 GO:0035640 GO:0007186 GO:0008284 GO:0050795 GO:0042053 GO:0046883 GO:0014062 GO:0042428 GO:0007210 GO:0042310
InterPro	IPR000610 IPR002231 IPR000276 IPR017452
PANTHER	PTHR24247:SF20
Pfam	PF00001
PRINTS	PR00512 PR01101 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
NOT	GO:0007616	long-term memory	PMID:12562581^[1]	ECO:0000269			P		Figure 1 Discussion: "It appears evident that the activity of postsynaptic 5-HT1A receptors in the hippocampus has an inhibitory influence on human explicit memory function." (Paragraph 3)	complete
enables	GO:0090722	receptor-receptor interaction	PMID:24157794^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P11362) has_direct_input:(CHEBI:73364)	Seeded From UniProt	complete
involved_in	GO:0042428	serotonin metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
involved_in	GO:0042053	regulation of dopamine metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
involved_in	GO:0035640	exploration behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
involved_in	GO:0014062	regulation of serotonin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
involved_in	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
involved_in	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	PMID:8393041^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:22957663^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:22957663^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:22957663^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:8393041^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001662	behavioral fear response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002385064 RGD:2845 RGD:62388	F		Seeded From UniProt	complete
enables	GO:0030594	neurotransmitter receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:71034	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2342 RGD:2343 RGD:2518 RGD:2522 RGD:2851 RGD:61800 RGD:61801 RGD:620023 RGD:62044 RGD:71034	C		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2830 RGD:2846	P		Seeded From UniProt	complete
involved_in	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002385064 RGD:2845 UniProtKB:P08908	P		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2851 RGD:62044	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000037 PANTHER:PTN000664111 RGD:2343 UniProtKB:P08172 UniProtKB:P08908 UniProtKB:P21917 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30546 UniProtKB:P30939 WB:WBGene00001519	C		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004168 FB:FBgn0004573 FB:FBgn0087012 FB:FBgn0263116 MGI:MGI:109323 MGI:MGI:96273 MGI:MGI:96274 MGI:MGI:96276 MGI:MGI:96281 MGI:MGI:96284 PANTHER:PTN000664111 RGD:2845 RGD:2846 RGD:2848 RGD:2850 RGD:2851 RGD:61800 RGD:62044 RGD:62388 RGD:71034 UniProtKB:A0A0B4KFU6 UniProtKB:P08908 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28223 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30939 UniProtKB:P41595 UniProtKB:P47898 UniProtKB:Q13639 WB:WBGene00004776 WB:WBGene00004779	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2518	F		Seeded From UniProt	complete
involved_in	GO:0042428	serotonin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64264 ensembl:ENSMUSP00000022235	P		Seeded From UniProt	complete
involved_in	GO:0042053	regulation of dopamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64264 ensembl:ENSMUSP00000022235	P		Seeded From UniProt	complete
involved_in	GO:0035640	exploration behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64264 ensembl:ENSMUSP00000022235	P		Seeded From UniProt	complete
involved_in	GO:0014062	regulation of serotonin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64264 ensembl:ENSMUSP00000022235	P		Seeded From UniProt	complete
involved_in	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64264 ensembl:ENSMUSP00000022235	P		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64264 ensembl:ENSMUSP00000022235	F		Seeded From UniProt	complete
involved_in	GO:0001662	behavioral fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64264 ensembl:ENSMUSP00000022235	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610 InterPro:IPR002231	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610 InterPro:IPR002231	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000610 InterPro:IPR002231	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610	P		Seeded From UniProt	complete
involved_in	GO:0046883	regulation of hormone secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610	P		Seeded From UniProt	complete
involved_in	GO:0050795	regulation of behavior	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:1330092^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:1330092^[6] Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:3138543^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:9736659^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-390929 Reactome:R-HSA-380073	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
involved_in	GO:0007610	behavior	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0085	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yasuno, F et al. (2003) Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory. Am J Psychiatry 160 334-40 PubMed GONUTS page
↑ Borroto-Escuela, DO et al. (2013) Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2. Biochem. Biophys. Res. Commun. 441 387-92 PubMed GONUTS page
↑ ^3.0 ^3.1 Aune, TM et al. (1993) Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine. J. Immunol. 151 1175-83 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Singh, P et al. (2012) Role of glycosphingolipids in the function of human serotonin₁A receptors. J. Neurochem. 123 716-24 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Varrault, A et al. (1992) Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis. Mol. Biol. Cell 3 961-9 PubMed GONUTS page
↑ Fargin, A et al. (1988) The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature 335 358-60 PubMed GONUTS page
↑ Stockmeier, CA et al. (1998) Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J. Neurosci. 18 7394-401 PubMed GONUTS page

[PMID:12562581-1] Yasuno, F et al. (2003) Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory. Am J Psychiatry 160 334-40 PubMed GONUTS page

[PMID:24157794-2] Borroto-Escuela, DO et al. (2013) Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2. Biochem. Biophys. Res. Commun. 441 387-92 PubMed GONUTS page

[PMID:8393041-3] 3.0 ^3.1 Aune, TM et al. (1993) Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine. J. Immunol. 151 1175-83 PubMed GONUTS page

[PMID:22957663-4] 4.0 ^4.1 ^4.2 Singh, P et al. (2012) Role of glycosphingolipids in the function of human serotonin₁A receptors. J. Neurochem. 123 716-24 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1330092-6] 6.0 ^6.1 Varrault, A et al. (1992) Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis. Mol. Biol. Cell 3 961-9 PubMed GONUTS page

[PMID:3138543-7] Fargin, A et al. (1988) The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature 335 358-60 PubMed GONUTS page

[PMID:9736659-8] Stockmeier, CA et al. (1998) Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J. Neurosci. 18 7394-401 PubMed GONUTS page

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HUMAN:5HT1A

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Annotations

Notes

References

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