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HELPY:HMCT
Contents
| Species (Taxon ID) | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori). (85962) | |
| Gene Name(s) | cadA | |
| Protein Name(s) | Cadmium, zinc and cobalt-transporting ATPase | |
| External Links | ||
| UniProt | Q59465 | |
| EMBL | L46864 AE000511 | |
| PIR | G64618 | |
| RefSeq | NP_207584.1 YP_006934705.1 | |
| ProteinModelPortal | Q59465 | |
| DIP | DIP-3082N | |
| IntAct | Q59465 | |
| MINT | MINT-188226 | |
| STRING | 85962.HP0791 | |
| TCDB | 3.A.3.6.3 | |
| PRIDE | Q59465 | |
| DNASU | 899347 | |
| EnsemblBacteria | AAD07839 | |
| GeneID | 13869974 899347 | |
| KEGG | heo:C694_04055 hpy:HP0791 | |
| PATRIC | 20592869 | |
| eggNOG | COG2217 | |
| KO | K01534 | |
| OMA | EKAMFFV | |
| OrthoDB | EOG6742RM | |
| BioCyc | HPY:HP0791-MONOMER | |
| Proteomes | UP000000429 | |
| GO | GO:0016021 GO:0005886 GO:0005524 GO:0008551 GO:0046872 GO:0016463 GO:0030001 | |
| Gene3D | 2.70.150.10 3.40.1110.10 3.40.50.1000 | |
| InterPro | IPR023299 IPR018303 IPR008250 IPR023214 IPR017969 IPR006121 IPR027256 IPR001757 | |
| Pfam | PF00122 PF00403 PF00702 | |
| PRINTS | PR00119 PR00941 | |
| SUPFAM | SSF55008 SSF56784 | |
| TIGRFAMs | TIGR01525 TIGR01494 | |
| PROSITE | PS00154 PS01047 PS50846 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0030001 |
metal ion transport |
ECO:0000315 |
P |
Table 1: Growth of all four cadA mutants was at least 10- fold more sensitive to cadmium and zinc compared with the parental strain. This phenotype could be reversed by the H. pylori CadA expression vector pY178, as demonstrated for H. pylori 439-3[py178] and 13-9[pY178]. Additionally, strains harbouring plasmid pY178 grew in 10-fold to 20-fold higher concentrations of cobalt than the control strains. The increase in cobalt resistance corresponds to the elevated CadA protein content of strains carrying pY178. This evidence suggests that CadA is involved in the transport of these metal ions. |
complete | |||||
|
involved_in |
GO:0030001 |
metal ion transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015086 |
cadmium ion transmembrane transporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000644029 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005385 |
zinc ion transmembrane transporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000644029 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070574 |
cadmium ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0015086 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070574 |
cadmium ion transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008551 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071577 |
zinc ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005385 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099132 |
ATP hydrolysis coupled cation transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0019829 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099132 |
ATP hydrolysis coupled cation transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008551 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006812 |
cation transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019829 |
cation-transporting ATPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030001 |
metal ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008551 |
cadmium-exporting ATPase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Herrmann, L et al. (1999) Helicobacter pylori cadA encodes an essential Cd(II)-Zn(II)-Co(II) resistance factor influencing urease activity. Mol. Microbiol. 33 524-36 PubMed GONUTS page
- ↑ 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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