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HELPY:HCPA

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Species (Taxon ID) Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori). (85962)
Gene Name(s) hcpA
Protein Name(s) Beta-lactamase HcpA

Cysteine-rich 28 kDa protein

External Links
UniProt O25001
EMBL AF008565
AF053708
AE000511
PIR C64546
RefSeq NP_207009.1
YP_006934136.1
ProteinModelPortal O25001
SMR O25001
STRING 85962.HP0211
PRIDE O25001
EnsemblBacteria AAD07279
GeneID 13869392
899162
KEGG heo:C694_01060
hpy:HP0211
PATRIC 20591645
eggNOG COG0790
KO K07126
OMA THFEKAC
OrthoDB EOG6TJ7WZ
BioCyc HPY:HP0211-MONOMER
Proteomes UP000000429
GO GO:0005576
GO:0008800
GO:0008152
GO:0046677
Gene3D 1.25.40.10
InterPro IPR006597
IPR011990
IPR013105
Pfam PF08238
PF07719
SMART SM00671

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008800

beta-lactamase activity

PMID:10748053[1]

ECO:0000314

F

Table 2: Purified HcpA demonstrates the ability to hydrolyze several beta-lactam antibiotics.

complete
CACAO 6183

enables

GO:0008800

beta-lactamase activity

PMID:10748053[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008047

enzyme activator activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002462320
SGD:S000000898

F

Seeded From UniProt

complete

involved_in

GO:0043085

positive regulation of catalytic activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008047

P

Seeded From UniProt

complete

enables

GO:0008800

beta-lactamase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.2.6

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0046

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Mittl, PR et al. (2000) The cysteine-rich protein A from Helicobacter pylori is a beta-lactamase. J. Biol. Chem. 275 17693-9 PubMed GONUTS page
  2. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page