HELPX:HAP

Species (Taxon ID)	Helicobacter pylori (Campylobacter pylori). (210)
Gene Name(s)	hap
Protein Name(s)	Zinc metalloprotease
External Links
UniProt	Q48259
EMBL	Z27239
PIR	S54406
ProteinModelPortal	Q48259
SMR	Q48259
MEROPS	M04.003
GO	GO:0005576 GO:0004222
InterPro	IPR007280 IPR023612 IPR001570
Pfam	PF02868 PF04151
PRINTS	PR00730

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008237	metallopeptidase activity	PMID:9234765	ECO:0000314			F		FIG. 7, shows activity level of metalloprotease in mediums of various concentrations of zinc chloride, divalent cations, and temperature. Secreted by H. pylori.	complete
	GO:0005576	extracellular region	PMID:9234765	ECO:0000314			C		Fig. 8A, Protease obtained by gently washing fresh metalloproteases and centrifuging them to obtain the protease from the supernatant. The activity of the protease were inhibited as the concentration of 1mM Ca2+ and 0.1mM Zn2+, yet it was more inhibited when zinc was absent from the medium.	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001570 InterPro:IPR023612	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023612	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
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References

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