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HELP3:D7FF05

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Species (Taxon ID) Helicobacter pylori (strain B8). (693745)
Gene Name(s) tlyA (ECO:0000313 with EMBL:CBI66762.1)
Protein Name(s) Hemolysin (Tly) (ECO:0000313 with EMBL:CBI66762.1)
External Links
UniProt D7FF05
EMBL FN598874
RefSeq WP_001235221.1
YP_003729226.1
ProteinModelPortal D7FF05
EnsemblBacteria CBI66762
GeneID 9348766
KEGG hpl:HPB8_1205
PATRIC 38176713
HOGENOM HOG000009215
KO K06442
OMA QVLVNKM
BioCyc HPYL693745:GJAE-1226-MONOMER
Proteomes UP000007091
GO GO:0008168
GO:0003723
Gene3D 3.10.290.10
3.40.50.150
InterPro IPR004538
IPR002877
IPR002942
IPR029063
Pfam PF01728
PF01479
SMART SM00363
SUPFAM SSF53335
TIGRFAMs TIGR00478
PROSITE PS50889

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0019836

hemolysis by symbiont of host erythrocytes

PMID:24434145[1]

ECO:0000314

P

Figure 3A: Purified TlyA displayed concentration-dependent hemolytic activity against human erythrocytes. The higher the concentration of TlyA added, the higher the percentage of hemolysis.

complete
CACAO 9719

involved_in

GO:0019836

hemolysis by symbiont of host erythrocytes

PMID:24434145[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002942
InterPro:IPR004538
InterPro:IPR036986

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002877

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002877

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Lata, K et al. (2014) Functional characterization of Helicobacter pylori TlyA: pore-forming hemolytic activity and cytotoxic property of the protein. Biochem. Biophys. Res. Commun. 444 153-7 PubMed GONUTS page