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FELCA:GHRL

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Species (Taxon ID) Felis catus (Cat) (Felis silvestris catus). (9685)
Gene Name(s) GHRL
Protein Name(s) Appetite-regulating hormone

Growth hormone secretagogue Growth hormone-releasing peptide Motilin-related peptide Ghrelin Obestatin

External Links
UniProt Q6BEG6
EMBL AB089201
AB089202
RefSeq NP_001009853.1
GeneID 493844
KEGG fca:493844
CTD 51738
eggNOG NOG45924
HOGENOM HOG000236303
HOVERGEN HBG018522
InParanoid Q6BEG6
KO K05254
TreeFam TF336219
Proteomes UP000011712
GO GO:0030424
GO:0005737
GO:0005615
GO:0031768
GO:0016608
GO:0005179
GO:0030296
GO:0008154
GO:0000187
GO:0008343
GO:0046697
GO:0016358
GO:0043066
GO:0042322
GO:0001937
GO:0050728
GO:0046676
GO:0032691
GO:0045409
GO:0040013
GO:0042536
GO:0032100
GO:0046010
GO:0051461
GO:0051464
GO:0007204
GO:0060124
GO:0032024
GO:0032097
GO:0051965
GO:0060079
GO:0032095
GO:0043627
InterPro IPR006737
IPR006738
IPR005441
PANTHER PTHR14122
Pfam PF04643
PF04644
PRINTS PR01624

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051965

positive regulation of synapse assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UBU3

P

Seeded From UniProt

complete

involved_in

GO:0046676

negative regulation of insulin secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QYH7

P

Seeded From UniProt

complete

involved_in

GO:0032097

positive regulation of response to food

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QYH7

P

Seeded From UniProt

complete

involved_in

GO:0032095

regulation of response to food

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QYH7

P

Seeded From UniProt

complete

involved_in

GO:0032024

positive regulation of insulin secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QYH7

P

Seeded From UniProt

complete

enables

GO:0031768

ghrelin receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QYH7

F

Seeded From UniProt

complete

enables

GO:0016608

growth hormone-releasing hormone activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QYH7

F

Seeded From UniProt

complete

involved_in

GO:0016358

dendrite development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UBU3

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QYH7

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QYH7

F

Seeded From UniProt

complete

involved_in

GO:0060124

positive regulation of growth hormone secretion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000364583
RGD:632283
UniProtKB:Q9UBU3

P

Seeded From UniProt

complete

involved_in

GO:0050728

negative regulation of inflammatory response

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000364583
UniProtKB:Q9UBU3

P

Seeded From UniProt

complete

involved_in

GO:0032095

regulation of response to food

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000364583
RGD:632283

P

Seeded From UniProt

complete

enables

GO:0031768

ghrelin receptor binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000364583
RGD:632283
UniProtKB:Q8AV73

F

Seeded From UniProt

complete

enables

GO:0016608

growth hormone-releasing hormone activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000364583
RGD:632283

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000364583
UniProtKB:Q8AV73
UniProtKB:Q9GKY5
UniProtKB:Q9UBU3

C

Seeded From UniProt

complete

involved_in

GO:0001696

gastric acid secretion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000364583
RGD:632283

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016608

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016608

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0061098

positive regulation of protein tyrosine kinase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0030296

P

Seeded From UniProt

complete

part_of

GO:0098794

postsynapse

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0060079

C

Seeded From UniProt

complete

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EQX0
ensembl:ENSMUSP00000145281

P

Seeded From UniProt

complete

involved_in

GO:0060079

excitatory postsynaptic potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EQX0
ensembl:ENSMUSP00000145281

P

Seeded From UniProt

complete

involved_in

GO:0051965

positive regulation of synapse assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EQX0
ensembl:ENSMUSP00000145281

P

Seeded From UniProt

complete

involved_in

GO:0046676

negative regulation of insulin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EQX0
ensembl:ENSMUSP00000145281

P

Seeded From UniProt

complete

involved_in

GO:0040013

negative regulation of locomotion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EQX0
ensembl:ENSMUSP00000145281

P

Seeded From UniProt

complete

involved_in

GO:0032100

positive regulation of appetite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EQX0
ensembl:ENSMUSP00000145281

P

Seeded From UniProt

complete

involved_in

GO:0016358

dendrite development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EQX0
ensembl:ENSMUSP00000145281

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EQX0
ensembl:ENSMUSP00000145281

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EQX0
ensembl:ENSMUSP00000145281

C

Seeded From UniProt

complete

involved_in

GO:0060124

positive regulation of growth hormone secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0051965

positive regulation of synapse assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0051464

positive regulation of cortisol secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0051461

positive regulation of corticotropin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0050728

negative regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0046697

decidualization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0046010

positive regulation of circadian sleep/wake cycle, non-REM sleep

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0045409

negative regulation of interleukin-6 biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0043627

response to estrogen

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0042536

negative regulation of tumor necrosis factor biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0042322

negative regulation of circadian sleep/wake cycle, REM sleep

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0032691

negative regulation of interleukin-1 beta production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

C

Seeded From UniProt

complete

enables

GO:0030296

protein tyrosine kinase activator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

F

Seeded From UniProt

complete

involved_in

GO:0016358

dendrite development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0009725

response to hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0008154

actin polymerization or depolymerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

C

Seeded From UniProt

complete

involved_in

GO:0001937

negative regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

involved_in

GO:0000187

activation of MAPK activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBU3
ensembl:ENSP00000335074

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006737
InterPro:IPR006738

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005441
InterPro:IPR006737
InterPro:IPR006738

C

Seeded From UniProt

complete

enables

GO:0016608

growth hormone-releasing hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005441

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page