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FB:fng

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Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) fng ( synonyms: CG10580, D-Fng, D-fng, Dfng, Fng, Frg, Fringe, fg, frg, l(3)rG554 )
Protein Name(s) fringe,
External Links
FB FBgn0011591

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001708

cell fate specification

FB:FBrf0160750
PMID:12879448[1]

NAS: Non-traceable Author Statement

P

From FB

GO:0001745

compound eye morphogenesis

FB:FBrf0167947
PMID:14702038[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0005783

endoplasmic reticulum

FB:FBrf0138491
PMID:11514618[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0005794

Golgi apparatus

FB:FBrf0124302

NAS: Non-traceable Author Statement

C

From FB

GO:0005794

Golgi apparatus

FB:FBrf0128582
PMID:10899003[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005794

Golgi apparatus

FB:FBrf0160750
PMID:12879448[1]

TAS: Traceable Author Statement

C

From FB

GO:0005795

Golgi stack

FB:FBrf0138491
PMID:11514618[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0005797

Golgi medial cisterna

FB:FBrf0217862
PMID:22251795[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0006004

fucose metabolic process

FB:FBrf0129976
PMID:10935626[6]

IDA: Inferred from Direct Assay

P

From FB

GO:0006004

fucose metabolic process

FB:FBrf0206826
PMID:18725413[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006493

protein O-linked glycosylation

FB:FBrf0206826
PMID:18725413[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007219

Notch signaling pathway

FB:FBrf0129976
PMID:10935626[6]

IDA: Inferred from Direct Assay

P

From FB

GO:0007219

Notch signaling pathway

FB:FBrf0137174
PMID:11494317[8]

TAS: Traceable Author Statement

P

From FB

GO:0007293

germarium-derived egg chamber formation

FB:FBrf0130273
PMID:11034906[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007293

germarium-derived egg chamber formation

FB:FBrf0137222
PMID:11493544[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007450

dorsal/ventral pattern formation, imaginal disc

FB:FBrf0083225
PMID:7671307[11]

IDA: Inferred from Direct Assay

P

From FB

GO:0007451

dorsal/ventral lineage restriction, imaginal disc

FB:FBrf0141064
PMID:11253649[12]

TAS: Traceable Author Statement

P

From FB

GO:0007476

imaginal disc-derived wing morphogenesis

FB:FBrf0076041
PMID:7954826[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007476

imaginal disc-derived wing morphogenesis

FB:FBrf0083225
PMID:7671307[11]

IDA: Inferred from Direct Assay

P

From FB

GO:0008194

UDP-glycosyltransferase activity

FB:FBrf0129976
PMID:10935626[6]

IDA: Inferred from Direct Assay

F

From FB

GO:0008375

acetylglucosaminyltransferase activity

FB:FBrf0124302

NAS: Non-traceable Author Statement

F

From FB

GO:0008375

acetylglucosaminyltransferase activity

FB:FBrf0129976
PMID:10935626[6]

IDA: Inferred from Direct Assay

F

From FB

GO:0008375

acetylglucosaminyltransferase activity

FB:FBrf0149064
PMID:12070132[14]

TAS: Traceable Author Statement

F

From FB

GO:0008375

acetylglucosaminyltransferase activity

FB:FBrf0152092
PMID:12130651[15]

TAS: Traceable Author Statement

F

From FB

GO:0008375

acetylglucosaminyltransferase activity

FB:FBrf0155642
PMID:12464307[16]

TAS: Traceable Author Statement

F

From FB

GO:0008587

imaginal disc-derived wing margin morphogenesis

FB:FBrf0076041
PMID:7954826[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008593

regulation of Notch signaling pathway

FB:FBrf0137222
PMID:11493544[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008593

regulation of Notch signaling pathway

FB:FBrf0141064
PMID:11253649[12]

TAS: Traceable Author Statement

P

From FB

GO:0008593

regulation of Notch signaling pathway

FB:FBrf0149064
PMID:12070132[14]

TAS: Traceable Author Statement

P

From FB

GO:0008593

regulation of Notch signaling pathway

FB:FBrf0151490
PMID:12127141[17]

TAS: Traceable Author Statement

P

From FB

GO:0008593

regulation of Notch signaling pathway

FB:FBrf0152092
PMID:12130651[15]

NAS: Non-traceable Author Statement

P

From FB

GO:0008593

regulation of Notch signaling pathway

FB:FBrf0202801
PMID:17923477[18]

IDA: Inferred from Direct Assay

P

From FB

GO:0016021

integral to membrane

FB:FBrf0124302

NAS: Non-traceable Author Statement

C

From FB

GO:0030173

integral to Golgi membrane

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR017374

C

From FB

GO:0033829

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

FB:FBrf0202801
PMID:17923477[18]

IDA: Inferred from Direct Assay

F

From FB

GO:0035017

cuticle pattern formation

FB:FBrf0190179
PMID:16125166[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035017

cuticle pattern formation

FB:FBrf0200191
PMID:16890930[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0036011

imaginal disc-derived leg segmentation

FB:FBrf0109019
PMID:10357895[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045746

negative regulation of Notch signaling pathway

FB:FBrf0151870
PMID:12419199[22]

NAS: Non-traceable Author Statement

P

From FB

GO:0045747

positive regulation of Notch signaling pathway

FB:FBrf0124302

NAS: Non-traceable Author Statement

P

From FB

GO:0048190

wing disc dorsal/ventral pattern formation

FB:FBrf0202749
PMID:18202376[23]

IGI: Inferred from Genetic Interaction

FB:FBgn0000242
FB:FBgn0000099

P

From FB

GO:0048477

oogenesis

FB:FBrf0160750
PMID:12879448[1]

TAS: Traceable Author Statement

P

From FB

GO:0048749

compound eye development

FB:FBrf0105420
PMID:9834035[24]

IDA: Inferred from Direct Assay

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 López-Schier, H (2003) The polarisation of the anteroposterior axis in Drosophila. Bioessays 25 781-91 PubMed GONUTS page
  2. Dominguez, M et al. (2004) Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster. Nat. Genet. 36 31-9 PubMed GONUTS page
  3. 3.0 3.1 Kondylis, V et al. (2001) Biogenesis of Golgi stacks in imaginal discs of Drosophila melanogaster. Mol. Biol. Cell 12 2308-27 PubMed GONUTS page
  4. Munro, S & Freeman, M (2000) The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. Curr. Biol. 10 813-20 PubMed GONUTS page
  5. Yamamoto-Hino, M et al. (2012) Cisterna-specific localization of glycosylation-related proteins to the Golgi apparatus. Cell Struct. Funct. 37 55-63 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Moloney, DJ et al. (2000) Fringe is a glycosyltransferase that modifies Notch. Nature 406 369-75 PubMed GONUTS page
  7. 7.0 7.1 Aoki, K et al. (2008) The diversity of O-linked glycans expressed during Drosophila melanogaster development reflects stage- and tissue-specific requirements for cell signaling. J. Biol. Chem. 283 30385-400 PubMed GONUTS page
  8. Gibson, MC & Schubiger, G (2001) Drosophila peripodial cells, more than meets the eye? Bioessays 23 691-7 PubMed GONUTS page
  9. Zhao, D et al. (2000) Expression of fringe is down regulated by Gurken/Epidermal Growth Factor Receptor signalling and is required for the morphogenesis of ovarian follicle cells. J. Cell. Sci. 113 Pt 21 3781-94 PubMed GONUTS page
  10. 10.0 10.1 Grammont, M & Irvine, KD (2001) fringe and Notch specify polar cell fate during Drosophila oogenesis. Development 128 2243-53 PubMed GONUTS page
  11. 11.0 11.1 Kim, J et al. (1995) Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell 82 795-802 PubMed GONUTS page
  12. 12.0 12.1 McNeill, H (2000) Sticking together and sorting things out: adhesion as a force in development. Nat. Rev. Genet. 1 100-8 PubMed GONUTS page
  13. 13.0 13.1 Irvine, KD & Wieschaus, E (1994) fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell 79 595-606 PubMed GONUTS page
  14. 14.0 14.1 Muller, JM et al. (2002) Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. J. Cell Biol. 157 1161-73 PubMed GONUTS page
  15. 15.0 15.1 Schwientek, T et al. (2002) The Drosophila gene brainiac encodes a glycosyltransferase putatively involved in glycosphingolipid synthesis. J. Biol. Chem. 277 32421-9 PubMed GONUTS page
  16. Wilson, IB (2002) Glycosylation of proteins in plants and invertebrates. Curr. Opin. Struct. Biol. 12 569-77 PubMed GONUTS page
  17. Stewart, BA (2002) Membrane trafficking in Drosophila wing and eye development. Semin. Cell Dev. Biol. 13 91-7 PubMed GONUTS page
  18. 18.0 18.1 Xu, A et al. (2007) In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe. J. Biol. Chem. 282 35153-62 PubMed GONUTS page
  19. Walters, JW et al. (2005) Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation. Dev. Biol. 286 415-26 PubMed GONUTS page
  20. Walters, JW et al. (2006) Planar polarization of the denticle field in the Drosophila embryo: roles for Myosin II (zipper) and fringe. Dev. Biol. 297 323-39 PubMed GONUTS page
  21. Rauskolb, C & Irvine, KD (1999) Notch-mediated segmentation and growth control of the Drosophila leg. Dev. Biol. 210 339-50 PubMed GONUTS page
  22. Lai, EC (2002) Developmental signaling: shrimp and strawberries help flies make cones. Curr. Biol. 12 R722-4 PubMed GONUTS page
  23. Bejarano, F et al. (2008) A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. Genetics 178 307-23 PubMed GONUTS page
  24. Domínguez, M & de Celis, JF (1998) A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature 396 276-8 PubMed GONUTS page
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