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ECOLX:K3K3U9

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Species (Taxon ID) Escherichia coli N1. (1005567)
Gene Name(s) folA (ECO:0000313 with EMBL:EKI56005.1)
Protein Name(s) Dihydrofolate reductase (ECO:0000256 with PIRNR:PIRNR000194)
External Links
UniProt K3K3U9
EMBL AMUQ01000011
RefSeq WP_000624375.1
ProteinModelPortal K3K3U9
SMR K3K3U9
BindingDB K3K3U9
EnsemblBacteria EKI56005
OMA MCITHVE
UniPathway UPA00077
Proteomes UP000007354
GO GO:0004146
GO:0050661
GO:0006545
GO:0009165
GO:0006730
GO:0046654
Gene3D 3.40.430.10
InterPro IPR012259
IPR024072
IPR017925
IPR001796
Pfam PF00186
PIRSF PIRSF000194
PRINTS PR00070
SUPFAM SSF53597
PROSITE PS00075
PS51330

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004146

dihydrofolate reductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001796
InterPro:IPR012259
InterPro:IPR017925

F

Seeded From UniProt

GO:0004146

dihydrofolate reductase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.5.1.3

F

Seeded From UniProt

GO:0006545

glycine biosynthetic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001796
InterPro:IPR012259

P

Seeded From UniProt

GO:0006730

one-carbon metabolic process

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0554

P

Seeded From UniProt

GO:0009165

nucleotide biosynthetic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001796
InterPro:IPR012259

P

Seeded From UniProt

GO:0016491

oxidoreductase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

Seeded From UniProt

GO:0046654

tetrahydrofolate biosynthetic process

GO_REF:0000041

IEA: Inferred from Electronic Annotation

UniPathway:UPA00077

P

Seeded From UniProt

GO:0050661

NADP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012259

F

Seeded From UniProt

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001796
InterPro:IPR012259
InterPro:IPR017925

P

Seeded From UniProt

GO:0055114

oxidation-reduction process

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

P

Seeded From UniProt

GO:0004146

dihydrofolate reductase activity

GO_REF:0000002

ISA: Inferred from Sequence Alignment

PMID:26147643[1] UniProtKB:P0ABQ4


F

Blastp results showed 100.0% sequence similarity, with an E-value of 1.1E-114.

complete
CACAO 11852

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Oyen, D et al. (2015) Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway. J. Am. Chem. Soc. 137 9459-68 PubMed GONUTS page