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ECOLI:TYSY
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | thyA (ECO:0000255 with HAMAP-Rule:MF_00008) | |
| Protein Name(s) | Thymidylate synthase (ECO:0000255 with HAMAP-Rule:MF_00008)
TS (ECO:0000255 with HAMAP-Rule:MF_00008) TSase (ECO:0000255 with HAMAP-Rule:MF_00008) | |
| External Links | ||
| UniProt | P0A884 | |
| EMBL | J01710 U29581 U00096 AP009048 X03966 | |
| PIR | A00549 | |
| RefSeq | NP_417304.1 YP_491032.1 | |
| PDB | 1AIQ 1AJM 1AN5 1AOB 1AXW 1BDU 1BID 1BJG 1BQ1 1BQ2 1DDU 1DNA 1EV5 1EV8 1EVF 1EVG 1F4B 1F4C 1F4D 1F4E 1F4F 1F4G 1FFL 1FWM 1JG0 1JTQ 1JTU 1JUT 1KCE 1KZI 1KZJ 1NCE 1QQQ 1SYN 1TDU 1TJS 1TLC 1TLS 1TRG 1TSD 1TSN 1TYS 1ZPR 2A9W 2BBQ 2FTN 2FTO 2FTQ 2G8X 2KCE 2TSC 2VET 2VF0 3B5B 3B9H 3BFI 3BGX 3BHL 3BHR 3TMS 4F2V 4GEV 4ISK 4KNZ | |
| PDBsum | 1AIQ 1AJM 1AN5 1AOB 1AXW 1BDU 1BID 1BJG 1BQ1 1BQ2 1DDU 1DNA 1EV5 1EV8 1EVF 1EVG 1F4B 1F4C 1F4D 1F4E 1F4F 1F4G 1FFL 1FWM 1JG0 1JTQ 1JTU 1JUT 1KCE 1KZI 1KZJ 1NCE 1QQQ 1SYN 1TDU 1TJS 1TLC 1TLS 1TRG 1TSD 1TSN 1TYS 1ZPR 2A9W 2BBQ 2FTN 2FTO 2FTQ 2G8X 2KCE 2TSC 2VET 2VF0 3B5B 3B9H 3BFI 3BGX 3BHL 3BHR 3TMS 4F2V 4GEV 4ISK 4KNZ | |
| ProteinModelPortal | P0A884 | |
| SMR | P0A884 | |
| DIP | DIP-48261N | |
| IntAct | P0A884 | |
| MINT | MINT-1265510 | |
| STRING | 511145.b2827 | |
| BindingDB | P0A884 | |
| ChEMBL | CHEMBL2555 | |
| PaxDb | P0A884 | |
| PRIDE | P0A884 | |
| EnsemblBacteria | AAC75866 BAE76896 | |
| GeneID | 12933064 949035 | |
| KEGG | ecj:Y75_p2761 eco:b2827 | |
| PATRIC | 32121072 | |
| EchoBASE | EB0995 | |
| EcoGene | EG11002 | |
| eggNOG | COG0207 | |
| HOGENOM | HOG000257900 | |
| InParanoid | P0A884 | |
| KO | K00560 | |
| OMA | NEWADEN | |
| OrthoDB | EOG6K6V53 | |
| PhylomeDB | P0A884 | |
| BioCyc | EcoCyc:THYMIDYLATESYN-MONOMER ECOL316407:JW2795-MONOMER MetaCyc:THYMIDYLATESYN-MONOMER | |
| SABIO-RK | P0A884 | |
| UniPathway | UPA00575 | |
| EvolutionaryTrace | P0A884 | |
| PRO | PR:P0A884 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P0A884 | |
| GO | GO:0005737 GO:0003723 GO:0004799 GO:0006231 GO:0006235 GO:0006417 | |
| Gene3D | 3.30.572.10 | |
| HAMAP | MF_00008 | |
| InterPro | IPR023451 IPR000398 IPR020940 | |
| Pfam | PF00303 | |
| PRINTS | PR00108 | |
| SUPFAM | SSF55831 | |
| TIGRFAMs | TIGR03284 | |
| PROSITE | PS00091 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006231 |
dTMP biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11002 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11002 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11002 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009314 |
response to radiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006231 |
dTMP biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006231 |
dTMP biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000074698 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006231 |
dTMP biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000074698 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004799 |
thymidylate synthase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000074698 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009165 |
nucleotide biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006417 |
regulation of translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006235 |
dTTP biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00575 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Sargentini, NJ et al. () Screen for genes involved in radiation survival of Escherichia coli and construction of a reference database. Mutat. Res. 793-794 1-14 PubMed GONUTS page
- ↑ 3.0 3.1 Haertlé, T et al. (1979) Thymidylate synthetase from Escherichia coli K12. Purification, and dependence of kinetic properties on sugar conformation and size of the 2' substituent. Eur. J. Biochem. 102 223-30 PubMed GONUTS page
- ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
- ↑ Belfort, M et al. (1983) Characterization of the Escherichia coli thyA gene and its amplified thymidylate synthetase product. Proc. Natl. Acad. Sci. U.S.A. 80 1858-61 PubMed GONUTS page
- ↑ Wang, Z et al. (2013) Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J. Am. Chem. Soc. 135 7583-92 PubMed GONUTS page
