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ECOLI:TRMH

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) trmH (synonyms: spoU)
Protein Name(s) tRNA (guanosine(18)-2'-O)-methyltransferase

tRNA [Gm18] methyltransferase

External Links
UniProt P0AGJ2
EMBL M24503
L10328
U00096
AP009048
PIR JV0043
RefSeq NP_418108.1
YP_491783.1
ProteinModelPortal P0AGJ2
SMR P0AGJ2
DIP DIP-35977N
IntAct P0AGJ2
STRING 511145.b3651
PaxDb P0AGJ2
PRIDE P0AGJ2
EnsemblBacteria AAC76675
BAE77642
GeneID 12933575
948161
KEGG ecj:Y75_p3523
eco:b3651
PATRIC 32122789
EchoBASE EB0960
EcoGene EG10967
eggNOG COG0566
HOGENOM HOG000285175
InParanoid P0AGJ2
KO K00556
OMA VHAVWPT
OrthoDB EOG6GBMDM
PhylomeDB P0AGJ2
BioCyc EcoCyc:EG10967-MONOMER
ECOL316407:JW3626-MONOMER
MetaCyc:EG10967-MONOMER
PRO PR:P0AGJ2
Proteomes UP000000318
UP000000625
Genevestigator P0AGJ2
GO GO:0005737
GO:0003723
GO:0009020
GO:0002938
GO:0030488
Gene3D 3.40.1280.10
InterPro IPR029028
IPR022724
IPR001537
IPR029026
Pfam PF12105
PF00588
SUPFAM SSF75217

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0009020

tRNA (guanosine-2'-O-)-methyltransferase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10967
PANTHER:PTN000947837
UniProtKB:O67577

F

Seeded From UniProt

complete

involved_in

GO:0002938

tRNA guanine ribose methylation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10967
PANTHER:PTN000947837
UniProtKB:O67577

P

Seeded From UniProt

complete

enables

GO:0009020

tRNA (guanosine-2'-O-)-methyltransferase activity

PMID:9321663[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0009020

tRNA (guanosine-2'-O-)-methyltransferase activity

PMID:23867454[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0002938

tRNA guanine ribose methylation

PMID:9321663[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001537

F

Seeded From UniProt

complete

involved_in

GO:0006396

RNA processing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001537

P

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033671

F

Seeded From UniProt

complete

enables

GO:0008173

RNA methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001537

F

Seeded From UniProt

complete

enables

GO:0009020

tRNA (guanosine-2'-O-)-methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022724

F

Seeded From UniProt

complete

involved_in

GO:0030488

tRNA methylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033671

P

Seeded From UniProt

complete

enables

GO:0009020

tRNA (guanosine-2'-O-)-methyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.34

F

Seeded From UniProt

complete

enables

GO:0000049

tRNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000293450

F

Seeded From UniProt

complete

involved_in

GO:0002938

tRNA guanine ribose methylation

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000293450

P

Seeded From UniProt

complete

enables

GO:0009020

tRNA (guanosine-2'-O-)-methyltransferase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000293450

F

Seeded From UniProt

complete

involved_in

GO:0030488

tRNA methylation

PMID:9321663[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

involved_in

GO:0008033

tRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0819

P

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0000049

tRNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0820

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 Persson, BC et al. (1997) The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity. Nucleic Acids Res. 25 4093-7 PubMed GONUTS page
  3. Ochi, A et al. (2013) The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process. J. Biol. Chem. 288 25562-74 PubMed GONUTS page