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ECOLI:TOLC

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) tolC (synonyms: colE1-i, mtcB, mukA, refI, toc, weeA)
Protein Name(s) Outer membrane protein TolC

Multidrug efflux pump subunit TolC Outer membrane factor TolC

External Links
UniProt P02930
EMBL X00016
X54049
U28377
U00096
AP009048
V01505
PIR A65091
RefSeq NP_417507.2
YP_491227.1
PDB 1EK9
1TQQ
2VDD
2VDE
2WMZ
2XMN
PDBsum 1EK9
1TQQ
2VDD
2VDE
2WMZ
2XMN
ProteinModelPortal P02930
SMR P02930
DIP DIP-11007N
IntAct P02930
STRING 511145.b3035
TCDB 1.B.17.1.1
SWISS-2DPAGE P02930
PaxDb P02930
EnsemblBacteria AAC76071
BAE77091
GeneID 12934254
947521
KEGG ecj:Y75_p2961
eco:b3035
PATRIC 32121480
EchoBASE EB1002
EcoGene EG11009
eggNOG COG1538
HOGENOM HOG000283506
InParanoid P02930
KO K12340
OMA YNAKQQL
OrthoDB EOG6JHRGC
PhylomeDB P02930
BioCyc EcoCyc:EG11009-MONOMER
ECOL316407:JW5503-MONOMER
MetaCyc:EG11009-MONOMER
EvolutionaryTrace P02930
PRO PR:P02930
Proteomes UP000000318
UP000000625
Genevestigator P02930
GO GO:0009279
GO:0016021
GO:0015562
GO:0042802
GO:0015288
GO:0042930
GO:0015031
GO:0046677
GO:0014070
GO:0055085
InterPro IPR003423
IPR010130
PANTHER PTHR30026:SF3
Pfam PF02321
TIGRFAMs TIGR01844

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009279

cell outer membrane

PMID:10806384[1]

ECO:0000314

C

Table 1

complete

GO:0071320

cellular response to cAMP

PMID:21183666[2]

ECO:0000315

P

FIG. 1. IPTG concentration response curves for β-galactosidase induction in E. coli. The strains HfrC ({blacklozenge}) and the HfrC tolC ({blacksquare}) mutant were induced for 75 min, and the β-galactosidase activity was determined.

FIG. 3. cAMP concentration response curves for β-galactosidase induction in E. coli. Strains BTH2 cya ({blacklozenge}), H41 cya tolC ({blacksquare}), and H74 cya cpdA ({blacktriangleup}) were grown in LB medium to an OD600 of about 1.2, diluted 10-fold, and induced with 1 mM IPTG. After 75 min, the β-galactosidase activity was determined.


complete

enables

GO:0047485

protein N-terminus binding

PMID:15465872[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02978

F

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

PMID:15465872[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:15465872[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

PMID:15465872[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1990281

efflux pump complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11009
PANTHER:PTN002011530
UniProtKB:Q8ZLZ4

C

Seeded From UniProt

complete

enables

GO:0015562

efflux transmembrane transporter activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11009
PANTHER:PTN002011530
UniProtKB:Q8ZLZ4

F

Seeded From UniProt

complete

enables

GO:0015288

porin activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11009
PANTHER:PTN002011530

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25218435[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02930

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21245342[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02930

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16079137[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02930

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:10879525[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02930

F

Seeded From UniProt

complete

involved_in

GO:0042930

enterobactin transport

PMID:16166532[9]

ECO:0000316

genetic interaction evidence used in manual assertion

EcoliWiki:fur

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

PMID:9473050[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

PMID:6337123[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1990281

efflux pump complex

PMID:15155734[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P0AE06
UniProtKB:P31224

C

Seeded From UniProt

complete

part_of

GO:1990196

MacAB-TolC complex

PMID:28504659[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046618

drug export

PMID:11544226[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046618

drug export

PMID:28504659[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0015562

efflux transmembrane transporter activity

PMID:2112747[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0015288

porin activity

PMID:7688606[16]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

PMID:22534293[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

PMID:17309111[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

PMID:15911532[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

PMID:10806384[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0015562

efflux transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003423
InterPro:IPR010130

F

Seeded From UniProt

complete

part_of

GO:0019867

outer membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010130

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003423
InterPro:IPR010130

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0046

P

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0998
UniProtKB-SubCell:SL-0040

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Molloy, MP et al. (2000) Proteomic analysis of the Escherichia coli outer membrane. Eur. J. Biochem. 267 2871-81 PubMed GONUTS page
  2. ↑ Hantke, K et al. (2011) Escherichia coli exports cyclic AMP via TolC. J. Bacteriol. 193 1086-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Zakharov, SD et al. (2004) Colicin occlusion of OmpF and TolC channels: outer membrane translocons for colicin import. Biophys. J. 87 3901-11 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Agarwal, R et al. (2014) Structure-function of cyanobacterial outer-membrane protein, Slr1270: homolog of Escherichia coli drug export/colicin import protein, TolC. FEBS Lett. 588 3793-801 PubMed GONUTS page
  6. ↑ Pei, XY et al. (2011) Structures of sequential open states in a symmetrical opening transition of the TolC exit duct. Proc. Natl. Acad. Sci. U.S.A. 108 2112-7 PubMed GONUTS page
  7. ↑ Stenberg, F et al. (2005) Protein complexes of the Escherichia coli cell envelope. J. Biol. Chem. 280 34409-19 PubMed GONUTS page
  8. ↑ Koronakis, V et al. (2000) Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature 405 914-9 PubMed GONUTS page
  9. ↑ Bleuel, C et al. (2005) TolC is involved in enterobactin efflux across the outer membrane of Escherichia coli. J. Bacteriol. 187 6701-7 PubMed GONUTS page
  10. ↑ Aono, R et al. (1998) Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12. J. Bacteriol. 180 938-44 PubMed GONUTS page
  11. ↑ Morona, R et al. (1983) Identification and characterization of the TolC protein, an outer membrane protein from Escherichia coli. J. Bacteriol. 153 693-9 PubMed GONUTS page
  12. ↑ Tikhonova, EB & Zgurskaya, HI (2004) AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex. J. Biol. Chem. 279 32116-24 PubMed GONUTS page
  13. ↑ 13.0 13.1 Fitzpatrick, AWP et al. (2017) Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. Nat Microbiol 2 17070 PubMed GONUTS page
  14. ↑ Kobayashi, N et al. (2001) Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. J. Bacteriol. 183 5639-44 PubMed GONUTS page
  15. ↑ Wandersman, C & Delepelaire, P (1990) TolC, an Escherichia coli outer membrane protein required for hemolysin secretion. Proc. Natl. Acad. Sci. U.S.A. 87 4776-80 PubMed GONUTS page
  16. ↑ Benz, R et al. (1993) TolC of Escherichia coli functions as an outer membrane channel. Zentralbl. Bakteriol. 278 187-96 PubMed GONUTS page
  17. ↑ Han, MJ et al. (2012) Comparative analysis of envelope proteomes in Escherichia coli B and K-12 strains. J. Microbiol. Biotechnol. 22 470-8 PubMed GONUTS page
  18. ↑ Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page
  19. ↑ Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page
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