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ECOLI:MMUM

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) mmuM (synonyms: yagD)
Protein Name(s) Homocysteine S-methyltransferase

S-methylmethionine:homocysteine methyltransferase

External Links
UniProt Q47690
EMBL U70214
U00096
AP009048
PIR E64751
RefSeq NP_414795.1
YP_001816637.1
YP_488556.1
ProteinModelPortal Q47690
SMR Q47690
IntAct Q47690
STRING 511145.b0261
EnsemblBacteria AAC73364
BAA77929
GeneID 12930783
6275998
946143
KEGG ecj:Y75_p0252
eco:b0261
PATRIC 32115641
EcoGene EG13343
eggNOG COG2040
HOGENOM HOG000265278
InParanoid Q47690
KO K00547
OMA ACETIPC
OrthoDB EOG6C019S
PhylomeDB Q47690
BioCyc EcoCyc:MMUM-MONOMER
ECOL316407:JW0253-MONOMER
MetaCyc:MMUM-MONOMER
PRO PR:Q47690
Proteomes UP000000318
UP000000625
Genevestigator Q47690
GO GO:0046872
GO:0008898
GO:0006974
GO:0009086
GO:0033477
Gene3D 3.20.20.330
InterPro IPR003726
Pfam PF02574
SUPFAM SSF82282
PROSITE PS50970

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0033528

S-methylmethionine cycle

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001843930
UniProtKB:Q9M1W4

P

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001843930
UniProtKB:Q9M1W4
UniProtKB:Q9SDL7

P

Seeded From UniProt

complete

enables

GO:0008898

S-adenosylmethionine-homocysteine S-methyltransferase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13343
PANTHER:PTN001843930
UniProtKB:Q9M1W4
UniProtKB:Q9SDL7

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:11967071[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033477

S-methylmethionine metabolic process

PMID:9882684[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008898

S-adenosylmethionine-homocysteine S-methyltransferase activity

PMID:10026151[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:26564203[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017226

F

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017226

P

Seeded From UniProt

complete

enables

GO:0047150

betaine-homocysteine S-methyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017226

F

Seeded From UniProt

complete

involved_in

GO:0008652

cellular amino acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0028

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0486

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed GONUTS page
  3. Thanbichler, M et al. (1999) S-methylmethionine metabolism in Escherichia coli. J. Bacteriol. 181 662-5 PubMed GONUTS page
  4. Neuhierl, B et al. (1999) A family of S-methylmethionine-dependent thiol/selenol methyltransferases. Role in selenium tolerance and evolutionary relation. J. Biol. Chem. 274 5407-14 PubMed GONUTS page
  5. Li, K et al. (2016) Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli. Biochem. J. 473 277-84 PubMed GONUTS page