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ECOLI:MAO2

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) maeB (synonyms: ypfF)
Protein Name(s) NADP-dependent malic enzyme

NADP-ME

External Links
UniProt P76558
EMBL U00096
AP009048
PIR F65021
RefSeq NP_416958.1
YP_490690.1
ProteinModelPortal P76558
SMR P76558
DIP DIP-10141N
IntAct P76558
STRING 511145.b2463
BindingDB P76558
ChEMBL CHEMBL1687685
PaxDb P76558
PRIDE P76558
EnsemblBacteria AAC75516
BAA16337
GeneID 12931931
946947
KEGG ecj:Y75_p2415
eco:b2463
PATRIC 32120309
EchoBASE EB3945
EcoGene EG14193
eggNOG COG0281
HOGENOM HOG000132448
InParanoid P76558
KO K00029
OMA HRIERFG
OrthoDB EOG6QCD9W
PhylomeDB P76558
BioCyc EcoCyc:MALIC-NADP-MONOMER
ECOL316407:JW2447-MONOMER
MetaCyc:MALIC-NADP-MONOMER
PRO PR:P76558
Proteomes UP000000318
UP000000625
Genevestigator P76558
GO GO:0005829
GO:0004471
GO:0004473
GO:0030145
GO:0051287
GO:0008948
GO:0016746
GO:0006108
Gene3D 3.40.50.10380
3.40.50.720
InterPro IPR015884
IPR012301
IPR012302
IPR012188
IPR016040
IPR002505
Pfam PF00390
PF03949
PF01515
PIRSF PIRSF036684
SMART SM00919
PROSITE PS00331

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005829

cytosol

PMID:16858726[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

PMID:4385340[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

PMID:11092847[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

PMID:17557829[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012188

F

Seeded From UniProt

complete

enables

GO:0004471

malate dehydrogenase (decarboxylating) (NAD+) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012301
InterPro:IPR015884
InterPro:IPR037062

F

Seeded From UniProt

complete

involved_in

GO:0006108

malate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012188

P

Seeded From UniProt

complete

enables

GO:0016746

transferase activity, transferring acyl groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002505

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012188

F

Seeded From UniProt

complete

enables

GO:0051287

NAD binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012302

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012301
InterPro:IPR015884
InterPro:IPR037062

P

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.40

F

Seeded From UniProt

complete

enables

GO:0008948

oxaloacetate decarboxylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.40

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed GONUTS page
  2. Sanwal, BD et al. (1968) Allosteric control of the activity of malic enzyme in Escherichia coli. Biochem. Biophys. Res. Commun. 31 623-7 PubMed GONUTS page
  3. van der Rest, ME et al. (2000) Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Escherichia coli. J. Bacteriol. 182 6892-9 PubMed GONUTS page
  4. Bologna, FP et al. (2007) Escherichia coli malic enzymes: two isoforms with substantial differences in kinetic properties, metabolic regulation, and structure. J. Bacteriol. 189 5937-46 PubMed GONUTS page