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ECOLI:LEXA
Contents
Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
Gene Name(s) | lexA (ECO:0000255 with HAMAP-Rule:MF_00015) (synonyms: exrA, spr, tsl, umuA) | |
Protein Name(s) | LexA repressor (ECO:0000255 with HAMAP-Rule:MF_00015) | |
External Links | ||
UniProt | P0A7C2 | |
EMBL | J01643 U00006 U00096 AP009048 L02362 | |
PIR | A90808 | |
RefSeq | NP_418467.1 YP_492186.1 | |
PDB | 1JHC 1JHE 1JHF 1JHH 1LEA 1LEB 1MVD 1QAA 3JSO 3JSP 3K3R | |
PDBsum | 1JHC 1JHE 1JHF 1JHH 1LEA 1LEB 1MVD 1QAA 3JSO 3JSP 3K3R | |
ProteinModelPortal | P0A7C2 | |
SMR | P0A7C2 | |
DIP | DIP-51082N | |
IntAct | P0A7C2 | |
MINT | MINT-1314348 | |
STRING | 511145.b4043 | |
MEROPS | S24.001 | |
PaxDb | P0A7C2 | |
PRIDE | P0A7C2 | |
EnsemblBacteria | AAC77013 BAE78045 | |
GeneID | 12932724 948544 | |
KEGG | ecj:Y75_p3930 eco:b4043 | |
PATRIC | 32123623 | |
EchoBASE | EB0528 | |
EcoGene | EG10533 | |
eggNOG | COG1974 | |
HOGENOM | HOG000232167 | |
InParanoid | P0A7C2 | |
KO | K01356 | |
OMA | IAETGMP | |
OrthoDB | EOG6JHRHJ | |
PhylomeDB | P0A7C2 | |
BioCyc | EcoCyc:PD00205 ECOL316407:JW4003-MONOMER | |
EvolutionaryTrace | P0A7C2 | |
PRO | PR:P0A7C2 | |
Proteomes | UP000000318 UP000000625 | |
Genevestigator | P0A7C2 | |
GO | GO:0003677 GO:0004252 GO:0006974 GO:0006281 GO:0006260 GO:0045892 GO:0009432 GO:0006351 | |
Gene3D | 1.10.10.10 2.10.109.10 | |
HAMAP | MF_00015 | |
InterPro | IPR006200 IPR006199 IPR028360 IPR006197 IPR019759 IPR015927 IPR011991 | |
Pfam | PF01726 PF00717 | |
PRINTS | PR00726 | |
SUPFAM | SSF51306 | |
TIGRFAMs | TIGR00498 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0016481 |
negative regulation of transcription |
ECO:0000315 |
1 |
Figure 2 and Figure 3 |
complete | |||||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0005653 |
northern assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Contributes to |
GO:0009432 |
SOS response |
ECO:0000314 |
P |
Figure 3:RecA extended interface patch residues are involved in RecA active filament formation. The bacterial recombinase protein RecA is pivotal to DNA repair [1]–[4] and to orchestrate the bacterial DNA damage response (SOS response) against natural, or drug-induced, genotoxic conditions. |
complete | ||||
Contributes to |
GO:0009432 |
ECO:0000315 |
Figure 3:RecA extended interface patch residues are involved in RecA active filament formation. The bacterial recombinase protein RecA is pivotal to DNA repair [1]–[4] and to orchestrate the bacterial DNA damage response (SOS response) against natural, or drug-induced, genotoxic conditions. |
complete | ||||||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0001808 |
reverse transcription polymerase chain reaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0001808 |
reverse transcription polymerase chain reaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0005643 |
hydroxyl-radical footprinting evidence used in manual assertion |
RefSeq:NC_000913.2 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0001217 |
DNA-binding transcription repressor activity |
ECO:0005643 |
hydroxyl-radical footprinting evidence used in manual assertion |
RefSeq:NC_000913.2 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0001217 |
DNA-binding transcription repressor activity |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0001217 |
DNA-binding transcription repressor activity |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0001217 |
DNA-binding transcription repressor activity |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0005643 |
hydroxyl-radical footprinting evidence used in manual assertion |
RefSeq:NC_000913.2 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009432 |
SOS response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009432 |
SOS response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006351 |
transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006351 |
transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006351 |
transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009432 |
SOS response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006260 |
DNA replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000075652 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000075652 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000075652 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009432 |
SOS response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000075652 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000075652 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000075652 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000075652 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006260 |
DNA replication |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009432 |
SOS response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Pacelli, LZ et al. (1979) Isolation and characterization of amber mutations in the lexA gene of Escherichia coli K-12. J. Bacteriol. 137 568-73 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Fernández De Henestrosa, AR et al. (2000) Identification of additional genes belonging to the LexA regulon in Escherichia coli. Mol. Microbiol. 35 1560-72 PubMed GONUTS page
- ↑ 3.0 3.1 Adikesavan, AK et al. (2011) Separation of recombination and SOS response in Escherichia coli RecA suggests LexA interaction sites. PLoS Genet. 7 e1002244 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Cambray, G et al. (2011) Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons. Mob DNA 2 6 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Prysak, MH et al. (2009) Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage. Mol. Microbiol. 71 1071-87 PubMed GONUTS page
- ↑ Rajagopala, SV et al. (2014) The binary protein-protein interaction landscape of Escherichia coli. Nat. Biotechnol. 32 285-90 PubMed GONUTS page
- ↑ Zhang, AP et al. (2010) Structure of the LexA-DNA complex and implications for SOS box measurement. Nature 466 883-6 PubMed GONUTS page
- ↑ Mount, DW et al. (1972) Dominant mutations (lex) in Escherichia coli K-12 which affect radiation sensitivity and frequency of ultraviolet lght-induced mutations. J. Bacteriol. 112 886-93 PubMed GONUTS page
- ↑ Lin, LL & Little, JW (1988) Isolation and characterization of noncleavable (Ind-) mutants of the LexA repressor of Escherichia coli K-12. J. Bacteriol. 170 2163-73 PubMed GONUTS page
- ↑ McCall, JO et al. (1987) Constitutive expression of the SOS response in recA718 mutants of Escherichia coli requires amplification of RecA718 protein. J. Bacteriol. 169 728-34 PubMed GONUTS page
- ↑ Little, JW & Harper, JE (1979) Identification of the lexA gene product of Escherichia coli K-12. Proc. Natl. Acad. Sci. U.S.A. 76 6147-51 PubMed GONUTS page
- ↑ Brent, R & Ptashne, M (1981) Mechanism of action of the lexA gene product. Proc. Natl. Acad. Sci. U.S.A. 78 4204-8 PubMed GONUTS page
- ↑ Little, JW et al. (1981) Purified lexA protein is a repressor of the recA and lexA genes. Proc. Natl. Acad. Sci. U.S.A. 78 4199-203 PubMed GONUTS page
- ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
- ↑ Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page
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