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ECOLI:ISCA

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) iscA (synonyms: yfhF)
Protein Name(s) Iron-binding protein IscA

Iron-sulfur cluster assembly protein

External Links
UniProt P0AAC8
EMBL U01827
U00096
AP009048
PIR G65029
RefSeq NP_417023.1
YP_490756.1
PDB 1R94
1R95
1S98
PDBsum 1R94
1R95
1S98
ProteinModelPortal P0AAC8
SMR P0AAC8
DIP DIP-35854N
IntAct P0AAC8
STRING 511145.b2528
PaxDb P0AAC8
PRIDE P0AAC8
EnsemblBacteria AAC75581
BAA16422
GeneID 12931609
946999
KEGG ecj:Y75_p2481
eco:b2528
PATRIC 32120453
EchoBASE EB2053
EcoGene EG12132
eggNOG COG0316
HOGENOM HOG000228314
InParanoid P0AAC8
KO K13628
OMA YDGFKIV
OrthoDB EOG6VXF8J
PhylomeDB P0AAC8
BioCyc EcoCyc:EG12132-MONOMER
ECOL316407:JW2512-MONOMER
MetaCyc:EG12132-MONOMER
EvolutionaryTrace P0AAC8
PRO PR:P0AAC8
Proteomes UP000000318
UP000000625
Genevestigator P0AAC8
GO GO:0051537
GO:0008198
GO:0034986
GO:0005198
GO:0016226
Gene3D 2.60.300.12
HAMAP MF_01429
InterPro IPR000361
IPR016092
IPR017870
IPR011302
Pfam PF01521
SUPFAM SSF89360
TIGRFAMs TIGR02011
TIGR00049
PROSITE PS01152

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0051537

2 iron, 2 sulfur cluster binding

PMID:11319236[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016226

iron-sulfur cluster assembly

PMID:11319236[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097428

protein maturation by iron-sulfur cluster transfer

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001601055
PomBase:SPCC645.03c
SGD:S000003950

P

Seeded From UniProt

complete

enables

GO:0051537

2 iron, 2 sulfur cluster binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11378
EcoGene:EG12132
PANTHER:PTN001601055
PomBase:SPCC645.03c
UniProtKB:P72731
UniProtKB:P74596

F

Seeded From UniProt

complete

involved_in

GO:0016226

iron-sulfur cluster assembly

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11378
EcoGene:EG12132
PANTHER:PTN001601055
SGD:S000003950
UniProtKB:P74596

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12132
PANTHER:PTN000008063

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12132
PANTHER:PTN000008061

C

Seeded From UniProt

complete

enables

GO:0034986

iron chaperone activity

PMID:15247288[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0034986

iron chaperone activity

PMID:14720122[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016226

iron-sulfur cluster assembly

PMID:10544286[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008198

ferrous iron binding

PMID:14720122[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15911532[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016092

F

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011302

F

Seeded From UniProt

complete

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011302
InterPro:IPR016092

F

Seeded From UniProt

complete

involved_in

GO:0097428

protein maturation by iron-sulfur cluster transfer

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011302
InterPro:IPR016092

P

Seeded From UniProt

complete

involved_in

GO:0016226

iron-sulfur cluster assembly

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000076508

P

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000076508

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Ollagnier-de-Choudens, S et al. (2001) Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin. J. Biol. Chem. 276 22604-7 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Ding, H et al. (2004) IscA mediates iron delivery for assembly of iron-sulfur clusters in IscU under the limited accessible free iron conditions. J. Biol. Chem. 279 37499-504 PubMed GONUTS page
  4. ↑ 4.0 4.1 Ding, H & Clark, RJ (2004) Characterization of iron binding in IscA, an ancient iron-sulphur cluster assembly protein. Biochem. J. 379 433-40 PubMed GONUTS page
  5. ↑ Takahashi, Y & Nakamura, M (1999) Functional assignment of the ORF2-iscS-iscU-iscA-hscB-hscA-fdx-ORF3 gene cluster involved in the assembly of Fe-S clusters in Escherichia coli. J. Biochem. 126 917-26 PubMed GONUTS page
  6. ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  7. ↑ Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page
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